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Commonly Used Newer Antiepileptic Drugs

  • MJ Eadie
  • FJE Vajda

Abstract

Data are available in the literature for the clinical pharmacologies of three newer antiepileptic drugs which have achieved a moderate amount of use in pregnant women, viz. lamotrigine, topiramate and levetiracetam. There is more information available for the first of these drugs than for the other two. The clearance value for lamotrigine, which is almost fully biotransformed to glucuronides, is considerably increased during pregnancy, with the clearances of topiramate (eliminated by a mix of metabolism and renal excretion unchanged) and levetiracetam (eliminated mainly by renal excretion without prior metabolism) being less increased. Relatively little information is available concerning the dispositions of the three drugs in the neonate, though there are published data for maternal plasma to breast milk concentration ratios.

Keywords

Antiepileptic Drug Maternal Plasma Antiepileptic Agent Lamotrigine Dose Lamotrigine Concentration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  • MJ Eadie
    • 1
  • FJE Vajda
    • 2
  1. 1.Clinical Neurology and NeuropharmacologyUniversity of Queensland, and Honorary Consultant Neurologist, Royal Brisbane and Women’s HospitalBrisbaneAustralia
  2. 2.Department of Medicine and Neurology Director of the Australian Epilepsy and Pregnancy RegisterUniversity of Melbourne and Royal Melbourne HospitalMelbourneAustralia

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