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Emergency Contraceptives

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Abstract

Emergency contraceptives (ECs) offer a “last chance” to prevent an unintended pregnancy. Half of all pregnancies in the United States are unintended. It is estimated that if the general population had better knowledge and easier access to ECs, their use could dramatically reduce the number of unintended pregnancies in the United States. Currently in the United States, there are four major EC options available: progestin-only levonorgestrel (LNG) EC pills, combination oral contraceptives (COCs), a progesterone receptor modulator (PRM) EC pill [ulipristal acetate], and the insertion of a copper T intrauterine device (IUD).

Keywords

  • Progestin-only levonorgestrel (LNG) EC pills
  • Combination oral contraceptives (COCs)
  • Progesterone receptor modulator (PRM) EC pill
  • Ulipristal acetate
  • Copper T intrauterine device (IUD)

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References

  1. Finer LN, Zolna MR. Unintended pregnancy in the United States: incidence and disparities, 2006. Contraception. 2011;84:478–85.

    PubMed Central  CrossRef  PubMed  Google Scholar 

  2. von Hertzen H, Piaggio G, Ding J, et al. Low dose mifepristone and two regimens of levonorgestrel for emergency contraception: a WHO multicentre randomized trial. Lancet. 2002;360:1803–10.

    CrossRef  Google Scholar 

  3. Glasier AF, Cameron ST, Fine PM, Logan SJ, Casale W, Van Horn J, Sogor L, Blithe DL, Scherrer B, Mathe H, Jaspart A, Ulmann A, Gainer E. Ulipristal acetate versus levonorgestrel for emergency contraception: a randomized on-inferiority trial and meta-analysis. Lancet. 2010;375:555–62.

    CAS  CrossRef  PubMed  Google Scholar 

  4. Mosher WD, Jones J (2010) Use of contraception in the United States: 1982-2008. National Center for Health Statistics. Vital Health Stat. http://www.cdc.gov/NCHS/data/series/sr23/sr23 029.pdf.

  5. Drazen J, Greene M, Wood A. The FDA, politics, and plan B. N Engl J Med. 2004;350:1561–2.

    CAS  CrossRef  PubMed  Google Scholar 

  6. Food and Drug Administration. FDA’s decision regarding plan B: questions and answers. www.fda.gov/cder/drug/infopage/planB/planBQandA.htm. Accessed 10 Mar 2006.

  7. Croxatto HB, Devoto L, Durand M, et al. Mechanism of action of hormonal preparations used for emergency contraception: a review of the literature. Contraception. 2001;63:111–2.

    CAS  CrossRef  PubMed  Google Scholar 

  8. Hapangama D, Glasier AF, Baird DT. The effects of peri-ovulatory administration of levonorgestrel on the menstrual cycle. Contraception. 2001;63:123–9.

    CAS  CrossRef  PubMed  Google Scholar 

  9. Ling WY, Robichaud A, Zayid I, Wrixon W, MacLeod SC. Mode of action of DL-norgestrel and ethinyl estradiol combination in postcoital contraception. Fertil Steril. 1979;32:297–302.

    CAS  PubMed  Google Scholar 

  10. Brache V, Cochon L, Jesam C, Maldonado R, Salvatierra AM, Levy DP, Gainer E, Croxatto HB. Immediate preovulatory administration of 30 mg ulipristal acetate significantly delays follicular rupture. Hum Reprod. 2010;25:2256–63.

    CAS  CrossRef  PubMed  Google Scholar 

  11. Alvarez F, Brache V, Fernandez E, et al. New insights on the mode of action of intrauterine contraceptive devices in women. Fertil Steril. 1988;49:768–73.

    CAS  PubMed  Google Scholar 

  12. Rivera R, Yacobson I, Grimes D. The mechanism of action of hormonal contraceptives and intrauterine contraceptive devices. Am J Obstet Gynecol. 1999;181:1263–9.

    CAS  CrossRef  PubMed  Google Scholar 

  13. Piaggio G, von Hertzen H, Grimes DA, Van Look PF. Timing of emergency contraception with levonorgestrel or the Yuzpe regimen. Task force on postovulatory methods of fertility regulation. Lancet. 1999;353:721.

    CAS  CrossRef  PubMed  Google Scholar 

  14. Trussell J, Ellertson C, von Hertzen H, et al. Estimating the effectiveness of emergency contraceptive pills. Contraception. 2003;67:259–65.

    CrossRef  PubMed  Google Scholar 

  15. Glasier A, Cameron ST, Blithe D, Scherrer B, et al. Can we identify women at risk of pregnancy despite using emergency contraception? Data from randomized trials of ulipristal acetate and levonorgestrel. Contraception. 2011;84:363–7.

    CAS  CrossRef  PubMed  Google Scholar 

  16. Trussell J, Rodriquez G, Ellertson C. Updated estimates of the effectiveness of the Yuzpe regimen of emergency contraception. Contraception. 1999;59:147–51.

    CAS  CrossRef  PubMed  Google Scholar 

  17. Zhou L, Xiao B. Emergency contraception with Multiload Cu-375 SL IUD: a multicenter clinical trial. Contraception. 2001;64:107–12.

    CAS  CrossRef  PubMed  Google Scholar 

  18. Women’s Capital Corporation. Plan B package insert; information for providers and clients. Washington, DC: Women’s Capital Corporation; 1999.

    Google Scholar 

  19. Raymond E, Creinin M, Barnhart K, Lovvorn A, Rountree R, Trussell J. Meclizine for prevention of nausea associated with use of emergency contraceptive pills: a randomized trial. Obstet Gynecol. 2000;95:271–7.

    CAS  CrossRef  PubMed  Google Scholar 

  20. Glasier A, Baird D. The effects of self-administering emergency contraception. N Engl J Med. 1998;339:1–4.

    CAS  CrossRef  PubMed  Google Scholar 

  21. Ellertson C, Ambardekar S, Hedley A, Coyaji K, Trussell J, Blanchard K. Emergency contraception: randomized comparison of advance provision and information only. Obstet Gynecol. 2001;98:570–5.

    CAS  CrossRef  PubMed  Google Scholar 

  22. Stewart FH, Trussell J. Prevention of pregnancy resulting from rape; a neglected preventive health measure. Am J Prevent Med. 2000;19:228–9.

    CAS  CrossRef  Google Scholar 

  23. Task Force on Postovulatory Methods of Fertility Regulation. Randomised controlled trial of levonorgestrel versus the Yuzpe regimen of combined oral contraceptives for emergency contraception. Lancet. 1998;352:428–33.

    CrossRef  Google Scholar 

  24. Cleland K, Raymond E, Trussell J, Cheng L, Haoping Z. Ectopic pregnancy and emergency contraception: a systematic review. Obstet Gynecol. 2010;115:1263–6.

    PubMed Central  CrossRef  PubMed  Google Scholar 

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Correspondence to Melissa F. Natavio MD, MPH .

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Natavio, M.F. (2016). Emergency Contraceptives. In: Shoupe, D., Mishell, Jr., D. (eds) The Handbook of Contraception. Current Clinical Practice. Humana Press, Cham. https://doi.org/10.1007/978-3-319-20185-6_12

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  • DOI: https://doi.org/10.1007/978-3-319-20185-6_12

  • Publisher Name: Humana Press, Cham

  • Print ISBN: 978-3-319-20184-9

  • Online ISBN: 978-3-319-20185-6

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