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Microscale Technologies for Cell Engineering pp 3–25Cite as

Microscale Technologies for Engineering Complex Tissue Structures

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Abstract

Engineered tissue scaffolds aim to reproduce the body’s architectural and geometrical intricacies, including vital cell–cell interactions. These scaffolds serve as synthetic extracellular matrices that organize the embedded cells into a three-dimensional (3D) architecture and present them with stimuli for their growth and maturation. Tissue engineering techniques have been applied to many types of tissues; however, numerous challenges regarding their development still remain. These challenges include our inability to generate a functional vasculature that can supply the tissue with nutrients and oxygen and the inability to mimic the complex cell–microenvironmental interactions that regulate the formation of a functional tissue. This chapter focuses on the most recent developments in the field of microfabrication technologies to design vascularized tissue constructs. In particular, we discuss emerging bottom-up approaches to design complex macroscale structures, examine their current limitations, and conclude with future directions in designing more complex tissue architecture.

Keywords

  • Microscale technologies
  • Tissue engineering
  • Vascularized tissues
  • Bioprinting
  • Complex tissues

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Authors and Affiliations

  1. Department of Biomedical Engineering, Texas A&M University, College Station, TX, 77843, USA

    Charles W. Peak, Lauren Cross & Akhilesh K. Gaharwar

  2. Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY, 14853, USA

    Ankur Singh

  3. Department of Materials Science and Engineering, Texas A&M University, College Station, TX, 77843, USA

    Akhilesh K. Gaharwar

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  1. Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, New York, USA

    Ankur Singh

  2. Eng & Dept of Material Science and Eng, Texas A&M University, Dept of Biomedical, College Station, Texas, USA

    Akhilesh K. Gaharwar

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Peak, C.W., Cross, L., Singh, A., Gaharwar, A.K. (2016). Microscale Technologies for Engineering Complex Tissue Structures. In: Singh, A., Gaharwar, A. (eds) Microscale Technologies for Cell Engineering. Springer, Cham. https://doi.org/10.1007/978-3-319-20726-1_1

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