Abstract
Among endometrial epithelial lesions, common nonneoplastic conditions (metaplasia, hormone-related changes, endometrial polyp, and gestational alterations) can mimic malignant or premalignant lesions of the endometrium. Endometrial carcinoma is the most common cancer of the female genital tract. Long-term estrogen overload through obesity, hormone replacement, oral contraceptives, and smoking is significantly associated with the most common subtype, endometrioid adenocarcinoma (type 1 endometrial cancer, 70–80 %) and its precursor lesion—atypical endometrial hyperplasia. A smaller subset of endometrial cancers (10–15 %) is represented by serous and clear cell carcinomas (type 2 endometrial cancer) that are high grade by definition and almost always occur in postmenopausal women. Mixed carcinoma is defined by the presence of two histological types of epithelial malignancy, one of which is type 2 (serous or clear cell carcinoma) and the minor component constitutes at least 5 % of the entire tumor. The current (2014) WHO classification of endometrial carcinomas is summarized in Table 4.1. Other histological subtypes of endometrial carcinoma are rare, including neuroendocrine tumors and undifferentiated/dedifferentiated carcinomas.
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Hui, P., Buza, N. (2015). Endometrial Epithelial Lesions. In: Atlas of Intraoperative Frozen Section Diagnosis in Gynecologic Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-21807-6_4
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DOI: https://doi.org/10.1007/978-3-319-21807-6_4
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