Sensitivity Analysis of Diffusion Tensor MRI in Simulated Rat Myocardium
A model of cardiac microstructure and diffusion MRI is presented. The results show a good correspondence between the simulated and experimental measurements. A sensitivity analysis shows that the diffusivity has the greatest effect on both the apparent diffusion coefficient and the fractional anisotropy. The cross-sectional area of the cells is the next most important factor; the aspect ratio of the cell cross-section also affects the fractional anisotropy. Neither the cell length nor the volume fraction of cells has a marked effect.
KeywordsDiffusion MRI Model Rat Heart
This work is supported by a BBSRC grant (BB/I012117/1), an EPSRC grant (EP/J013250/1) and by funding from the British Heart Foundation (BHF) Centre for Research Excellence. JES and PK are BHF Senior Basic Science Research Fellows (FS/11/50/29038; FS/12/17/29532). VG and PK are supported by BHF New Horizon Grant NH/13/30238. PK holds an ERC Advanced Grant (CardioNect). The authors acknowledge a Wellcome Trust Core Award (090532/Z/09/Z).
- 4.Wu, M.T., Tseng, W.Y.I., Su, M.Y.M., Liu, C.P., Chiou, K.R., Wedeen, V.J., Reese, T.G., Yang, C.F.: Diffusion tensor magnetic resonance imaging mapping the fiber architecture remodeling in human myocardium after infarction: Correlation with viability and wall motion. Circulation 114(10), 1036–45 (2006)CrossRefGoogle Scholar
- 15.McAdams, R.M., McPherson, R.J., Dabestani, N.M., Gleason, C.A., Juul, S.E.: Left ventricular hypertrophy is prevalent in sprague-dawley rats. Comp. Med. 60(5), 357–363 (2010)Google Scholar
- 17.Joint research centre: Institute for the protection and security of the citizen (2014). http://ipsc.jrc.ec.europa.eu/?id=756