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Recent Advances in Regenerative Approaches to Intervertebral Disc Degeneration

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Biomedical Engineering: Frontier Research and Converging Technologies

Part of the book series: Biosystems & Biorobotics ((BIOSYSROB,volume 9))

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Abstract

Intervertebral disc (IVD) degeneration is one of the major neurodegenerative diseases throughout the world. Development of new and advanced treatment methods are highly warranted due to the limitations of conventional protocols. Very recently, regenerative medicine techniques based on biomaterials, stem cell and bioactive molecules have been demonstrated as the most powerful concept to regenerate IVD. In this chapter, we will review the recent progress in (1) biomaterial scaffolds for annulus fibrosus (AF), nucleus pulposus (NP) and cartilaginous end plates (CEP), (2) stem cells as cell sources, and finally introduce (3) our recent research studies focusing on the fabrication of natural/synthetic hybrid scaffolds for various purposes during the last 5 years.

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Authors and Affiliations

  1. Department of Polymer Nano Science & Technology, Department of BIN Fusion Technology, Chonbuk National University, Jeonju, 561-756, Republic of Korea

    Gilson Khang, Jeong Eun Song, Nirmalya Tripathy, Eun Young Kim & Dongwon Lee

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  1. Gilson Khang
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  2. Jeong Eun Song
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  3. Nirmalya Tripathy
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  4. Eun Young Kim
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Editors and Affiliations

  1. Coulter Department of Biomedical Engineering, Georgia Tech and Emory University, Atlanta, Georgia, USA

    Hanjoong Jo

  2. Department of Biomedical Engineering, The University of Alabama at Birmingham, Birmingham, AL, Alabama, USA

    Ho-Wook Jun

  3. Department of Mechanical Engineering Soft Biomechanics & Biomaterials Lab, Korea Advanced Institute of Science and Technology, Daejeon (KAIST), Korea (Republic of)

    Jennifer Shin

  4. Department of Biomedical Engineering, College of Health Science, Korea University, Seoul, Korea (Republic of)

    SangHoon Lee

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Khang, G., Song, J.E., Tripathy, N., Kim, E.Y., Lee, D. (2016). Recent Advances in Regenerative Approaches to Intervertebral Disc Degeneration. In: Jo, H., Jun, HW., Shin, J., Lee, S. (eds) Biomedical Engineering: Frontier Research and Converging Technologies. Biosystems & Biorobotics, vol 9. Springer, Cham. https://doi.org/10.1007/978-3-319-21813-7_18

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