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Targeting the PI3 K-mTOR Signaling Circuitry in HPV-Associated Oral Malignancies: Novel Precision Molecular Therapies

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Human Papillomavirus (HPV)-Associated Oropharyngeal Cancer

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Abstract

HPV is the most common sexually transmitted infection and it is predicted that up to 80 % of Americans will have HPV infections in their lifetime (Centers for Disease Control and Prevention 2015). The etiology of cervical cancer has long been linked with persistent HPV infection, but the correlation between HPV and other cancer types, including head and neck squamous cell carcinomas (HNSCC), oropharyngeal carcinomas (OPCs), anal carcinomas, and cancers of the genital tract is emerging (Forman et al. 2012). Compared to alcohol- and tobacco-related HNSCC, HPV-associated head and neck cancer involves activation of specific molecular mechanisms, making HPV(+) HNSCCs diagnostically and therapeutically distinct. Here, we will review the current understanding of the molecular mechanisms in HPV(+) HNSCC with emphasis on the signaling events that drive the growth of HPV-associated HNSCC and the emerging opportunities for the development of novel precision molecular-targeted therapies for this disease.

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Acknowledgments

Work in the author’(s) laboratory is supported by the Intramural Research Program of the NIH, NIDCR.

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Authors and Affiliations

  1. Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Building 30, Rm 320, Bethesda, MD, 20892, USA

    Colleen L. Doçi & J. Silvio Gutkind

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  1. Colleen L. Doçi
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  2. J. Silvio Gutkind
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Correspondence to J. Silvio Gutkind .

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Editors and Affiliations

  1. School of Medicine, University of Missouri, Columbia, Missouri, USA

    Daniel L. Miller

  2. Department of Chemistry and Biochemistry, Harper Cancer Research Institute, University of Notre Dame, South Bend, Indiana, USA

    M. Sharon Stack

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Doçi, C.L., Gutkind, J.S. (2015). Targeting the PI3 K-mTOR Signaling Circuitry in HPV-Associated Oral Malignancies: Novel Precision Molecular Therapies. In: Miller, D., Stack, M. (eds) Human Papillomavirus (HPV)-Associated Oropharyngeal Cancer. Springer, Cham. https://doi.org/10.1007/978-3-319-21100-8_7

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