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Clinical Nuclear Medicine in Pediatrics pp 19–28Cite as

PET/MR in Children

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Abstract

The rapid increase in incidence of diagnosed malignant diseases in children over the last decades, combined with innovations in molecular oncology, neuroimaging, and hybrid imaging, has encouraged researchers and physicians to make a special effort in optimizing technological resources to approach pediatric patients using high-resolution imaging devices with concern about radiation exposure. In this context, a truly hybrid imaging tool, such as simultaneous positron emission tomography/magnetic resonance (PET/MR), presents the appealing advantage to combine serial image technology (MR) and a volumetric (PET) method, at the same time under the same conditions, to define and to assess a pathophysiological pattern for each disease in every single patient aiming to customize therapeutic strategy, therefore improving survival rate. Furthermore, a simultaneous approach enables to overcome some of the limitations of current PET/computed tomography (CT) scan, such as misregistration of attenuation (CT) and emission (PET) images due to spatial and temporal mismatch between CT and PET acquisitions, thus reducing artifactual false-positive result percentage. In addition, the possibility of matching two powerful modalities such as MR and PET opens the way for new challenging clinical applications for disease characterization that are currently under investigation, e.g., multiorgan disorders. In this chapter we will focus on the potential clinical role of PET/MR in pediatric diseases.

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Author information

Authors and Affiliations

  1. SDN Foundation, Institute of Diagnostic and Nuclear Development, Naples, Italy

    Marco Salvatore

  2. Department of Advanced Biomedical Sciences, University Federico II, Naples, Italy

    Carmela Nappi & Alberto Cuocolo

Authors
  1. Marco Salvatore
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  2. Carmela Nappi
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  3. Alberto Cuocolo
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Corresponding author

Correspondence to Marco Salvatore .

Editor information

Editors and Affiliations

  1. Nuclear Medicine, Second University of Naples, Napoli, Italy

    Luigi Mansi

  2. Nuclear Medicine, Humanitas Research Hospital, Rozzano, Milano, Italy

    Egesta Lopci

  3. Nuclear Medicine, Second University of Naples, Napoli, Italy

    Vincenzo Cuccurullo

  4. Nuclear Medicine, Humanitas Research Hospital, Rozzano, Milano, Italy

    Arturo Chiti

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© 2016 Springer International Publishing Switzerland

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Salvatore, M., Nappi, C., Cuocolo, A. (2016). PET/MR in Children. In: Mansi, L., Lopci, E., Cuccurullo, V., Chiti, A. (eds) Clinical Nuclear Medicine in Pediatrics. Springer, Cham. https://doi.org/10.1007/978-3-319-21371-2_2

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  • DOI: https://doi.org/10.1007/978-3-319-21371-2_2

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-21370-5

  • Online ISBN: 978-3-319-21371-2

  • eBook Packages: MedicineMedicine (R0)

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