Skip to main content

Optimal Treatment for Papillary Microcarcinoma

  • Chapter
Controversies in Thyroid Surgery

Abstract

The dramatic increase in the detection and diagnosis of papillary microcarcinomas has resulted in a huge increase in the number of thyroid cancer surgeries being done for very low-risk disease. While thyroid surgery is the cornerstone of the management of clinically significant thyroid cancer, the very low-risk nature of papillary microcarcinoma and the successful use of an active surveillance management approach by our Japanese colleagues have caused many clinicians and patients to question whether or not an immediate surgical approach to initial management is warranted in all cases. In this chapter we will review the risk factors associated with disease progression in papillary microcarcinoma, the expected outcomes after surgical resection, and the outcomes associated with active surveillance. Finally, we will provide clinical guidance with regard to proper selection of patients for either an immediate surgical management approach or an active surveillance observational management approach to very low-risk thyroid cancer.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 54.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Enewold L, Zhu K, Ron E, et al. Rising thyroid cancer incidence in the United States by demographic and tumor characteristics, 1980–2005. Cancer Epidemiol Biomarkers Prev. 2009;18:784–91. doi:10.1158/1055-9965.EPI-08-0960.

    Article  PubMed Central  PubMed  Google Scholar 

  2. Davies L, Welch HG. Increasing incidence of thyroid cancer in the United States, 1973–2002. JAMA. 2006;295:2164–7. doi:10.1001/jama.295.18.2164.

    Article  CAS  PubMed  Google Scholar 

  3. Davies L, Welch HG. Current thyroid cancer trends in the United States. JAMA Otolaryngol Head Neck Surg. 2014;140:317–22. doi:10.1001/jamaoto.2014.1.

    Article  PubMed  Google Scholar 

  4. Leenhardt L, Bernier MO, Boin-Pineau MH, et al. Advances in diagnostic practices affect thyroid cancer incidence in France. Eur J Endocrinol. 2004;150:133–9. doi:10.1530/eje.0.1500133.

    Article  CAS  PubMed  Google Scholar 

  5. Rego-Iraeta A, Pérez-Méndez LF, Mantinan B, Garcia-Mayor RV. Time trends for thyroid cancer in Northwestern Spain: true rise in the incidence of micro and larger forms of papillary thyroid carcinoma. Thyroid. 2009;19:333–40. doi:10.1089/thy.2008.0210.

    Article  PubMed  Google Scholar 

  6. Ito Y, Miyauchi A. A therapeutic strategy for incidentally detected papillary microcarcinoma of the thyroid. Nat Clin Pract Endocrinol Metab. 2007;3:240–8. doi:10.1038/ncpendmet0428.

    Article  PubMed  Google Scholar 

  7. Roti E, Degli Uberti EC, Bondanelli M, Braverman LE. Thyroid papillary microcarcinoma: a descriptive and meta-analysis study. Eur J Endocrinol. 2008;159:659–73. doi:10.1530/EJE-07-0896.

    Article  CAS  PubMed  Google Scholar 

  8. Londero SC, Krogdahl A, Bastholt L, et al. Papillary thyroid carcinoma in Denmark 1996–2008: an investigation of changes in incidence. Cancer Epidemiol. 2013;37:e1–6. doi:10.1016/j.canep.2012.10.011.

    Article  PubMed  Google Scholar 

  9. National Cancer Institute (no date) Surveillance, Epidemiology, and End Results Program (SEER). SEER Stat Fact Sheets: Thyroid Cancer. Available at: http://seer.cancer.gov/statfacts/html/thyro.html.

  10. Thyroid Cancer Statistics. In: http://www.cancer.org/cancer/thyroidcancer/detailedguide/thyroid-cancer-key-statistics. Accessed 20 Oct 2014

  11. Harach HR, Franssila KO, Wasenius VM. Occult papillary carcinoma of the thyroid. A “normal” finding in Finland. A systematic autopsy study. Cancer. 1985;56:531–8.

    Article  CAS  PubMed  Google Scholar 

  12. Sturgeon C. Patients with thyroid cancer are at higher risk of Bankruptcy than patients with other types of cancer, or those without cancer. Clin Thyroidol. 2013;25:150–1.

    Google Scholar 

  13. Mazzaferri EL. Management of low-risk differentiated thyroid cancer. Endocr pract. 2007;13:498–512. doi:10.4158/EP.13.5.498.

    Article  PubMed  Google Scholar 

  14. Hay ID. Management of patients with low-risk papillary thyroid carcinoma. Endocr Pract. 2007;13:521–33. doi:10.4158/EP.13.5.521.

    Article  PubMed  Google Scholar 

  15. Sugitani I, Toda K, Yamada K, et al. Three distinctly different kinds of papillary thyroid microcarcinoma should be recognized: our treatment strategies and outcomes. World J Surg. 2010;34:1222–31. doi:10.1007/s00268-009-0359-x.

    Article  PubMed  Google Scholar 

  16. Ito Y, Miyauchi A, Inoue H, et al. An observational trial for papillary thyroid microcarcinoma in Japanese patients. World J Surg. 2010;34:28–35. doi:10.1007/s00268-009-0303-0.

    Article  PubMed  Google Scholar 

  17. Ito Y, Miyauchi A, Kihara M, et al. Patient age is significantly related to the progression of papillary microcarcinoma of the thyroid under observation. Thyroid. 2014;24:27–34. doi:10.1089/thy.2013.0367.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  18. Lin KD, Lin JD, Huang MJ, et al. Clinical presentations and predictive variables of thyroid microcarcinoma with distant metastasis. Int Surg. 1997;82:378–81.

    CAS  PubMed  Google Scholar 

  19. Lin HW, Bhattacharyya N. Survival impact of treatment options for papillary microcarcinoma of the thyroid. Laryngoscope. 2009;119:1983–7. doi:10.1002/lary.20617.

    Article  PubMed  Google Scholar 

  20. Nikiforov YE, Rowland JM, Bove KE, et al. Distinct pattern of ret oncogene rearrangements in morphological variants of radiation-induced and sporadic thyroid papillary carcinomas in children. Cancer Res. 1997;57:1690–4.

    CAS  PubMed  Google Scholar 

  21. Wada N, Duh Q-Y, Sugino K, et al. Lymph node metastasis from 259 papillary thyroid microcarcinomas. Ann Surg. 2003;237:399–407. doi:10.1097/01.SLA.0000055273.58908.19.

    PubMed Central  PubMed  Google Scholar 

  22. Lee J, Park JH, Lee C-R, et al. Long-term outcomes of total thyroidectomy versus thyroid lobectomy for papillary thyroid microcarcinoma: comparative analysis after propensity score matching. Thyroid. 2013;23:1408–15. doi:10.1089/thy.2012.0463.

    Article  PubMed  Google Scholar 

  23. He Q, Zhuang D, Zheng L, et al. The surgical management of papillary thyroid microcarcinoma: a 162-month single-center experience of 273 cases. Am Surg. 2012;78(11):1215–8.

    PubMed  Google Scholar 

  24. Iyer NG, Morris LGT, Tuttle RM, et al. Rising incidence of second cancers in patients with low-risk (T1N0) thyroid cancer who receive radioactive iodine therapy. Cancer. 2011;117:4439–46. doi:10.1002/cncr.26070.

    Article  PubMed Central  PubMed  Google Scholar 

  25. Lang W, Borrusch H, Bauer L. Occult carcinomas of the thyroid. Evaluation of 1,020 sequential autopsies. Am J Clin Pathol. 1988;90:72–6.

    CAS  PubMed  Google Scholar 

  26. Yamashita H, Noguchi S, Murakami N, et al. Extracapsular invasion of lymph node metastasis. Cancer. 1999;86:842–9. doi:10.1002/(SICI)1097-0142(19990901)86:5<842::AID-CNCR21>3.0.CO;2-X.

    Article  CAS  PubMed  Google Scholar 

  27. Chisholm EJ, Kulinskaya E, Tolley NS. Systematic review and meta-analysis of the adverse effects of thyroidectomy combined with central neck dissection as compared with thyroidectomy alone. Laryngoscope. 2009;119:1135–9. doi:10.1002/lary.20236.

    Article  PubMed  Google Scholar 

  28. Cooper DS, Doherty GM, Haugen BR, et al. (2009) American Thyroid Association (ATA) guidelines taskforce on thyroid nodules and differentiated thyroid cancer. Thyroid. 19(11):1167–214. doi:10.1089/thy.2009.0110.

    Google Scholar 

  29. Noguchi S, Yamashita H, Uchino S, Watanabe S. Papillary microcarcinoma. World J Surg. 2008;32:747–53. doi:10.1007/s00268-007-9453-0.

    Article  PubMed Central  PubMed  Google Scholar 

  30. Pacini F, Castagna MG, Brilli L, et al. Thyroid cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2012;23 Suppl 7:110–9. doi:10.1093/annonc/mds230.

    Article  Google Scholar 

  31. Tuttle M, Ball DW, Byrd D, et al. NCCN clinical practice guidelines in oncology—Thyroid Carcinoma. 2013. NCCN.

    Google Scholar 

  32. Sugitani I, Fujimoto Y. Does postoperative thyrotropin suppression therapy truly decrease recurrence in papillary thyroid carcinoma? A randomized controlled trial. J Clin Endocrinol Metab. 2010;95:4576–83. doi:10.1210/jc.2010-0161.

    Article  CAS  PubMed  Google Scholar 

  33. Klein Hesselink EN, Klein Hesselink MS, de Bock GH, et al. Long-term cardiovascular mortality in patients with differentiated thyroid carcinoma: an observational study. J Clin Oncol. 2013;31:4046–53. doi:10.1200/JCO.2013.49.1043.

    Article  PubMed  Google Scholar 

  34. Pickles T, Ruether JD, Weir L, et al. Psychosocial barriers to active surveillance for the management of early prostate cancer and a strategy for increased acceptance. BJU Int. 2007;100:544–51. doi:10.1111/j.1464-410X.2007.06981.x.

    Article  PubMed  Google Scholar 

  35. Satge D, Grob JC, Pusel J, Methlin G. Thyroid microcarcinoma with a fatal outcome and 34 other unusually aggressive cases reported in the literature. Arch Anat Cytol Pathol. 1990;38:143–51.

    CAS  PubMed  Google Scholar 

  36. Lissak B, Vannetzel JM, Gallouedec N, et al. Solitary skin metastasis as the presenting feature of differentiated thyroid microcarcinoma: report of two cases. J Endocrinol Invest. 1995;18:813–6.

    Article  CAS  PubMed  Google Scholar 

  37. Akazaki K, Kajita A, Higo N. An autopsy case of microscopic sized thyroid carcinoma characterized by generalized bone metastases. Syujyutu. 1960;14:66–71.

    Google Scholar 

  38. Patchefsky AS, Keller IB, Mansfield CM. Solitary vertebral column metastasis from occult sclerosing carcinoma of the thyroid gland: report of a case. Am J Clin Pathol. 1970;53:596–601.

    CAS  PubMed  Google Scholar 

  39. Levi E. Carcinoma of thyroid with metastases to lungs. N Y State J Med. 1975;75:1544–6.

    CAS  PubMed  Google Scholar 

  40. Boehm T, Rothouse L, Wartofsky L. Metastatic occult follicular thyroid carcinoma. JAMA. 1976;235:2420–1.

    Article  CAS  PubMed  Google Scholar 

  41. Jancić-Zguricas M, Janković R. Occult papillary carcinoma of the thyroid gland revealed by cancer pericarditis. Pathol Res Pract. 1986;181:761–6. doi:10.1016/S0344-0338(86)80053-X.

    Article  PubMed  Google Scholar 

  42. Michie HR, O’Bryan-Tear CG, Marsh H, Glazer G. Cerebral metastases from occult papillary carcinoma of the thyroid. Br J Surg. 1987;74:647.

    Article  CAS  PubMed  Google Scholar 

  43. (2013) 83rd Annual Meeting of the American thyroid association short call abstracts. Thyroid 23:A-115–A-121. doi: 10.1089/thy.2013.2310.sc

  44. Anandadas CN, Clarke NW, Davidson SE, et al. Early prostate cancer—which treatment do men prefer and why? BJU Int. 2011;107:1762–8. doi:10.1111/j.1464-410X.2010.09833.x.

    Article  PubMed  Google Scholar 

  45. Holmboe ES, Concato J. Treatment decisions for localized prostate cancer: asking men what’s important. J Gen Intern Med. 2000;15:694–701.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  46. Gorin MA, Soloway CT, Eldefrawy A, Soloway MS. Factors that influence patient enrollment in active surveillance for low-risk prostate cancer. Urology. 2011;77:588–91. doi:10.1016/j.urology.2010.10.039.

    Article  PubMed  Google Scholar 

  47. Oliffe JL, Davison BJ, Pickles T, Mróz L. The self-management of uncertainty among men undertaking active surveillance for low-risk prostate cancer. Qual Health Res. 2009;19:432–43. doi:10.1177/1049732309332692.

    Article  PubMed  Google Scholar 

  48. Ito Y, Tomoda C, Uruno T, et al. Preoperative ultrasonographic examination for lymph node metastasis: usefulness when designing lymph node dissection for papillary microcarcinoma of the thyroid. World J Surg. 2004;28:498–501. doi:10.1007/s00268-004-7192-z.

    Article  PubMed  Google Scholar 

Download references

Disclosures

The authors have no relevant conflicts of interest to disclose.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to R. Michael Tuttle M.D. .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Pace, M.D., Tuttle, R.M. (2016). Optimal Treatment for Papillary Microcarcinoma. In: Hanks, J., Inabnet III, W. (eds) Controversies in Thyroid Surgery. Springer, Cham. https://doi.org/10.1007/978-3-319-20523-6_10

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-20523-6_10

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-20522-9

  • Online ISBN: 978-3-319-20523-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics