Nonalcoholic Fatty Liver Disease: Clinical Features, Disease Modifiers, and Natural History

  • Dawn M. Torres
  • Stephen A. HarrisonEmail author


Nonalcoholic fatty liver disease (NAFLD) typically presents as an asymptomatic elevation of liver-associated enzymes and has been associated with a number of clinical conditions that are included in the definition of the metabolic syndrome such as obesity, hyperlipidemia, and insulin resistance. NAFLD also has been shown to be related to a variety of conditions such as cardiovascular disease and obstructive sleep apnea. This review will address the clinical presentation and natural history of NAFLD as the hepatic manifestation of the metabolic syndrome.


NAFLD Natural history Steatohepatitis Obstructive sleep apnea Diabetes mellitus Obesity 



The opinion or assertions contained herein are the private views of the authors and are not to be construed as official or reflecting the view of the US Department of the Army or the US Department of Defense.

Grant Support



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© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Division of Gastroenterology, Department of MedicineWalter Reed National Military Medical CenterBethesdaUSA
  2. 2.Division of Gastroenterology and Hepatology, Department of MedicineSan Antonio Military Medical CenterFort Sam HoustonUSA

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