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Abstract

Cancer is the major cause of pediatric mortality and morbidity. It is the second most common cause of death in children less than 15 years of age [1, 2]. Although the 5-year survival rates exceed 80 %, this leaves chronic and debilitating sequelae for many of these children [3, 4]. The incidence and types of cancer differ with age and differ dramatically from adults (Table 16.1). The pediatric anesthesiologist must be prepared to manage the various conditions associated with cancer patients, as well as the consequences of cancer therapy modalities. Children with cancer can have serious multisystem disease and are prone to various toxicities from chemotherapy and/or radiation therapy and the associated pharmacological treatment.

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  1. 1.

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References

  1. Jemal A, Siegal R, Ward E et al (2009) Cancer statistics, 2009. CA Cancer J Clin 59(4):225–249

    Article  PubMed  Google Scholar 

  2. Ries LA, Percy CL, Bunin GR (1999) Introduction. In: Ries LA, Smith MA, Gurney JG et al (eds) Cancer incidence and survival among children and adolescents: Unites States SEER Program 1975–1995. National Cancer Institute SEER Program, Bethesda, p 1. NIH Pub. No. 99–4649 ed

    Google Scholar 

  3. Horner MJ, Ries LA, Krapcho M (2009) SEER cancer statistics review, 1975–2006. National Cancer Institute, Bethesda

    Google Scholar 

  4. Oeffinger KC, Mertens AC, Sklar CA et al (2006) Chronic health conditions in adult survivors of childhood cancer. N Engl J Med 355(15):1572–1582

    Article  CAS  PubMed  Google Scholar 

  5. Heaney A, Buggy DJ (2012) Can anesthetic and analgesic techniques affect cancer recurrence or metastasis? Br J Anaesth 109(Supp 1):i17–i28

    Article  PubMed  Google Scholar 

  6. Tavare AN, Perry NJ, Benzonana LL et al (2012) Cancer recurrence after surgery: direct and indirect effects of anesthetic agents. Int J Cancer 130(6):1237–1250

    Article  CAS  PubMed  Google Scholar 

  7. Burrows FA, Hickey PR, Colan S (1985) Perioperative complications in patients with anthracycline chemotherapeutic agents. Can Anaesth Soc J 32:149–157, PubMed: 3986652

    Article  CAS  PubMed  Google Scholar 

  8. Lahtinen R, Kuikka J, Nousianinen T et al (1991) Cardiotoxicity of epirubicin and doxorubicin: a double-blind randomized study. Eur J Haematol 46:301–305, PubMed:2044726

    Article  CAS  PubMed  Google Scholar 

  9. Lekakis J, Vassilopoulos N, Psichoyiou H et al (1991) Doxorubicin cardiotoxicity detected by indium 111 myosin-specific imaging. Eur J Nucl Med 18:225–226, PubMed: 1645666

    Article  CAS  PubMed  Google Scholar 

  10. Weesner KM, Bledsoe M, Chauvenet A et al (1991) Exercise echocardiography in the detection of anthracycline cardiotoxicity. Cancer 68:435–438, PubMed: 2070339

    Article  CAS  PubMed  Google Scholar 

  11. Huettemann E, Junker T, Chatzinikolaou KP et al (2004) The influence of anthracycline therapy on cardiac function during anesthesia. Anesth Analg 98:941–947, PubMed: 15041577

    Article  PubMed  Google Scholar 

  12. Steinherz LJ, Steinherz PG, Tan CT et al (1991) Cardiac toxicity 4 to 20 years after completing anthracycline therapy. JAMA 266:1672–1677, PubMed: 1886191

    Article  CAS  PubMed  Google Scholar 

  13. Steinberg JS, Cohen AJ, Wasserman AG, Cohen P, Ross AM (1987) Acute arrhythmogenicity of doxorubicin administration. Cancer 60:1213–1218, PubMed: 3621107

    Article  CAS  PubMed  Google Scholar 

  14. Bristow MR, Billingham ME, Mason JW, Daniels JR (1978) Clinical spectrum of anthracycline antibiotic cardiotoxicity. Cancer Treat Rep 62:873–879, PubMed: 667861

    CAS  PubMed  Google Scholar 

  15. Praga C, Beretta G, Vigo PL, Pollini C, Bonadonna G, Canetta R et al (1979) Adriamycin cardiotoxicity: a survey of 1273 patients. Cancer Treat Rep 63:827–834, PubMed: 455324

    CAS  PubMed  Google Scholar 

  16. Von Hoff DD, Layward MW, Basa P, Davis HL Jr, Von Hoff AL, Rozencweig M et al (1979) Risk factors for doxorubicin–induced congestive heart failure. Ann Intern Med 91:710–717, PubMed: 496103

    Article  Google Scholar 

  17. Shan K, Lincoff AM, Young JB (1996) Anthracycline-induced cardiotoxicity. Ann Intern Med 125:47–58, PubMed: 8644988

    Article  CAS  PubMed  Google Scholar 

  18. Solley GO, Maldonado JE, Gleich GJ et al (1976) Endomyocardiopathy with eosinophilia. Mayo Clin Proc 51:697–708, PubMed: 994551

    CAS  PubMed  Google Scholar 

  19. Drzewoski J, Kasznicki J (1992) Cardiotoxicity of antineoplastic drugs. Acta Haematol Pol 23:79–86, PubMed: 1488864

    CAS  PubMed  Google Scholar 

  20. Verweij J (1996) Mitomycins. Cancer Chemother Biol Response Modif 6:46–58, PubMed: 8639396

    Google Scholar 

  21. Cortes JE, Pazdur R (1995) Docetaxel. J Clin Oncol 13:2643–2655, PubMed: 7595719

    CAS  PubMed  Google Scholar 

  22. Gehdoo RP (2009) Anticancer chemotherapy and it’s anaesthetic implications (current concepts). Indian J Anaesth 53(1):18–29. PMCID: PMC2900029

    PubMed Central  CAS  PubMed  Google Scholar 

  23. Varon J (1995) Acute respiratory distress syndrome in the postoperative cancer patient. Cancer Bull 47:38–42

    Google Scholar 

  24. Dumont P, Wihim JM, Hentz JG et al (1995) Respiratory complications after surgical treatment of esophageal cancer: a study of 309 patients according to the type of resection. Eur J Cardiothorac Surg 9:539–543, PubMed: 8562096

    Google Scholar 

  25. Epner DE, White F, Krasnoff M et al (1996) Outcome of mechanical ventilation for adults with hematologic malignancy. J Invest Med 44:254–260

    Google Scholar 

  26. Randle CJ Jr, Frankel LR, Amylon MD (1996) Identifying early predictors of mortality in pediatric patients with acute leukemia and pneumonia. Chest 109:457–461, PubMed: 8620722

    Article  PubMed  Google Scholar 

  27. Waid-Jones M, Coursin DB (1991) Perioperative considerations for patients treated with bleomycin. Chest 99:993–999, PubMed: 1706974

    Article  CAS  PubMed  Google Scholar 

  28. Goldiner PL, Schweizer O (1979) The hazards of anesthesia and surgery in Bleomycin-treated patients. Semin Oncol 6:121–124, PubMed: 88070

    CAS  PubMed  Google Scholar 

  29. Goldiner PL, Carlon GC, Cvitkovic E, Schweizer O, Howland W (1978) Factors influencing postoperative morbidity and mortality in patients treated with bleomycin. Br Med J 1:1664–1667. PMCID: PMC1605498

    Google Scholar 

  30. LaMantia KR, Glick JH, Marshall BE (1984) Supplemental oxygen does not cause respiratory failure in Bleomycin-treated surgical patients. Anesthesiology 60:65–67, PubMed: 6197912

    Article  CAS  PubMed  Google Scholar 

  31. Donat SM, Levy DA (1998) Bleomycin associated pulmonary toxicity: is perioperative oxygen restriction necessary? J Urol 160:1347–1352, PubMed: 9751352

    Article  CAS  PubMed  Google Scholar 

  32. Madias NE, Harrington JT (1978) Platinum nephrotoxicity. Am J Med 65:307–314, PubMed: 99034

    Google Scholar 

  33. Fjeldberg P, Sorensen J, Helkjaer PE (1986) The long term effects of cisplatin on renal function. Cancer 58:2214–2217, PubMed: 3756770

    Article  Google Scholar 

  34. Frenia ML, Long KS (1992) Methotrexate and nonsteroidal antiinflammatory drug interactions. Ann Pharmacother 26:234–237, PubMed: 1554938

    Google Scholar 

  35. Huettemann E, Sakka SG (2005) Anaesthesia and anti-cancer chemotherapeutic drugs. Curr Opin Anaesthesiol 18:307–314

    Google Scholar 

  36. Reddy GK, Brown B, Nanda A (2011) Fatal consequences of a simple mistake: how can a patient be saved from inadvertent intrathecal vincristine? Clin Neurol Neurosurg 113:68–71

    Article  PubMed  Google Scholar 

  37. Latham GJ (2014) Anesthesia for the child with cancer. Anesthesiol Clin 32:185–213

    Article  PubMed  Google Scholar 

  38. Treleaven J, Gennery A, Marsh J et al (2011) Guidelines on the use of irradiated blood components prepared by the British Committee for Standards in Haematology blood transfusion task force. Br J Haematol 152:35–51

    Article  PubMed  Google Scholar 

  39. Schaffer MR, Barbul A (1996) Chemotherapy and wound healing. In: Lefor AT (ed) Surgical problems affecting the patient with cancer. Lippincott-Raven, Philadelphia, pp 305–320

    Google Scholar 

  40. Axelrod L. Perioperative management of patients treated with glucocorticoids (2003) Endocrinol Metabol Clin North Am 32:367–383

    Google Scholar 

  41. Sabourdin N (2015) Steroids: the evidence. The rationale for perioperative glucocorticoid supplementation for patients under chronic steroid treatment. Curr Anesthesiol Rep 5(2):140–146

    Article  Google Scholar 

  42. Garcia JEL, Hill GE, Joshi GP (2013) Perioperative stress dose steroids: is it really necessary? Am Soc Anesthesiol Newsletter 77(11)

    Google Scholar 

  43. Marik PE, Varon J (2008) Requirement of perioperative stress doses of corticosteroids: a systematic review of the literature. Arch Surg 143:1222–1226

    Article  CAS  PubMed  Google Scholar 

  44. Anderson RJ, Chung HM, Kluge R et al (1985) Hyponatremia: a prospective analysis of its epidemiology and the pathogenetic role of vasopressin. Ann Intern Med 102:164–168, PubMed: 3966753

    Article  CAS  PubMed  Google Scholar 

  45. Zsigmond EK, Robins G (1972) The effect of a series of anticancer drugs on plasma cholinesterase activity. Can Anaesth Soc J 19:75–82, PubMed: 4257896

    Article  CAS  PubMed  Google Scholar 

  46. Latham GJ, Greenberg RS (2010) Anesthetic considerations for the pediatric oncology patient – part 2: systems-based approach to anesthesia. Pediatr Anesth 20:396–420

    Article  Google Scholar 

  47. Landier W, Armenian S, Bhatia S (2015) Late effects of childhood cancer and its treatment. Pediatr Clin North Am 62:275–300

    Article  PubMed  Google Scholar 

  48. Adams MJ, Lipshultz SE, Schwartz C et al (2003) Radiation associated cardiovascular disease: manifestations and management. Semin Radiat Oncol 13(3):346–356

    Article  PubMed  Google Scholar 

  49. Lerman J (2007) Anterior mediastinal masses in children. Semin Anesth Perioper Med Pain 26:133–140

    Article  Google Scholar 

  50. Borenstein SH, Gerstle T, Malkin D et al (2000) The effects of pre-biopsy corticosteroid treatment on the diagnosis of mediastinal lymphoma. J Pediatr Surg 35:973–976

    Article  CAS  PubMed  Google Scholar 

  51. McDonnell C, Barlow R, Campisi P et al (2008) Fatal peri-operative acute tumour lysis syndrome precipitated by dexamethasone. Anaesthesia 63:652–655

    Article  CAS  PubMed  Google Scholar 

  52. Berry GJ, Jorden M (2005) Pathology of radiation and anthracycline cardiotoxicity. Pediatr Blood Cancer 44(7):630–637

    Article  PubMed  Google Scholar 

  53. Latham GJ, Greenberg RS (2010) Anesthetic considerations for the pediatric oncology patient – part 3: pain, cognitive dysfunction, and preoperative evaluation. Pediatr Anaesth 20(6):479–489

    Google Scholar 

  54. Abid SH, Malhotra V, Perry MC (2001) Radiation-induced and chemotherapy-induced pulmonary injury. Curr Opin Oncol 13(4):242–248

    Article  CAS  PubMed  Google Scholar 

  55. Faroux B, Meyer-Milsztain A, Boccon-Gibod L et al (1994) Cytotoxic drug-induced pulmonary disease in infants and children. Pediatr Pulmonol 18(6):347–355

    Article  Google Scholar 

  56. Cerveri I, Fulgoni P, Giorgiani G et al (2001) Lung function abnormalities after bone marrow transplantation in children: has the trend recently changed? Chest 120(6):1900–1906

    Article  CAS  PubMed  Google Scholar 

  57. Marras TK, Szalai JP, Chan CK et al (2002) Pulmonary function abnormalities after allogenic marrow transplantation: a systemic review and assessment of an existing predictive instrument. Bone Marrow Transplant 30(9):599–607

    Article  CAS  PubMed  Google Scholar 

  58. Litten JB, Tomlinson GE (2008) Liver tumors in children. Oncologist 13(7):812–820

    Article  PubMed  Google Scholar 

  59. Hata M, Ogino I, Aida N et al (2001) Prophylactic cranial irradiation of acute lymphoblastic leukemia in childhood: outcomes of late effects on pituitary function and growth in long-term survivors. Int J Cancer 96(Suppl):117–124

    Article  CAS  PubMed  Google Scholar 

  60. Madanat LM, Lahteenmaki PM, Hurme S et al (2008) Hypothyroidism among pediatric cancer patients: a nationwide, registry based study. Int J Cancer 122(8):1868–1872

    Article  CAS  PubMed  Google Scholar 

  61. Golub TR, Arceci RJ (2006) Acute myelogenous leukemia. In: Pizzo PA, Poplack DG (eds) Principles and practice of pediatric oncology, 5th edn. Lippincott Williams & Wilkins, Philadelphia, p 591

    Google Scholar 

  62. Cairo MS, Bishop M (2004) Tumour lysis syndrome: new therapeutic strategies and classification. Br J Haematol 127:3–11, PubMed: 15384972

    Article  PubMed  Google Scholar 

  63. Shimada M, Johnson RJ, May WS Jr et al (2009) A novel role for uric acid in acute kidney injury associated with tumour lysis syndrome. Nephrol Dial Transplant 24:2960–2964, PubMed: 19581334

    Article  CAS  PubMed  Google Scholar 

  64. Nakamura M, Oda S, Sadahiro T et al (2009) The role of hypercytokinemia in the pathophysiology of tumor lysis syndrome (TLS) and the treatment with continuous hemodiafiltration using a polymethylmethacrylate membrane hemofilter (PMMA-CHDF). Transfus Apher Sci 40:41–47, PubMed: 19109071

    Article  PubMed  Google Scholar 

  65. Hechler T, Ruhe AK, Schmidt P et al (2013) Inpatient-based intensive interdisciplinary pain treatment for highly impaired children with severe chronic pain: randomized controlled trial of efficacy and economic effects. Pain (2014) 155:118–128

    Google Scholar 

  66. Zeppetella G, O’Doherty CA, Collins S (2000) Prevalence and characteristics of breakthrough pain in cancer patients admitted to a hospice. J Pain Symptom Manage 20:87–92

    Article  CAS  PubMed  Google Scholar 

  67. Friedrichsdorf S, Finney D, Bergin M, Stevens M, Collins J (2007) Breakthrough pain in children with cancer. J Pain Symptom Manage 34:209–216

    Article  PubMed  Google Scholar 

  68. Friedrichsdorf SJ, Postier A (2014) Management of breakthrough pain in children with cancer. J Pain Res 7:117–123

    Google Scholar 

  69. Drake R, Longworth J, Collins JJ (2004) Opioid rotation in children with cancer. J Palliat Med 7:419–422

    Article  PubMed  Google Scholar 

  70. Finkel JC, Finley A, Greco C, Weisman SJ, Zeltzer L (2005) Transdermal fentanyl in the management of children with chronic sever pain: results from an international study. Cancer 104:2847–2857

    Google Scholar 

  71. Finkel JC, Pestieau SR, Quezado ZM (2007) Ketamine as an adjuvant for treatment of cancer pain in children and adolescents. J Pain 8:515–521

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Jerrold Lerman MD, FRCPC, FANZCA .

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Virk, N., Senbruna, B., Lerman, J. (2016). Perioperative Care of Children with Cancer. In: Astuto, M., Ingelmo, P. (eds) Perioperative Medicine in Pediatric Anesthesia. Anesthesia, Intensive Care and Pain in Neonates and Children. Springer, Cham. https://doi.org/10.1007/978-3-319-21960-8_16

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