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Pharmacological Strategies in the Prevention of Migraine in Children

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Pharmacological Management of Headaches

Part of the book series: Headache ((HEAD))

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Abstract

Preventative treatment of migraine is not only based on drugs. A balanced, flexible and individual treatment must include both non-pharmacological methods, such as bio-behavioral strategies as well as pharmacological measures [1].

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References

  1. Brenner M, Lewis D (2008) The treatment of migraine headaches in children and adolescents. J Pediatr Pharmacol Ther 13(1):17–24

    PubMed Central  PubMed  Google Scholar 

  2. O’Brien HL, Kabbouche MA, Kacperski J et al (2015) Treatment of pediatric migraine. Curr Treat Options Neurol 17(1):326

    PubMed  Google Scholar 

  3. Silberstein SD (2000) Practice parameter: evidence-based guidelines for migraine headache (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 55(6):754–762

    Article  CAS  PubMed  Google Scholar 

  4. Evers S, Afra J, Frese A et al (2006) EFNS guideline on the drug treatment of migraine – report of an EFNS task force. Eur J Neurol 13(6):560–572

    Article  CAS  PubMed  Google Scholar 

  5. Lanzi G, Balottin U, Zambrino CA et al (1996) Guidelines and recommendations for the treatment of migraine in paediatric and adolescent patients. Italian Society for the Study of Headache. Funct Neurol 11(5):269–275

    CAS  PubMed  Google Scholar 

  6. El-Chammas K, Keyes J, Thompson N et al (2013) Pharmacologic treatment of pediatric headaches: a meta-analysis. JAMA Pediatr 167(3):250–258

    Article  PubMed  Google Scholar 

  7. Autret A, Valade D, Debiais S (2012) Placebo and other psychological interactions in headache treatment. J Headache Pain 13(3):191–198

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  8. Sorge F, De Simone R, Marano E et al (1988) Flunarizine in prophylaxis of childhood migraine. A double-blind, placebo-controlled, crossover study. Cephalalgia 8(1):1–6

    Article  CAS  PubMed  Google Scholar 

  9. Guidetti V, Moscato D, Ottaviano S et al (1987) Flunarizine and migraine in childhood. An evaluation of endocrine function. Cephalalgia 7(4):263–266

    Article  CAS  PubMed  Google Scholar 

  10. Lewis DW, Winner P (2006) The pharmacological treatment options for pediatric migraine: an evidence-based appraisal. NeuroRx 3(2):181–191

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  11. Oakley CB, Kossoff EH (2014) Migraine and epilepsy in the pediatric population. Curr Pain Headache Rep 18(3):402

    Article  PubMed  Google Scholar 

  12. Winner P, Pearlman EM, Linder SL, Topiramate Pediatric Migraine Study Investigators et al (2005) Topiramate for migraine prevention in children: a randomized, double-blind, placebo-controlled trial. Headache 45(10):1304–1312

    Article  PubMed  Google Scholar 

  13. Lakshmi CV, Singhi P, Malhi P et al (2007) Topiramate in the prophylaxis of pediatric migraine: a double-blind placebo-controlled trial. J Child Neurol 22(7):829–835

    Article  CAS  PubMed  Google Scholar 

  14. Lewis D (2009) Pediatric migraine. Neurol Clin 27:481–501

    Article  PubMed  Google Scholar 

  15. Caruso JM, Brown WD, Exil G et al (2000) The efficacy of divalproex sodium in the prophylactic treatment of children with migraine. Headache 40(8):672–676

    Article  CAS  PubMed  Google Scholar 

  16. Apostol G, Cady RK, Laforet GA et al (2008) Divalproex extended-release in adolescent migraine prophylaxis: results of a randomized, double-blind, placebo-controlled study. Headache 48(7):1012–1025

    Article  PubMed  Google Scholar 

  17. Serdaroglu G, Erhan E, Tekgul H et al (2002) Sodium valproate prophylaxis in childhood migraine. Headache 42(8):819–822

    Article  PubMed  Google Scholar 

  18. Moore KL (1992) Valproate in the treatment of refractory recurrent headaches: a retrospective analysis of 207 patients. Headache Q 3/3:323–325

    Google Scholar 

  19. Pakalnis A, Greenberg G, Drake ME Jr et al (2001) Pediatric migraine prophylaxis with divalproex. J Child Neurol 16(10):731–734

    Article  CAS  PubMed  Google Scholar 

  20. Lewis D, Diamond S, Scott D et al (2004) Prophylactic treatment of pediatric migraine. Headache 44:230–237

    Article  PubMed  Google Scholar 

  21. Hershey AD, Powers SW, Bentti AL et al (2000) Effectiveness of amitriptyline in the prophylactic management of childhood headaches. Headache 40:539–549

    Article  CAS  PubMed  Google Scholar 

  22. Ludvigsson J (1974) Propranolol used in prophylaxis of migraine in children. Acta Neurol 50:109–115

    Article  CAS  Google Scholar 

  23. Damen L, Bruijn JK, Verhagen AP et al (2005) Symptomatic treatment of migraine in children: a systematic review of medication trials. Pediatrics 116(2):e295–e302

    Article  PubMed  Google Scholar 

  24. Lewis D, Ashwal S, Hershey A, Hirtz D, Yonker M, Silberstein S (2004) Practise parameter: pharmacological treatment of migraine headache in children and adolescents: children and adolescents report of the American Academy of Neurology Qualitee Standards Subcommittee and the Practice Committee of the Child Neurology Society. Neurology 63:2215–2224

    Article  CAS  PubMed  Google Scholar 

  25. Goldberg MR, Sciberras D, De Smet M et al (2001) Influence of beta-adrenoceptor antagonists on the pharmacokinetics of rizatriptan, a 5-HT1B/1D agonist: differential effects of propranolol, nadolol and metoprolol. Br J Clin Pharmacol 52(1):69–76

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  26. Gillies D, Sills M, Forsythe I (1986) Pizotifen (Sanomigran) in childhood migraine. A double-blind controlled trial. Eur Neurol 25:32–35

    Article  CAS  PubMed  Google Scholar 

  27. Salmon MA (1985) Pizotifen in the prophylaxis of childhood migraine. Cephalalgia 5(suppl 3):178

    Google Scholar 

  28. Yorns WR Jr, Hardison HH (2013) Mitochondrial dysfunction in migraine. Semin Pediatr Neurol 20(3):188–193

    Article  PubMed  Google Scholar 

  29. Colombo B, Saraceno L, Comi G (2014) Riboflavin and migraine: the bridge over troubled mitochondria. Neurol Sci 35(Suppl 1):141–144

    Article  PubMed  Google Scholar 

  30. Condò M, Posar A, Arbizzani A et al (2009) A Riboflavin prophylaxis in pediatric and adolescent migraine. J Headache Pain 10(5):361–365

    Article  PubMed Central  PubMed  Google Scholar 

  31. MacLennan SC, Wade FM, Forrest KM et al (2008) High-dose riboflavin for migraine prophylaxis in children: a double-blind, randomized, placebo-controlled trial. J Child Neurol 23(11):1300–1304

    Article  PubMed  Google Scholar 

  32. Bruijn J, Duivenvoorden H, Passchier J et al (2010) Medium-dose riboflavin as a prophylactic agent in children with migraine: a preliminary placebo-controlled, randomised, double-blind, cross-over trial. Cephalalgia 30(12):1426–1434

    Article  PubMed  Google Scholar 

  33. Slater SK, Nelson TD, Kabbouche MA et al (2010) A randomized, double-blinded, placebo-controlled, crossover, add on study of coenzyme Q10 in the prevention of pediatric and adolescent migraine. Cephalalgia 31(8):897–905

    Article  Google Scholar 

  34. Hershey AD, Powers SW, Vockell AL et al (2007) Coenzyme Q10 deficiency and response to supplementation in pediatric and adolescent migraine. Headache 47(1):73–80

    Article  PubMed  Google Scholar 

  35. Bigal ME, Rapoport AM, Sheftell FD et al (2002) New migraine preventive options: an update with pathophysiological considerations. Rev Hosp Clin Fac Med Sao Paulo 57(6):293–298

    Article  PubMed  Google Scholar 

  36. Peikert A, Wilimzig C, Kohne-Volland R (1996) Prophylaxis of migraine with oral magnesium: results from a prospective, multicenter, placebo-controlled and double-blind randomized study. Cephalalgia 16:257–263

    Article  CAS  PubMed  Google Scholar 

  37. Pfaffenrath V, Ostreich W, Haase W (1996) Magnesium in the prophylaxis of migraine – a double-blind, placebo- controlled study. Cephalalgia 16:436–440

    Article  CAS  PubMed  Google Scholar 

  38. Dodick DW, Turkel CC, DeGryse RE et al (2010) OnabotulinumtoxinA for treatment of chronic migraine: pooled results from the double-blind, randomized, placebo-controlled phases of the PREEMPT clinical program. Headache 50(6):921–936

    Article  PubMed  Google Scholar 

  39. Silberstein SD, Dodick DW, Aurora SK et al (2014) Per cent of patients with chronic migraine who responded per onabotulinumtoxinA treatment cycle: PREEMPT. J Neurol Neurosurg Psychiatry doi:10.1136

    Google Scholar 

  40. Kabbouche M, O’Brien H, Hershey AD (2012) OnabotulinumtoxinA in pediatric chronic daily headache. Curr Neurol Neurosci Rep 12(2):114–117

    Article  CAS  PubMed  Google Scholar 

  41. Chan VW, McCabe EJ, MacGregor DL (2009) Botox treatment for migraine and chronic daily headache in adolescents. Tossina BotulinicaJ Neurosci Nurs 41(5):235–243

    Article  Google Scholar 

  42. Barbanti P, Egeo G, Aurilia C et al (2014) Treatment of tension-type headache: from old myths to modern concepts. Neurol Sci 35(1 Suppl):17–21

    Article  PubMed  Google Scholar 

  43. Pinchefsky E, Dubrovsky AS, Friedman D et al (2015) Part II-Management of pediatric post-traumatic headaches. Pediatr Neurol 52(3):270–280. doi:10.1016/j.pediatrneurol.2014.10.015

    Article  PubMed  Google Scholar 

  44. May A, Leone M, Afra J et al (2006) EFNS guidelines on the treatment of cluster headache and other trigeminal-autonomic cephalalgias. Eur J Neurol 13(10):1066–1077

    Article  CAS  PubMed  Google Scholar 

  45. Francis GJ, Becker WJ, Pringsheim TM (2010) Acute and preventive pharmacologic treatment of cluster headache. Neurology 75(5):463–473

    Article  PubMed  Google Scholar 

  46. McNabb S, Whitehouse W (1999) Cluster headache-like disorder in childhood. Arch Dis Child 81(6):511–512

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  47. Gallai B, Mazzotta G, Floridi F et al (2003) Cluster headache in childhood and adolescence: one-year prevalence in an out-patient population. J Headache Pain 4:132–137

    Article  PubMed Central  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Pediatric and Child and Adolescent Neuropsychiatry, “Sapienza” University of Rome, Via dei Sabelli 108, 00185, Rome, Italy

    Valentina Baglioni & Vincenzo Guidetti

Authors
  1. Valentina Baglioni
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  2. Vincenzo Guidetti
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Corresponding author

Correspondence to Vincenzo Guidetti .

Editor information

Editors and Affiliations

  1. Department of Neurology, Athens Naval Hospital, Athens, Greece

    Dimos D. Mitsikostas

  2. Department of Neurology, Ghent University Hospital, Ghent, Belgium

    Koen Paemeleire

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Baglioni, V., Guidetti, V. (2016). Pharmacological Strategies in the Prevention of Migraine in Children. In: Mitsikostas, D., Paemeleire, K. (eds) Pharmacological Management of Headaches. Headache. Springer, Cham. https://doi.org/10.1007/978-3-319-19911-5_14

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  • DOI: https://doi.org/10.1007/978-3-319-19911-5_14

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-19910-8

  • Online ISBN: 978-3-319-19911-5

  • eBook Packages: MedicineMedicine (R0)

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