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Echocardiographic Signs of Ischemia

  • Chapter
Stress Echocardiography

Abstract

The response of left ventricular function to ischemia is monotonous and independent of the stress employed [1]. The same echocardiographic signs can be found in transient ischemia and acute infarction. The difference lies in the time sequence, and from an echocardiographic viewpoint, myocardial ischemia is a “reversible” myocardial infarction. The cardinal sign of ischemia is the transient, regional wall motion abnormality – the cornerstone of diagnosis. There are other ancillary signs of severity which may occasionally help in disease severity stratification, such as left ventricular cavity dilation, acute severe mitral insufficiency, fall of stroke volume, and the appearance of ultrasound B-lines in the chest. In cutting-edge stress echocardiography environments, today wall motion analysis can be coupled during vasodilator stress with assessment of coronary flow reserve – further expanding our diagnostic and prognostic information during stress echocardiography.

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References

  1. Picano E (1992) Stress echocardiography. From pathophysiological toy to diagnostic tool. Circulation 85:1604–1612

    Article  CAS  PubMed  Google Scholar 

  2. Ross J Jr (1991) Myocardial perfusion-contraction matching. Implications for coronary heart disease and hibernation. Circulation 83:1076–1083

    Article  PubMed  Google Scholar 

  3. Arnese M, Fioretti PM, Cornel JH et al (1994) Akinesis becoming dyskinesis during high-dose dobutamine stress echocardiography: a marker of myocardial ischemia or a mechanical phenomenon? Am J Cardiol 73:896–899

    Article  CAS  PubMed  Google Scholar 

  4. Chen C, Li L, Chen LL et al (1995) Incremental doses of dobutamine induce a biphasic response in dysfunctional left ventricular regions subtending coronary stenoses. Circulation 92:756–766

    Article  CAS  PubMed  Google Scholar 

  5. Gibbons RJ, Chatterjee K, Daley J et al (1999) ACC/AHA/ACP-ASIM guidelines for the management of patients with chronic stable angina: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Management of Patients With Chronic Stable Angina). J Am Coll Cardiol 33:2092–2197

    Article  CAS  PubMed  Google Scholar 

  6. Sheikh KH, Bengtson JR, Helmy S et al (1990) Relation of quantitative coronary lesion measurements to the development of exercise-induced ischemia assessed by exercise echocardiography. J Am Coll Cardiol 15:1043–1051

    Article  CAS  PubMed  Google Scholar 

  7. Picano E, Parodi O, Lattanzi F et al (1994) Assessment of anatomic and physiological severity of single-vessel coronary artery lesions by dipyridamole echocardiography. Comparison with positron emission tomography and quantitative arteriography. Circulation 89:753–761

    Article  CAS  PubMed  Google Scholar 

  8. Cortigiani L, Picano E, Landi P et al (1998) Value of pharmacologic stress echocardiography in risk stratification of patients with single-vessel disease: a report from the Echo-Persantine and Echo-Dobutamine International Cooperative Studies. J Am Coll Cardiol 32:69–74

    Article  CAS  PubMed  Google Scholar 

  9. Lattanzi F, Picano E, Bolognese L et al (1991) Inhibition of dipyridamole-induced ischemia by antianginal therapy in humans. Correlation with exercise electrocardiography. Circulation 83:1256–1262

    Article  CAS  PubMed  Google Scholar 

  10. Ferrara N, Longobardi G, Nicolino A et al (1992) Effect of beta-adrenoceptor blockade on dipyridamole-induced myocardial asynergies in coronary artery disease. Am J Cardiol 70:724–727

    Article  CAS  PubMed  Google Scholar 

  11. Dodi C, Pingitore A, Sicari R et al (1997) Effects of antianginal therapy with a calcium antagonist and nitrates on dobutamine-atropine stress echocardiography. Comparison with exercise electrocardiography. Eur Heart J 18:242–247

    Article  CAS  PubMed  Google Scholar 

  12. San Roman JA, Vilacosta I, Castillo JA et al (1996) Dipyridamole and dobutamine-atropine stress echocardiography in the diagnosis of coronary artery disease. Comparison with exercise stress test, analysis of agreement, and impact of antianginal treatment. Chest 110:1248–1254

    Article  CAS  PubMed  Google Scholar 

  13. Nagel E, Lehmkuhl HB, Bocksch W et al (1999) Noninvasive diagnosis of ischemia-induced wall motion abnormalities with the use of high-dose dobutamine stress MRI: comparison with dobutamine stress echocardiography. Circulation 99:763–770

    Article  CAS  PubMed  Google Scholar 

  14. Thomas D, Xie F, Smith LM, O'Leary E et al (2012) Prospective randomized comparison of conventional stress echocardiography and real-time perfusion stress echocardiography in detecting significant coronary artery disease. J Am Soc Echocardiogr 25:1207–1214

    Article  PubMed  Google Scholar 

  15. Gaibazzi N, Rigo F, Reverberi C (2010) Detection of coronary artery disease by combined assessment of wall motion, myocardial perfusion and coronary flow reserve: a multiparametric contrast stress-echocardiography study. J Am Soc Echocardiogr 23:1242–1250

    Article  PubMed  Google Scholar 

  16. Elhendy A, O'Leary EL, Xie F, McGrain AC, Anderson JR, Porter TR (2004) Comparative accuracy of real-time myocardial contrast perfusion imaging and wall motion analysis during dobutamine stress echocardiography for the diagnosis of coronary artery disease. J Am Coll Cardiol 44:2185–2191

    Article  PubMed  Google Scholar 

  17. Specchia G, de Servi S, Falcone C et al (1981) Significance of exercise-induced ST-segment elevation in patients without myocardial infarction. Circulation 63:46–53

    Article  CAS  PubMed  Google Scholar 

  18. Kawano H, Fuji H (1995) Induction of coronary spasm during dobutamine stress echocardiography. Circulation 92:1–89

    Article  Google Scholar 

  19. Varga A, Cortigiani L, Rossi PC et al (1999) Coronary vasospasm as a source of false positive results during dobutamine echocardiography. Cardiologia 44:907–912

    CAS  PubMed  Google Scholar 

  20. Picano E, Lattanzi F, Masini M et al (1988) Aminophylline termination of dipyridamole stress as a trigger of coronary vasospasm in variant angina. Am J Cardiol 62:694–697

    Article  CAS  PubMed  Google Scholar 

  21. Spes CH, Mudra H, Schnaack SD et al (1996) Dobutamine stress echocardiography for noninvasive diagnosis of cardiac allograft vasculopathy: a comparison with angiography and intravascular ultrasound. Am J Cardiol 78:168–174

    Article  CAS  PubMed  Google Scholar 

  22. Franchini M, Traversi E, Cannizzaro G et al (2000) Dobutamine stress echocardiography and thallium-201 SPECT for detecting ischaemic dilated cardiomyopathy in patients with heart failure. Eur J Echocardiogr 1:109–115

    Article  CAS  PubMed  Google Scholar 

  23. Bach DS, Muller DW, Gros BJ et al (1994) False positive dobutamine stress echocardiograms: characterization of clinical, echocardiographic and angiographic findings. J Am Coll Cardiol 24:928–933

    Article  CAS  PubMed  Google Scholar 

  24. Baroni M, Maffei S, Terrazzi M et al (1996) Mechanisms of regional ischaemic changes during dipyridamole echocardiography in patients with severe aortic valve stenosis and normal coronary arteries. Heart 75:492–497

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  25. Picano E, Palinkas A, Amyot R (2001) Diagnosis of myocardial ischemia in hypertensive patients. J Hypertens 19:1177–1183

    Article  CAS  PubMed  Google Scholar 

  26. Rajappan K, Rimoldi OE, Dutka DP et al (2002) Mechanisms of coronary microcirculatory dysfunction in patients with aortic stenosis and angiographically normal coronary arteries. Circulation 105:470–476

    Article  PubMed  Google Scholar 

  27. Ha JW, Juracan EM, Mahoney DW et al (2002) Hypertensive response to exercise: a potential cause for new wall motion abnormality in the absence of coronary artery disease. J Am Coll Cardiol 39:323–327

    Article  PubMed  Google Scholar 

  28. Beker B, Vered Z, Bloom NV et al (1994) Decreased thickening of normal myocardium with transient increased wall thickness during stress echocardiography with atrial pacing. J Am Soc Echocardiogr 7:381–387

    Article  CAS  PubMed  Google Scholar 

  29. Hirshleifer J, Crawford M, O’Rourke RA et al (1975) Influence of acute alterations in heart rate and systemic arterial pressure on echocardiographic measures of left ventricular performance in normal human subjects. Circulation 52:835–841

    Article  CAS  PubMed  Google Scholar 

  30. Borges AC, Pingitore A, Cordovil A et al (1995) Heterogeneity of left ventricular regional wall thickening following dobutamine infusion in normal human subjects. Eur Heart J 16:1726–1730

    CAS  PubMed  Google Scholar 

  31. Carstensen S, Ali SM, Stensgaard-Hansen FV et al (1995) Dobutamine-atropine stress echocardiography in asymptomatic healthy individuals. The relativity of stress-induced hyperkinesia. Circulation 92:3453–3463

    Article  CAS  PubMed  Google Scholar 

  32. Abdelmoneim SS, Mankad SV, Bernier M et al (2009) (2009) Microvascular function in Takotsubo cardiomyopathy with contrast echocardiography: prospective evaluation and review of literature. J Am Soc Echocardiogr 22:1249–1255

    Article  PubMed  Google Scholar 

  33. Sicari R, Palinkas A, Pasanisi E et al (2005) Long-term survival of patients with chest pain syndrome and angiographically normal or near-normal coronary arteries: the additional prognostic value of dipyridamole echocardiography test (DET). Eur Heart J 26:2136–2141

    Article  PubMed  Google Scholar 

  34. Harrison MR, Smith MD, Friedman BJ et al (1987) Uses and limitations of exercise Doppler echocardiography in the diagnosis of ischemic heart disease. J Am Coll Cardiol 10:809–817

    Article  CAS  PubMed  Google Scholar 

  35. Agati L, Arata L, Neja CP et al (1990) Usefulness of the dipyridamole-Doppler test for diagnosis of coronary artery disease. Am J Cardiol 65:829–834

    Article  CAS  PubMed  Google Scholar 

  36. Olson CE, Porter TR, Deligonul U et al (1994) Left ventricular volume changes during dobutamine stress echocardiography identify patients with more extensive coronary artery disease. J Am Coll Cardiol 24:1268–1273

    Article  CAS  PubMed  Google Scholar 

  37. Zachariah ZP, Hsiung MC, Nanda NC et al (1987) Color Doppler assessment of mitral regurgitation induced by supine exercise in patients with coronary artery disease. Am J Cardiol 59:1266–1270

    Article  CAS  PubMed  Google Scholar 

  38. Pierard LA, Lancellotti P (2006) Dyspnea and stress testing. N Engl J Med 354:871–873

    Article  CAS  PubMed  Google Scholar 

  39. Picano E, Frassi F, Agricola E et al (2006) Ultrasound lung comets: a clinically useful sign of extravascular lung water. J Am Soc Echocardiogr 19:356–363

    Article  PubMed  Google Scholar 

  40. Agricola E, Picano E, Oppizzi M et al (2006) Assessment of stress-induced pulmonary interstitial edema by chest ultrasound during exercise echocardiography and its correlation with left ventricular function. J Am Soc Echocardiogr 19:457–463

    Article  PubMed  Google Scholar 

  41. Ristow B, Ali S, Ren X, Whooley MA, Schiller NB (2007) Elevated pulmonary artery pressure by Doppler echocardiography predicts hospitalization for heart failure and mortality in ambulatory stable coronary artery disease: the Heart and Soul Study. J Am Coll Cardiol 49:43–49

    Article  PubMed Central  PubMed  Google Scholar 

  42. Sicari R, Nihoyannopoulos P, Evangelista A et al (2008) Stress echocardiography expert consensus statement: European Association of Echocardiography (EAE) (a registered branch of the ESC). Eur J Echocardiogr 9:415–437

    Article  PubMed  Google Scholar 

  43. Zoghbi GJ, Dorfman TA, Iskandrian AE (2008) The effects of medications on myocardial perfusion. J Am Coll Cardiol 52:401–416

    Article  CAS  PubMed  Google Scholar 

  44. Gaibazzi N, Reverberi C, Lorenzoni V, Molinaro V, Porter TR (2011) Prognostic value of high dose dipyridamole stress myocardial contrast perfusion echocardiography. Circulation 126:1182–1184

    Google Scholar 

  45. Tsutsui JM, Elhendy A, Anderson JR et al (2005) Prognostic value of dobutamine stress myocardial contrast perfusion echocardiography. Circulation 112:1444–1450

    Article  PubMed  Google Scholar 

  46. Rigo F, Sicari R, Gherardi S et al (2008) The additive prognostic value of wall motion abnormalities and coronary flow reserve during dipyridamole stress echo. Eur Heart J 29:79–88

    Article  PubMed  Google Scholar 

  47. Hoffmann R, von Bardeleben S, Kasprzak JD et al (2006) Analysis of regional left ventricular function by cineventriculography, cardiac magnetic resonance imaging, and unenhanced and contrast-enhanced echocardiography: a multicenter comparison of methods. J Am Coll Cardiol 47:121–128

    Article  PubMed  Google Scholar 

  48. Moir S, Shaw L, Haluska B et al (2007) Left ventricular opacification for the diagnosis of coronary artery disease with stress echocardiography: an angiographic study of incremental benefit and cost-effectiveness. Am Heart J 154:510–518

    Article  PubMed  Google Scholar 

  49. Skyba DM, Camarano G, Goodman NC et al (1996) Hemodynamic characteristics, myocardial kinetics, and microvascular rheology of FS-069, a second-generation echocardiographic contrast agent capable of producing myocardial opacification from a venous injection. J Am Coll Cardiol 28:1292–1300

    Article  CAS  PubMed  Google Scholar 

  50. Lindner JR, Firschke C, Wei K et al (1998) Myocardial perfusion characteristics and hemodynamic profile of MRX-115, a venous echocardiographic contrast agent, during acute myocardial infarction. J Am Soc Echocardiogr 11:36–46

    Article  CAS  PubMed  Google Scholar 

  51. Jayaweera AR, Edwards N, Glasheen WP et al (1994) In-vivo myocardial kinetics of air-filled albumin microbubbles during myocardial contrast echocardiography: comparison with radiolabeled red blood cells. Circ Res 74:1157–1165

    Article  CAS  PubMed  Google Scholar 

  52. Wei K, Skyba DM, Firschke C et al (1997) Interaction between microbubbles and ultrasound: in vitro and in vivo observations. J Am Coll Cardiol 29:1081–1088

    Article  CAS  PubMed  Google Scholar 

  53. Kaul S (2002) Instrumentation for contrast echocardiography: technology and techniques. Am J Cardiol 90:8J–14J

    Article  PubMed  Google Scholar 

  54. Pathan F, Marwick TH (2015) Myocardial perfusion imaging using contrast echocardiography. Prog Cardiovasc Dis 57:632–643

    Article  PubMed  Google Scholar 

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Correspondence to Nicola Gaibazzi PhD .

Table of Contents Video Companion

Table of Contents Video Companion

  • See stress echo primer, case 6 (intracoronary contrast stress echo).

  • See also in section “Illustrative cases: Case numbers 26, 27, and 28” (by Nicola Gaibazzi, MD, Parma, Italy).

  • Springer Extra Materials available at http://extras.springer.com/2015/978-3-319-20957-9

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Gaibazzi, N., Picano, E. (2015). Echocardiographic Signs of Ischemia. In: Stress Echocardiography. Springer, Cham. https://doi.org/10.1007/978-3-319-20958-6_6

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  • DOI: https://doi.org/10.1007/978-3-319-20958-6_6

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-20957-9

  • Online ISBN: 978-3-319-20958-6

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