Particular Antiepileptic Drugs and Foetal Malformations

  • MJ Eadie
  • FJE Vajda


This chapter attempts to discuss the published information concerning the risks of structural malformations occurring in foetuses exposed to those individual antiepileptic drugs that have been widely enough used in women with epilepsy for relevant data to be available. There appears to be persuasive evidence that valproate is a dose-related teratogen, with certain malformations such as neural tube defects seeming to be particularly associated with high maternal dosage of the drug. Evidence also points towards topiramate being a dose-related teratogen. On the basis of the available data the possibility that the remaining currently used drugs are teratogens cannot be excluded, but there appears to be enough evidence to indicate that any teratogenic hazard arising from exposure to them is quite small.


Antiepileptic Drug Foetal Malformation Malformation Rate Intrauterine Exposure Lamotrigine Monotherapy 
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© Springer International Publishing Switzerland 2016

Authors and Affiliations

  • MJ Eadie
    • 1
  • FJE Vajda
    • 2
  1. 1.Clinical Neurology and NeuropharmacologyUniversity of Queensland, and Honorary Consultant Neurologist, Royal Brisbane and Women’s HospitalBrisbaneAustralia
  2. 2.Department of Medicine and Neurology Director of the Australian Epilepsy and Pregnancy RegisterUniversity of Melbourne and Royal Melbourne HospitalMelbourneAustralia

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