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Personalization of Atrial Electrophysiology Models from Decapolar Catheter Measurements

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Functional Imaging and Modeling of the Heart (FIMH 2015)

Part of the book series: Lecture Notes in Computer Science ((LNIP,volume 9126))


A novel method to characterize biophysical atria regional ionic models from multi-electrode catheter measurements and tailored pacing protocols is presented. Local atria electrophysiology was described by the Mitchell and Schaeffer 2003 action potential model. The pacing protocol was evaluated using simulated bipolar signals from a decapolar catheter in a model of atrial tissue. The protocol was developed to adhere to the constraints of the clinical stimulator and extract the maximum information about local electro-physiological properties solely from the time the activation wave reaches each electrode. Parameters were fitted by finding the closest parameter set to a data base of 3125 pre computed solutions each with different parameter values. This fitting method was evaluated using 243 randomly generated in silico data sets and yielded a mean error of \(\pm 10.46\,\%\) error in estimating model parameters.

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  1. Kneller, J., Zou, R., Vigmond, E., et al.: Cholinergic atrial fibrillation in a computer model of two-dimensional sheet of canine atrial cells with realistic ionic properties. Circ. Res. 90(9), e73–e87 (2002)

    Article  Google Scholar 

  2. Aslandi, O.V., Colman, M.A., Stott, J., et al.: 3D virtual human atria: a computational platform for studying clinical atrial fibrillation. Prog. Biophys. Mol. Biol. 107(1), 156–168 (2011)

    Article  Google Scholar 

  3. Kistler, P.M., Ho, S.Y., Rajappan, K., et al.: Electrophysiologic and anatomic characterization of sites resistant to electrical isolation during circumferential pulmonary vein ablation for atrial fibrillation: a prospective study. Circ. Res. 90(9), e73–e87 (2002)

    Article  Google Scholar 

  4. Colli Franzone, P., Pavarino, L.F., Savaré, G.: Computational electrocardiology: mathematical and numerical modeling. In: Quarteroni, A., Formaggia, L., Veneziani, A. (eds.) Complex Systems in Biomedicine, pp. 187–241. Springer, Milan (2006)

    Chapter  Google Scholar 

  5. Potse, M., Dubé, B., Richer, J., et al.: A comparison of monodomain and bidomain reaction-diffusion models for action potential propagation in the human heart. IEEE Trans. Biomed. Eng. 53, 2425–2435 (2006)

    Article  Google Scholar 

  6. Tung, L.: A bi-domain model for describing ischemic myocardial D-C potentials. Ph.D. thesis, MIT (1978)

    Google Scholar 

  7. Mitchell, C.C., Schaeffer, D.G.: A two-current model for the dynamics of cardiac membrane. Bull. Math. Bio. 65, 767–793 (2003)

    Article  Google Scholar 

  8. Mukhopadhyay, S., Ray, G.C.: A new interpretation of nonlinear energy operator and its efficacy in spike detection. IEEE Trans. Biomed. Eng. 45(2), 180–187 (1998)

    Article  Google Scholar 

  9. Franz, M.R., Karasik, P.L., Li, C., et al.: Electrical remodeling of the human atrium: similar effects in patients with chronic atrial fibrillation and atrial flutter. JACC 30(7), 1785–1792 (1997)

    Article  Google Scholar 

  10. Weber, F.M., Luik, A., Schilling, C., et al.: Conduction velocity restitution of the human atrium-an efficient measurement protocol for clinical electrophysiological studies. IEEE Trans. Biomed. Eng. 58(9), 2648–2655 (2011)

    Article  Google Scholar 

  11. Relan, J.: Personalised electrophysiological models of ventricular tachycardia for radio frequency ablation therapy planning. Ph.D. Thesis (2012)

    Google Scholar 

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Correspondence to Cesare Corrado .

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© 2015 Springer International Publishing Switzerland

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Corrado, C., Williams, S., Chubb, H., O’Neill, M., Niederer, S.A. (2015). Personalization of Atrial Electrophysiology Models from Decapolar Catheter Measurements. In: van Assen, H., Bovendeerd, P., Delhaas, T. (eds) Functional Imaging and Modeling of the Heart. FIMH 2015. Lecture Notes in Computer Science(), vol 9126. Springer, Cham.

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-20308-9

  • Online ISBN: 978-3-319-20309-6

  • eBook Packages: Computer ScienceComputer Science (R0)

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