Revealing Differences in Anatomical Remodelling of the Systemic Right Ventricle

  • Ernesto Zacur
  • James Wong
  • Reza Razavi
  • Tal Geva
  • Gerald Greil
  • Pablo Lamata
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 9126)

Abstract

Cardiac remodelling, which refers to the change of the shape and size of the myocardium, is an adaptive response to developmental, disease and surgical processes. Traditional metrics of length, volume, aspect ratio or wall thickness are used in the clinic and in medical research, but have limited capabilities to describe complex structures such as the shape of cardiac ventricles. In this work we present an example of how computational analysis of cardiac anatomy can reveal more detailed description of developmental and remodelling patterns. The clinical problem is the analysis of the impact of two different surgical palliation techniques for hypoplastic left heart syndrome. Construction of a computational atlas and the statistical description of its variability are performed from the short axis stack of 128 subjects. Results unveil, for the first time in the literature, the differences in remodelling of the systemic right ventricle depending on the surgical palliation technique.

Keywords

Computational anatomy Statistical shape analysis Systemic right ventricle Discriminative analysis 

Notes

Acknowledgements

This study has received funding by the Department of Health through the NIHR comprehensive Biomedical Research Centre award to Guy’s & St Thomas’ NHS Foundation Trust in partnership with King’s College London and King’s College Hospital NHS Foundation Trust, the Centre of Excellence in Medical Engineering (funded by the Wellcome Trust and EPSRC; grant number WT 088641/Z/09/Z) as well as the BHF Centre of Excellence (British Heart Foundation award RE/08/03). PL holds a Sir Henry Dale Fellowship funded jointly by the Wellcome Trust and the Royal Society (grant no. 099973/Z/12/Z).

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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  • Ernesto Zacur
    • 1
  • James Wong
    • 2
  • Reza Razavi
    • 2
  • Tal Geva
    • 3
  • Gerald Greil
    • 2
  • Pablo Lamata
    • 1
  1. 1.Department of Biomedical EngineeringKing’s College LondonLondonUK
  2. 2.Department of Imaging SciencesKing’s College LondonLondonUK
  3. 3.Boston Children’s HospitalHarvard Medical SchoolBostonUSA

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