The Role of Organosulfur Compounds Derived From Allium Vegetables in Cancer Prevention and Therapy



Organosulfur compounds (OSCs) are a group of small molecules commonly present in Allium vegetables, such as garlic, onions chives, and shallots that have garnered scientific interest for their noted health benefits. OSCs have been evaluated for their potential to prevent or treat major diseases including cancer. Epidemiological evidence of inverse association between increased intake of Allium vegetables and cancer risk is now substantiated by animal studies wherein true causal relationships between OSCs and cancer prevention have been found. This chapter summarizes the chemistry, metabolism, and bioavailability of commonly studied OSCs and the latest developments regarding their anticarcinogenic effects in cell culture and animal models. Data pertinent to clinical trials assessing safety and anticancer efficacy of OSCs are also discussed.


Prostate Cancer Cell Proliferate Cell Nuclear Antigen Reactive Oxygen Species Generation Aberrant Crypt Focus Aristolochic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.





Aristolochic acid


Alanine aminotransferase


Aspartate aminotransferase






Carbon tetrachloride


Cyclooxygenase 2


Cytochrome P450 isoenzyme 2E1


Diallyl disulfide


Diallyl sulfide


Diallyl trisulfide





DR4 and DR5

Death receptor


Extracellular signal-regulated kinase




Histone deacetylases


3-Hydroxy-3-methyl-glutaryl-Coenzyme A


Human umbilical vein endothelial cells




c-Jun N-terminal kinases




Matrix metalloprotease












Nuclear factor-κB






Organosulfur compounds


Polycyclic aromatic hydrocarbon


Phosphate-buffered saline


Proliferating cell nuclear antigen


Pomegranate fruit extract




Parts per million


Prostate-specific antigen


Phosphorylated signal transducer and activator of transcription 3


Every 3 days


Every 4 days


Every other day


Every day


Reactive Oxygen Species








Saturated sodium chloride


12-O-tetradecanoylphorbol 13-acetate


Tumor necrosis factor-related apoptosis-inducing ligand


Transgenic adenoma of a mouse prostate


Vinyl carbamate


X-linked inhibitor of apoptosis protein


Z isomer of ajoene


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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Department of Pharmaceutical Sciences, Nesbitt School of PharmacyWilkes UniversityWilkes-BarreUSA
  2. 2.Department of Pharmacology and Chemical BiologyUniversity of Pittsburgh Cancer Institute, University of Pittsburgh School of MedicinePittsburghUSA

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