Bioengineered Human Heart and Skeletal Muscles on Chips: Methods and Applications

  • Ki-Hwan Nam
  • Mikael Perla
  • Alec S. T. Smith
  • Deok-Ho Kim
Part of the Biosystems & Biorobotics book series (BIOSYSROB, volume 9)


This chapter introduces innovative organ-on-chip platforms for chemical assay and toxicity testing that measures the physiological properties of live, engineered muscular tissue samples. The advantages of using such engineered tissues for drug screening compared to more conventional cell-based assays are discussed. Specifically, this chapter will outline recent developments and applications of cardiac and skeletal muscle organ-on-chip systems. Recent advances in micro- and nanofabrication techniques, along with their biological applications with regard to organ-on-chips, are also reviewed in this chapter.


Organ-on-chip Heart-on-chip Muscle-on-chip Micro/nanofabrication 


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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  • Ki-Hwan Nam
    • 2
  • Mikael Perla
    • 1
  • Alec S. T. Smith
    • 1
  • Deok-Ho Kim
    • 1
    • 3
    • 4
  1. 1.Department of BioengineeringUniversity of WashingtonSeattleUSA
  2. 2.Optical Instrumentation Development TeamThe Korea Basic Science InstituteDaejeonKorea
  3. 3.Institute for Stem Cell and Regenerative MedicineUniversity of WashingtonSeattleUSA
  4. 4.Center for Cardiovascular BiologyUniversity of WashingtonSeattleUSA

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