Lung Vasculogenesis and Angiogenesis

Part of the Stem Cell Biology and Regenerative Medicine book series (STEMCELL)

Abstract

The pulmonary vasculature remains the poor cousin of lung development. Evidence has challenged old notions that the development of blood vessels in the lung passively follows that of the airways. Rather, lung blood vessels actively promote alveolar growth during development and contribute to the maintenance of alveolar structures throughout postnatal life. These observations may be relevant for lung diseases characterized by arrested alveolar growth or loss of alveoli. This review summarizes the role of angiogenic growth factors during normal alveolar development, injury, and repair and identifies gaps in our understanding of lung vasculogenesis and angiogenesis.

Keywords

Angiogenesis Vasculogenesis Lung Development Injury Aging Oxygen 

Notes

Acknowledgments

B.T. is supported by the Canadian Institutes for Health Research (CIHR), the Ontario Thoracic Society, the Canadian Stem Cell Network, the Children’s Hospital of Eastern Ontario Research Institute and the Ottawa Hospital Research Institute. M.Y. is supported in part by the Riley Children’s Foundation.

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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  1. 1.Division of Neonatology, Department of PediatricsSinclair Centre for Regenerative Medicine, Ottawa Hospital Research Institute, Children’s Hospital of Eastern Ontario, University of OttawaOttawaCanada
  2. 2.Department of Pediatrics, Wells Center for Pediatric ResearchIndiana University School of MedicineIndianapolisUSA

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