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Pathology of Alcoholic and Nonalcoholic Fatty Liver Disease

  • Pierre Bedossa
  • David E. KleinerEmail author

Abstract

Nonalcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD) are two of the most common pathologies to affect the liver. They share many of the same features, including steatosis (the accumulation of fat droplets in hepatocytes), inflammation, ballooning injury, Mallory–Denk bodies, and fibrosis that can progress to cirrhosis. Although there are similarities, they are etiologically and pathogenetically distinct entities, and these issues have been addressed in other chapters. There are also differences in the character of the pathology between NAFLD and ALD. Both of these diseases may manifest in different patterns of injury, and recognition of these specific patterns still requires invasive testing through liver biopsy. In the sections that follow, the pathological manifestations of NAFLD and ALD are discussed, along with the grading and staging systems that are used in clinical management.

Keywords

Liver histology NAFLD Activity Score NAS Nonalcoholic steatohepatitis: ballooning Mallory–Denk bodies Steatosis Perisinusoidal fibrosis 

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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Hôpitaux Universitaires Paris Nord Val de Seine, Département d’Anatomie Pathologique, Hôpital Beaujon – INSERM U1149Université Paris Diderot, UFR de médecineParisFrance
  2. 2.Laboratory of PathologyNCIBethesdaUSA

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