Abstract
During sleep, there is missing wakeful stimulus to spontaneous breathing and respiration is regulated mainly by CO2 homeostasis. Continuous positive airway pressure (CPAP) therapy is capable of treating obstructive events but does not provide ventilation during times of central apneas. Different forms of positive pressure ventilation are able to generate airflow in the absence of respiratory drive. To restore regular breathing, however, pressure support should primarily compensate apneic episodes without increasing ventilation during spontaneous breaths. Otherwise, the loop-feedback mechanism will not adjust back to CO2 hemostasis. Servo-ventilation provides pressure support disproportional to spontaneous breathing effort and, therefore, has the best potential to compensate central events.
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Dellweg, D., Wenzel, M., Kerl, J. (2016). Results of Servo-ventilation and Other Ventilatory Modes in Sleep Apnea Syndrome: Key Topics and Practical Implications. In: Esquinas, A. (eds) Noninvasive Mechanical Ventilation. Springer, Cham. https://doi.org/10.1007/978-3-319-21653-9_78
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DOI: https://doi.org/10.1007/978-3-319-21653-9_78
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