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The Role of Antiepileptic Drugs

  • Mahinda Yogarajah
  • Marco MulaEmail author
Part of the Neuropsychiatric Symptoms of Neurological Disease book series (NSND)

Abstract

Antiepileptic drugs (AEDs) suppress seizures by acting on a variety of mechanisms and molecular targets involved in the regulation of neuronal excitability. These include inhibitory (GABAergic) and excitatory (glutamatergic) neurotransmission, as well as ion (sodium and calcium) conductance through voltage-gated channels. However, these mechanisms and targets are also implicated in the regulation of mood and behavior, which may explain why each AED is associated with specific psychotropic effects. This chapter will discuss the role of mechanisms and molecular targets of AEDs in mood and behavior, and review the positive and negative psychotropic effects of AEDs.

Keywords

Epilepsy Antiepileptic drugs Depression Psychosis Anxiety Anticonvulsant Mania Behavior 

Abbreviations

AED

Antiepileptic drug

CBZ

Carbamazepine

EMA

European Medicines Agency

ESL

Eslicarbazepine

ETX

Ethosuximide

FDA

Food and Drug Administration

FLB

Felbamate

GBP

Gabapentin

HRSA

Hamilton Rating Scale for Anxiety

LAC

Lacosamide

LEV

Levetiracetam

LTG

Lamotrigine

OXC

Oxcarbazepine

PGB

Pregabalin

PHT

Phenytoin

RTG

Retigabine

RUF

Rufinamide

STP

Stiripentol

TGB

Tiagabine

TPM

Topiramate

VGB

Vigabatrin

VPA

Valproate

ZNS

Zonisamide

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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Epilepsy GroupAtkinson Morley Regional Neuroscience Centre, St. George’s University Hospitals NHS Foundation TrustLondonUK
  2. 2.Institute of Medical and Biomedical SciencesSt George’s University of LondonLondonUK

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