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Abstract

This first chapter is devoted to the definition of the environmental problem, in size and depth, resulting from the consumption of psychiatric pharmaceuticals. Classification of pharmaceuticals and overall figures concerning production and consumption are presented, substantiated by national, regional and worldwide examples. The lifecycle of pharmaceuticals is addressed in order to justify the environmental impact expected from the generalized usage of medicines. A global explanation and discussion is presented to clarify the processes through which those molecules reach and accumulate in environment. Particular attention is paid to main groups of psychiatric drugs and their relevant physical-chemical characteristics in terms of environmental impact are listed.

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References

  • Alder AC, Bruchet A, Carballa M, Clara M, Joss A, Löffler D, McArdell CS, Miksch K, Omil F, Tuhkanen T, Ternes TA (2006) Consumption and occurrence. In: Ternes TA, Joss A (eds) Human pharmaceuticals, hormones and fragrances. The challenge of micropollutants in urban water management. IWA Publishing, London, pp 15–45

    Google Scholar 

  • Barnes KK, Kolpin DW, Furlong ET, Zaugg SD, Meyer MT, Barber LB (2008) A national reconnaissance of pharmaceuticals and other organic wastewater contaminants in the United States—I) groundwater. Sci Total Environ 402(2–3):192–200

    Article  CAS  Google Scholar 

  • Calisto V, Esteves VI (2009) Psychiatric pharmaceuticals in the environment. Chemosphere 77(10):1257–1274

    Article  CAS  Google Scholar 

  • Ciccone CD (2007) Pharmacology in rehabilitation. Contemporary perspectives in rehabilitation. F. A. Davis Company, USA

    Google Scholar 

  • Courtheyn D, Le Bizec B, Brambilla G, De Brabander HF, Cobbaert E, Van de Wiele M, Vercammen J, De Wasch K (2002) Recent developments in the use and abuse of growth promoters. Anal Chim Acta 473(1–2):71–82

    Article  CAS  Google Scholar 

  • EEA (2010) Pharmaceuticals in the environment. In: Results of EEA workshop. EEA technical report No 1/2010. Copenhagen

    Google Scholar 

  • Esplugas S, Bila DM, Krause LGT, Dezotti M (2007) Ozonation and advanced oxidation technologies to remove endocrine disrupting chemicals (EDCs) and pharmaceuticals and personal care products (PPCPs) in water effluents. J Hazard Mater 149(3):631–642

    Article  CAS  Google Scholar 

  • Eurobarometer (2010) Mental health part 1: report directorate general health and consumers survey co-ordinated by directorate general, communication

    Google Scholar 

  • Fent K, Weston AA, Caminada D (2006) Ecotoxicology of human pharmaceuticals. Aquat Toxicol 76(2):122–159

    Article  CAS  Google Scholar 

  • Heidler J, Halden RU (2008) Meta-analysis of mass balances examining chemical fate during wastewater treatment. Environ Sci Technol 42(17):6324–6332

    Article  CAS  Google Scholar 

  • Houtman CJ, Kroesbergen J, Lekkerkerker-Teunissen K, van der Hoek JP (2014) Human health risk assessment of the mixture of pharmaceuticals in Dutch drinking water and its sources based on frequent monitoring data. Sci Total Environ 496:54–62

    Article  CAS  Google Scholar 

  • INCB (2009) International narcotics control board, psychotropic substances—statistics for 2007. United Nations, New York

    Google Scholar 

  • INFARMED—Estatística do Medicamento http://www.infarmed.pt/portal/page/portal/INFARMED/MONITORIZACAO_DO_MERCADO/OBSERVATORIO/ESTATISTICA_DO_MEDICAMENTO. Accessed Jan 2015

  • Khetan SK, Collins TJ (2007) Human pharmaceuticals in the aquatic environment: a challenge to green chemistry. Chem Rev 107(6):2319–2364

    Article  CAS  Google Scholar 

  • Kümmerer K (2001) Drugs in the environment: emission of drugs, diagnostic aids and disinfectants into wastewater by hospitals in relation to other sources—a review. Chemosphere 45(6–7):957–969

    Article  Google Scholar 

  • Leonard BE (2010) Classification of psychoactive drugs. Encyclopedia of psychopharmacology. Springer, Heidelberg

    Google Scholar 

  • Loos R, Wollgast J, Huber T, Hanke G (2007) Polar herbicides, pharmaceutical products, perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA), and nonylphenol and its carboxylates and ethoxylates in surface and tap waters around Lake Maggiore in Northern Italy. Anal Bioanal Chem 387(4):1469–1478

    Article  CAS  Google Scholar 

  • Matamoros V, Bayona JM (2006) Elimination of pharmaceuticals and personal care products in subsurface flow constructed wetlands. Environ Sci Technol 40(18):5811–5816

    Article  CAS  Google Scholar 

  • Moldovan Z (2006) Occurrences of pharmaceutical and personal care products as micropollutants in rivers from Romania. Chemosphere 64(11):1808–1817

    Article  CAS  Google Scholar 

  • Monteiro SC, Boxall ABA (2010) Occurrence and fate of human pharmaceuticals in the environment. In: Reviews of environmental contamination and toxicology, vol 202. Reviews of environmental contamination and toxicology. Springer, New York, pp 53–154

    Google Scholar 

  • Moreno-González R, Rodríguez-Mozaz S, Gros M, Pérez-Cánovas E, Barceló D, León VM (2014) Input of pharmaceuticals through coastal surface watercourses into a Mediterranean lagoon (Mar Menor, SE Spain): sources and seasonal variations. Sci Total Environ 490:59–72

    Article  Google Scholar 

  • Nandi A, Beard J, Galea S (2009) Epidemiologic heterogeneity of common mood and anxiety disorders over the lifecourse in the general population: a systematic review. BMC Psychiatry 9(1):31

    Article  Google Scholar 

  • OECD (2014) Health at a glance: Europe 2014

    Google Scholar 

  • Pedrouzo M, Reverté S, Borrull F, Pocurull E, Marcé RM (2007) Pharmaceutical determination in surface and wastewaters using high-performance liquid chromatography-(electrospray)-mass spectrometry. J Sep Sci 30(3):297–303

    Article  CAS  Google Scholar 

  • Sacher F, Lange FT, Brauch H-J, Blankenhorn I (2001) Pharmaceuticals in groundwaters: analytical methods and results of a monitoring program in Baden-Württemberg, Germany. J Chromatogr A 938(1–2):199–210

    Article  CAS  Google Scholar 

  • Sadezky A, Lӧffler D, Schlüsener M, Roig B, Ternes T (2010) Real situation: occurence of the main investigated PPs in water bodies. In: Roig B (ed) Pharmaceuticals in the environment: current knowledge and need assessment to reduce presence and impact. IWA Publishing, London

    Google Scholar 

  • Santos LHMLM, Araújo AN, Fachini A, Pena A, Delerue-Matos C, Montenegro MCBSM (2010) Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment. J Hazard Mater 175(1–3):45–95

    Article  CAS  Google Scholar 

  • Sethi S (2008) Textbook of psychiatry. Elsevier, New Delhi

    Google Scholar 

  • Silva LJG, Lino CM, Meisel LM, Pena A (2012) Selective serotonin re-uptake inhibitors (SSRIs) in the aquatic environment: an ecopharmacovigilance approach. Sci Total Environ 437:185–195

    Article  CAS  Google Scholar 

  • SRC—Interactive PhysProp Database (2011) http://www.srcinc.com/what-we-do/product.aspx?id=133

  • Verlicchi P, Al Aukidy M, Zambello E (2012) Occurrence of pharmaceutical compounds in urban wastewater: removal, mass load and environmental risk after a secondary treatment—a review. Sci Total Environ 429:123–155

    Article  CAS  Google Scholar 

  • Wen Z-H, Chen L, Meng X-Z, Duan Y-P, Zhang Z-S, Zeng EY (2014) Occurrence and human health risk of wastewater–derived pharmaceuticals in a drinking water source for Shanghai, East China. Sci Total Environ 490:987–993

    Article  CAS  Google Scholar 

  • WHO (2011) Pharmaceuticals in drinking-water World Health Organization, Geneva

    Google Scholar 

  • Wu C, Spongberg AL, Witter JD, Fang M, Czajkowski KP (2010) Uptake of pharmaceutical and personal care products by soybean plants from soils applied with biosolids and irrigated with contaminated water. Environ Sci Technol 44(16):6157–6161

    Article  CAS  Google Scholar 

  • Yuan S, Jiang X, Xia X, Zhang H, Zheng S (2013) Detection, occurrence and fate of 22 psychiatric pharmaceuticals in psychiatric hospital and municipal wastewater treatment plants in Beijing, China. Chemosphere 90(10):2520–2525

    Article  CAS  Google Scholar 

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Correspondence to Teresa Tavares .

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Silva, B., Costa, F., Neves, I.C., Tavares, T. (2015). Introduction. In: Psychiatric Pharmaceuticals as Emerging Contaminants in Wastewater. SpringerBriefs in Molecular Science(). Springer, Cham. https://doi.org/10.1007/978-3-319-20493-2_1

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