Skip to main content

Abstract

Craniopharyngiomas are rare epithelial tumors arising along the path of the craniopharyngeal duct, and as a consequence, they can be found from rhinopharynx to hypothalamus [6, 30, 31]. They develop in a deep-seated area of the brain, involving in many cases several vital structures, such as the hypothalamus, that are of paramount importance for vegetative, endocrine, and emotional functions as well as for maintaining body homeostasis. As a matter of fact, the functional impairment and anatomical distortion of the hypothalamus that may be caused by such kind of tumor have to be considered as critical factors influencing patient outcome.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 149.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Babinski J (1900) Tumeur du corps pituitaire sans acrome ́galie et avec arreˆt de de ́veloppement des organes genitaux. Revue neurologique, Paris

    Google Scholar 

  2. Backlund EO, Axelsson B, Bergstrand CG, Eriksson AL, Noren G, Ribbesjo E et al (1989) Treatment of craniopharyngiomas–the stereotactic approach in a ten to twenty-three years’ perspective. I. Surgical, radiological and ophthalmological aspects. Acta Neurochir (Wien) 99:11–19

    Article  CAS  Google Scholar 

  3. Boyce R, Beadles CF (1893) A further contribution to the study of the pathology of the hypophysis cerebri. J Pathol 1:359–383

    Article  Google Scholar 

  4. Bunin GR, Surawicz TS, Witman PA, Preston-Martin S, Davis F, Bruner JM (1998) The descriptive epidemiology of craniopharyngioma. J Neurosurg 89:547–551

    Article  CAS  PubMed  Google Scholar 

  5. Cappabianca P, Cavallo LM, Esposito F, De Divitiis E (2008) Craniopharyngiomas. J Neurosurg 109:1–3

    Article  PubMed  Google Scholar 

  6. Cappabianca P, Cavallo LM, Solari D, Di Somma A, Del Basso De Caro ML (2015) Introduction and outcome. In: Evans JJ, Kenning TJ (eds) Craniopharyngiomas: a comprehensive guide to diagnosis, treatment, and outcome. Elsevier, Amsterdam, pp 137–153

    Google Scholar 

  7. Cavallo LM, Frank G, Cappabianca P, Solari D, Mazzatenta D, Villa A et al (2014) The endoscopic endonasal approach for the management of craniopharyngiomas: a series of 103 patients. J Neurosurg 121(1):100–113

    Article  PubMed  Google Scholar 

  8. Cavallo LM, Prevedello DM, Solari D, Gardner PA, Esposito F, Snyderman CH et al (2009) Extended endoscopic endonasal transsphenoidal approach for residual or recurrent craniopharyngiomas. J Neurosurg 111:578–589

    Article  PubMed  Google Scholar 

  9. Ciric IS, Cozzens JW (1980) Craniopharyngiomas: transsphenoidal method of approach – for the virtuoso only? Clin Neurosurg 27:169–187

    CAS  PubMed  Google Scholar 

  10. Cohen M, Bartels U, Branson H, Kulkarni AV, Hamilton J (2013) Trends in treatment and outcomes of pediatric craniopharyngioma, 1975–2011. Neuro Oncol 15:767–774

    Article  PubMed Central  PubMed  Google Scholar 

  11. Crotty TB, Scheithauer BW, Young WF Jr, Davis DH, Shaw EG, Miller GM et al (1995) Papillary craniopharyngioma: a clinicopathological study of 48 cases. J Neurosurg 83:206–214

    Article  CAS  PubMed  Google Scholar 

  12. Cushing H (1932) Intracranial tumors. Charles C Thomas, Baltimore

    Google Scholar 

  13. de Divitiis E, Cappabianca P, Cavallo LM, Esposito F, de Divitiis O, Messina A (2007) Extended endoscopic transsphenoidal approach for extrasellar craniopharyngiomas. Neurosurgery 61:219–227; discussion 228

    Article  PubMed  Google Scholar 

  14. Delitala A, Brunori A, Chiappetta F (2004) Purely neuroendoscopic transventricular management of cystic craniopharyngiomas. Childs Nerv Syst 20:858–862

    Article  PubMed  Google Scholar 

  15. Derrey S, Blond S, Reyns N, Touzet G, Carpentier P, Gauthier H et al (2008) Management of cystic craniopharyngiomas with stereotactic endocavitary irradiation using colloidal 186Re: a retrospective study of 48 consecutive patients. Neurosurgery 63:1045–1052; discussion 1052–1043

    Article  PubMed  Google Scholar 

  16. Erdheim J (1904) Uber hypophysenganggeschwwuste und hirncholesteatome. Gerold, Wien

    Google Scholar 

  17. Fahlbusch R, Honegger J, Paulus W, Huk W, Buchfelder M (1999) Surgical treatment of craniopharyngiomas: experience with 168 patients. J Neurosurg 90:237–250

    Article  CAS  PubMed  Google Scholar 

  18. Fahlbusch R, Honneger J, Buchfelder M (2000) Transsphenoidal microsurgery for craniopharyngiomas. In: Schmidek HH (ed) Shmidek & sweet operative neurosurgical techniques. Indications, methods and results, vol 1. W. B. Saunders, Philadelphia, pp 503–511

    Google Scholar 

  19. Fatemi N, Dusick JR, de Paiva Neto MA, Malkasian D, Kelly DF (2009) Endonasal versus supraorbital keyhole removal of craniopharyngiomas and tuberculum sellae meningiomas. Neurosurgery 64:269–284; discussion 284–266

    Article  PubMed  Google Scholar 

  20. Frank G, Pasquini E, Doglietto F, Mazzatenta D, Sciaretta V, Farneti G et al (2006) The endoscopic extended transsphenoidal approach for craniopharyngiomas. Neurosurgery 59(suppl 1):ONS75–ONS83

    PubMed  Google Scholar 

  21. Frohlich A (1901) Ein fall von tumor der hypophysis cerebri ohne akromegalie. Wien klin Rdsch

    Google Scholar 

  22. Gardner PA, Prevedello DM, Kassam AB, Snyderman CH, Carrau RL, Mintz AH (2008) The evolution of the endonasal approach for craniopharyngiomas. J Neurosurg 108:1043–1047

    Article  PubMed  Google Scholar 

  23. Gerganov V, Metwali H, Samii A, Fahlbusch R, Samii M (2014) Microsurgical resection of extensive craniopharyngiomas using a frontolateral approach: operative technique and outcome. J Neurosurg 120:559–570

    Article  PubMed  Google Scholar 

  24. Guiot G, Derome P (1972) Indications for trans-sphenoid approach in neurosurgery. 521 cases. Ann Med Interne (Paris) 123:703–712

    CAS  Google Scholar 

  25. Halstead AE (1910) Remarks on the operative treatment of 256 tumors of the hypophysis. Surg Gynecol Obstet 10:494–502

    Google Scholar 

  26. Hoffman HJ, De Silva M, Humphreys RP, Drake JM, Smith ML, Blaser SI (1992) Aggressive surgical management of craniopharyngiomas in children. J Neurosurg 76:47–52

    Article  CAS  PubMed  Google Scholar 

  27. Hofmann BM, Kreutzer J, Saeger W, Buchfelder M, Blumcke I, Fahlbusch R et al (2006) Nuclear beta-catenin accumulation as reliable marker for the differentiation between cystic craniopharyngiomas and rathke cleft cysts: a clinico-pathologic approach. Am J Surg Pathol 30:1595–1603

    Article  PubMed  Google Scholar 

  28. Holsken A, Kreutzer J, Hofmann BM, Hans V, Oppel F, Buchfelder M et al (2009) Target gene activation of the Wnt signaling pathway in nuclear beta-catenin accumulating cells of adamantinomatous craniopharyngiomas. Brain Pathol 19:357–364

    Article  PubMed  Google Scholar 

  29. Hussain I, Eloy JA, Carmel PW, Liu JK (2013) Molecular oncogenesis of craniopharyngioma: current and future strategies for the development of targeted therapies. J Neurosurg 119:106–112

    Article  CAS  PubMed  Google Scholar 

  30. Jane JA Jr, Laws ER (2006) Craniopharyngioma. Pituitary 9:323–326

    Article  PubMed  Google Scholar 

  31. Karavitaki N (2014) Management of craniopharyngiomas. J Endocrinol Invest 37(3):219–228

    Article  CAS  PubMed  Google Scholar 

  32. Kassam AB, Gardner PA, Snyderman CH, Carrau RL, Mintz AH, Prevedello DM (2008) Expanded endonasal approach, a fully endoscopic transnasal approach for the resection of midline suprasellar craniopharyngiomas: a new classification based on the infundibulum. J Neurosurg 108:715–728

    Article  PubMed  Google Scholar 

  33. Kitano M, Taneda M (2009) Extended transsphenoidal surgery for suprasellar craniopharyngiomas: infrachiasmatic radical resection combined with or without a suprachiasmatic trans-lamina terminalis approach. Surg Neurol 71(3):290–298

    Article  PubMed  Google Scholar 

  34. Koutourousiou M, Gardner PA, Fernandez-Miranda JC, Tyler-Kabara EC, Wang EW, Snyderman CH (2013) Endoscopic endonasal surgery for craniopharyngiomas: surgical outcome in 64 patients. J Neurosurg 119(5):1194–1207

    Article  PubMed  Google Scholar 

  35. Kurosaki M, Saeger W, Ludecke DK (2001) Immunohistochemical localisation of cytokeratins in craniopharyngioma. Acta Neurochir (Wien) 143:147–151

    Article  CAS  Google Scholar 

  36. Larkin SJ, Ansorge O (2013) Pathology and pathogenesis of craniopharyngiomas. Pituitary 16:9–17

    Article  PubMed  Google Scholar 

  37. Larkin SJ, Preda V, Karavitaki N, Grossman A, Ansorge O (2014) BRAF V600E mutations are characteristic for papillary craniopharyngioma and may coexist with CTNNB1-mutated adamantinomatous craniopharyngioma. Acta Neuropathol 127:927–929

    Article  PubMed Central  PubMed  Google Scholar 

  38. Leng LZ, Greenfield JP, Souweidane MM, Anand VK, Schwartz TH (2012) Endoscopic, endonasal resection of craniopharyngiomas: analysis of outcome including extent of resection, cerebrospinal fluid leak, return to preoperative productivity, and body mass index. Neurosurgery 70:110–123; discussion 123–114

    Article  PubMed  Google Scholar 

  39. Lewis D (1910) A contribution to the subject of tumors of the hypophysis. JAMA 55:1002–1008

    Article  Google Scholar 

  40. Liu JK, Christiano LD, Gupta G, Carmel PW (2010) Surgical nuances for removal of retrochiasmatic craniopharyngiomas via the transbasal subfrontal translamina terminalis approach. Neurosurg Focus 28, E6

    Article  PubMed  Google Scholar 

  41. Liu W, Fang Y, Cai B, Xu J, You C, Zhang H (2012) Intracystic bleomycin for cystic craniopharyngiomas in children (abridged republication of cochrane systematic review). Neurosurgery 71:909–915

    Article  PubMed  Google Scholar 

  42. Minamida Y, Mikami T, Hashi K, Houkin K (2005) Surgical management of the recurrence and regrowth of craniopharyngiomas. J Neurosurg 103:224–232

    Article  PubMed  Google Scholar 

  43. Mortini P, Gagliardi F, Boari N, Losa M (2013) Surgical strategies and modern therapeutic options in the treatment of craniopharyngiomas. Crit Rev Oncol Hematol 88(3):514–529

    Article  PubMed  Google Scholar 

  44. Mott FW, Barret JO (1899) Three cases of tumor of the third ventricle. Arch Neurol 1:417–440

    Google Scholar 

  45. Muller HL, Gebhardt U, Teske C, Faldum A, Zwiener I, Warmuth-Metz M et al (2011) Post-operative hypothalamic lesions and obesity in childhood craniopharyngioma: results of the multinational prospective trial KRANIOPHARYNGEOM 2000 after 3-year follow-up. Eur J Endocrinol 165:17–24

    Article  PubMed  Google Scholar 

  46. Pascual JM, Prieto R, Castro-Dufourny I, Carrasco R, Strauss S, Barrios L (2014) Development of intracranial approaches for craniopharyngiomas: an analysis of the first 160 historical procedures. Neurosurg Focus 36, E13

    Article  PubMed  Google Scholar 

  47. Paulus W, Stockel C, Krauss J, Sorensen N, Roggendorf W (1997) Odontogenic classification of craniopharyngiomas: a clinicopathological study of 54 cases. Histopathology 30:172–176

    Article  CAS  PubMed  Google Scholar 

  48. Reisch R, Perneczky A (2005) Ten-year experience with the supraorbital subfrontal approach through an eyebrow skin incision. Neurosurgery 57:242–255

    Article  PubMed  Google Scholar 

  49. Sainte-Rose C, Puget S, Wray A, Zerah M, Grill J, Brauner R et al (2005) Craniopharyngioma: the pendulum of surgical management. Childs Nerv Syst 21:691–695

    Article  PubMed  Google Scholar 

  50. Samii M, Samii A (2000) Surgical management of craniopharyngiomas. In: Schmidek HH (ed) Schmidek & sweet operative neurosurgical techniques. Indications, methods and results, vol 1. W. B. Saunders, Philadelphia, pp 489–502

    Google Scholar 

  51. Samii M, Tatagiba M (1997) Surgical management of craniopharyngiomas: a review. Neurol Med Chir (Tokyo) 37:141–149

    Article  CAS  Google Scholar 

  52. Schloffer H (1907) Erforgleiche operationen eines hypophysentumors auf nasalem wege. Wien Klin Wochenschr 20:621–624

    Google Scholar 

  53. Sekine S, Shibata T, Kokubu A, Morishita Y, Noguchi M, Nakanishi Y et al (2002) Craniopharyngiomas of adamantinomatous type harbor beta-catenin gene mutations. Am J Pathol 161:1997–2001

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  54. Spaziante R, de Divitiis E (1997) Drainage techniques for cystic craniopharyngiomas. Neurosurg Quart 7:183–208

    Article  Google Scholar 

  55. Spaziante R, de Divitiis E, Irace C, Cappabianca P, Caputi F (1989) Management of primary or recurring grossly cystic craniopharyngiomas by means of draining systems. Topic review and 6 case reports. Acta Neurochir (Wien) 97:95–106

    Article  CAS  Google Scholar 

  56. Tateyama H, Tada T, Okabe M, Takahashi E, Eimoto T (2001) Different keratin profiles in craniopharyngioma subtypes and ameloblastomas. Pathol Res Pract 197:735–742

    Article  CAS  PubMed  Google Scholar 

  57. Van Effenterre R, Boch AL (2002) Craniopharyngioma in adults and children: a study of 122 surgical cases. J Neurosurg 97:3–11

    Article  PubMed  Google Scholar 

  58. Weiss MH (1987) The transnasal transsphenoidal approach. In: Apuzzo MLJ (ed) Surgery of the third ventricle. Williams & Wilkins, Baltimore, pp 476–494

    Google Scholar 

  59. Xin W, Rubin MA, McKeever PE (2002) Differential expression of cytokeratins 8 and 20 distinguishes craniopharyngioma from rathke cleft cyst. Arch Pathol Lab Med 126:1174–1178

    CAS  PubMed  Google Scholar 

  60. Yasargil MG, Curcic M, Kis M, Siegenthaler G, Teddy PJ, Roth P (1990) Total removal of craniopharyngiomas. Approaches and long-term results in 144 patients. J Neurosurg 73:3–11

    Article  CAS  PubMed  Google Scholar 

  61. Zenker FA (1857) Enorme Cystenbildung im Gehirn, vom Hirnanhang ausgehend. Arch Pathol Anat Physiol Klin Med 12:454–466

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Paolo Cappabianca MD .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Cappabianca, P., De Caro, M.D., Brunetti, A. (2016). Introduction. In: Cappabianca, P., Cavallo, L., de Divitiis, O., Esposito, F. (eds) Midline Skull Base Surgery. Springer, Cham. https://doi.org/10.1007/978-3-319-21533-4_5

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-21533-4_5

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-21532-7

  • Online ISBN: 978-3-319-21533-4

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics