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Clinical Use of OCT and MSON Mimics

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Optical Coherence Tomography in Multiple Sclerosis

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Abstract

The differential diagnosis and mimics of multiple sclerosis-associated optic neuritis (MSON) are categorized as MSON mimics such as isolated optic neuritis (ION), relapsing isolated optic neuritis (RION), chronic relapsing inflammatory optic neuropathy (CRION), and neuromyelitis optica optic neuritis (NMO-ON). The differential diagnosis also includes infectious, reactive, vascular, nutritional and toxic, compressive, systemic disease, ocular, hereditary, and miscellaneous etiologies.

Retinal optical coherence tomography (OCT) helps with the differential diagnosis. Pictures of 31 of the authors’ own cases are presented such that this chapter provides an illustrative atlas of OCT images directly relevant for clinical practice. Characteristic OCT features are discussed.

This chapter is aimed at clinicians who wish to acquire an overview of OCT imaging as well as to serve as a lookup reference.

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References

  1. Petzold A, Wattjes MP, Costello F, et al. The investigation of acute optic neuritis: a review and proposed protocol. Nat Rev Neurol. 2014;10:447–58.

    Article  PubMed  Google Scholar 

  2. Plant G. Optic neuritis and multiple sclerosis. Curr Opin Neurol. 2008;21:16–21.

    Article  PubMed  Google Scholar 

  3. Spaide RF, Curcio CA. Anatomical correlates to the bands seen in the outer retina by optical coherence tomography: literature review and model. Retina (Philadelphia, Pa). 2011;31:1609–19.

    Article  Google Scholar 

  4. Brex P, Ciccarelli O, O’Riordan J, et al. A longitudinal study of abnormalities on MRI and disability from multiple sclerosis. N Engl J Med. 2002;346:158–64.

    Article  PubMed  Google Scholar 

  5. Petzold A, Pittock S, Lennon V, et al. Neuromyelitis optica-IgG (aquaporin-4) autoantibodies in immune mediated optic neuritis. J Neurol Neurosurg Psychiatry. 2010;81:109–11.

    Article  CAS  PubMed  Google Scholar 

  6. Petzold A, Plant GT. Chronic relapsing inflammatory optic neuropathy: a systematic review of 122 cases reported. J Neurol. 2014;261:17–26.

    Article  PubMed  Google Scholar 

  7. Plant GT, Sibtain NA, Thomas D. Hyperacute corticosteroid treatment of optic neuritis at the onset of pain may prevent visual loss: a case series. Mult Scler Int. 2011;2011:815068.

    PubMed Central  CAS  PubMed  Google Scholar 

  8. Wingerchuk DM, Lennon VA, Lucchinetti CF, et al. The spectrum of neuromyelitis optica. Lancet Neurol. 2007;6:805–15.

    Article  CAS  PubMed  Google Scholar 

  9. Costello F, Hodge W, Pan YI, et al. Tracking retinal nerve fiber layer loss after optic neuritis: a prospective study using optical coherence tomography. Mult Scler. 2008;14:893–905.

    Article  CAS  PubMed  Google Scholar 

  10. Kidd D. The optic chiasm. Handb Clin Neurol. 2011;102:185–203.

    Article  PubMed  Google Scholar 

  11. Frohman L, Frieman B, Wolansky L. Reversible blindness resulting from optic chiasmitis secondary to systemic lupus erythematosus. J Neuroophthalmol. 2001;21:18–21.

    Article  CAS  PubMed  Google Scholar 

  12. Apkarian P, Bour LJ, Barth PG, et al. Non-decussating retinal-fugal fibre syndrome. An inborn achiasmatic malformation associated with visuotopic misrouting, visual evoked potential ipsilateral asymmetry and nystagmus. Brain. 1995;118(Pt 5):1195–216.

    Article  PubMed  Google Scholar 

  13. Bessero A-C, Plant GT. Should ‘visual snow’ and persistence of after-images be recognised as a new visual syndrome? J Neurol Neurosurg Psychiatry. 2014;85:1057–8.

    Article  PubMed  Google Scholar 

  14. Burggraaff MC, Trieu J, de Vries-Knoppert WA, et al. The clinical spectrum of microcystic macular oedema. Invest Ophthalmol Vis Sci. 2014;55:952–61.

    Article  PubMed  Google Scholar 

  15. Gelfand JM, Cree BA, Nolan R, et al. Microcystic inner nuclear layer abnormalities and neuromyelitis optica. JAMA Neurol. 2013;70:629–33.

    Article  PubMed  Google Scholar 

  16. Parsa CF, Hoyt WF. Nonarteritic anterior ischemic optic neuropathy (NAION): a misnomer. Rearranging pieces of a puzzle to reveal a nonischemic papillopathy caused by vitreous separation. Ophthalmology. 2015;122:439–42.

    Article  PubMed  Google Scholar 

  17. Kupersmith MJ, Anderson S, Durbin MK, Kardon RH. Scanning laser polarimetry, but not optical coherence tomography predicts permanent visual field loss in acute non-arteritic anterior ischemic optic neuropathy. Invest Ophthalmol Vis Sci. 2013;54:5514–9.

    Article  PubMed Central  PubMed  Google Scholar 

  18. Petzold A, Islam N, Hu H-H, Plant GT. Embolic and nonembolic transient monocular visual field loss: a clinicopathologic review. Surv Ophthalmol. 2013;58:42–62.

    Article  PubMed  Google Scholar 

  19. Grutzendler J, Murikinati S, Hiner B, et al. Angiophagy prevents early embolus washout but recanalizes microvessels through embolus extravasation. Sci Transl Med. 2014;6:226ra31.

    Article  PubMed  Google Scholar 

  20. Khan J, Chong V. Two retinal vein occlusions in a patient with venous tortuosity at the optic disc. Graefes Arch Clin Exp Ophthalmol. 2007;245:313–4.

    Article  PubMed  Google Scholar 

  21. Jindahra P, Petrie A, Plant GT. Retrograde trans-synaptic retinal ganglion cell loss identified by optical coherence tomography. Brain. 2009;132:628–34.

    Article  PubMed  Google Scholar 

  22. Jindahra P, Petrie A, Plant GT. The time course of retrograde trans-synaptic degeneration following occipital lobe damage in humans. Brain. 2012;135:534–41.

    Article  PubMed  Google Scholar 

  23. Kidd D, Beynon HLC. The neurological complications of systemic sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis. 2003;20:85–94.

    PubMed  Google Scholar 

  24. Scott TF, Yandora K, Kunschner LJ, Schramke C. Neurosarcoidosis mimicry of multiple sclerosis: clinical, laboratory, and imaging characteristics. Neurologist. 2010;16:386–9.

    Article  PubMed  Google Scholar 

  25. Bonfioli AA, Damico FM, Curi ALL, Orefice F. Intermediate uveitis. Semin Ophthalmol. 2005;20:147–54.

    Article  PubMed  Google Scholar 

  26. Matsuoka M, Ogata N, Takahashi K, et al. Two cases of ocular sarcoidosis in which vitreous cytology was useful for supporting the diagnosis. Clin Ophthalmol. 2012;6:1207–9.

    Article  PubMed Central  PubMed  Google Scholar 

  27. Achiron L, Strominger M, Witkin N, Primo S. Sarcoid optic neuropathy: a case report. J Am Optom Assoc. 1995;66:646–51.

    CAS  PubMed  Google Scholar 

  28. Horwitz H, Friis T, Modvig S, et al. Differential diagnoses to MS: experiences from an optic neuritis clinic. J Neurol. 2014;261:98–105.

    Article  PubMed  Google Scholar 

  29. Hamed L, Glaser J, Gass J, Schatz N. Protracted enlargement of the blind spot in multiple evanescent white dot syndrome. Arch Ophthalmol. 1989;107:194–8.

    Article  CAS  PubMed  Google Scholar 

  30. Abegg M, Dysli M, Wolf S, et al. Microcystic macular edema: retrograde maculopathy caused by optic neuropathy. Ophthalmology. 2014;121:142–9.

    Article  PubMed  Google Scholar 

  31. Mahroo OA, Shalchi Z, Kisimbi J, et al. Re: Abegg et al.: Microcystic macular edema: retrograde maculopathy caused by optic neuropathy. Ophthalmology. 2014;121:142–9 (Ophthalmology 2014;121:e40).

    Google Scholar 

  32. Balk LJ, Twisk JWR, Steenwijk MD, et al. A dam for retrograde axonal degeneration in multiple sclerosis? J Neurol Neurosurg Psychiatry. 2014;85:782–9.

    Article  CAS  PubMed  Google Scholar 

  33. Marziani E, Pomati S, Ramolfo P, et al. Evaluation of retinal nerve fiber layer and ganglion cell layer thickness in Alzheimer’s disease using spectral-domain optical coherence tomography. Invest Ophthalmol Vis Sci. 2013;54:5953–8.

    Article  PubMed  Google Scholar 

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Acknowledgment

We are grateful for discussions with Dr. Willemien Vries-Knoppert and Professor Stevie Tan. We would like to thank Dr. Yvonne Yong-Heesen (MEWDS) and Dr. Stefan Elferink (neuroretinitis) for sharing their cases.

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Authors and Affiliations

  1. Department of Neuro-ophthalmology, Moorfields Eye Hospital & National Hospital of Neurology and Neurosurgery, London, UK

    Axel Petzold MD, PhD

  2. Department of Neuroimmunology, UCL Institute of Neurology, London, UK

    Axel Petzold MD, PhD

  3. Dutch Expertise Center Neuro-Ophthalmology, Departments of Neurology and Ophthalmology, VU Medical Center, Amsterdam, The Netherlands

    Axel Petzold MD, PhD

  4. Department of Neuro-ophthalmology, Moorfields Eye Hospital, St. Thomas’ Hospital, National Hospital for Neurology and Neurosurgery, London, UK

    Gordon T. Plant MA, MD, FRCP, FRCOphth

Authors
  1. Axel Petzold MD, PhD
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  2. Gordon T. Plant MA, MD, FRCP, FRCOphth
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Corresponding author

Correspondence to Axel Petzold MD, PhD .

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Editors and Affiliations

  1. Department of Neuroimmunology, VU Medical Center, Expertise Center Neuro-ophthalmology, Departments of Neurology and Ophthalmology, Amsterdam, The Netherlands, Moorfields Eye Hospital, Department of Neuro-Ophthalmology, London, UK, UCL Institute of Neurology, London, United Kingdom

    Axel Petzold

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© 2016 Springer International Publishing Switzerland

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Petzold, A., Plant, G.T. (2016). Clinical Use of OCT and MSON Mimics. In: Petzold, A. (eds) Optical Coherence Tomography in Multiple Sclerosis. Springer, Cham. https://doi.org/10.1007/978-3-319-20970-8_5

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  • DOI: https://doi.org/10.1007/978-3-319-20970-8_5

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-20969-2

  • Online ISBN: 978-3-319-20970-8

  • eBook Packages: MedicineMedicine (R0)

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