Pharmacokinetics and Pharmacodynamics of Fibrinolytic Agents

  • Carlos Jerjes-SánchezEmail author
  • H. David Rodriguez


In this chapter, the historical development, as well as, pharmacokinetics and pharmacological properties of the more frequently used fibrinolytic agents in pulmonary embolism patients, namely streptokinase, alteplase, and tenecteplase are analyzed. The historical development of the first-, second-, and third-generation fibrinolytics has been reviewed. Also, the first pulmonary embolism case using successful thrombolysis with streptokinase, rt-PA, alteplase, and TNK-t-PA is described.


Fibrinolytic agents Thrombolysis Alteplase Streptokinase Tenecteplase 


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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  1. 1.Instituto de Cardiologia y Medicina Vascular, TEC SaludSan Pedro Garza GarciaMexico
  2. 2.Escuela de Medicina, Tecnológico de MonterreySan Pedro Garza GarciaMexico
  3. 3.Unidad de Investigacion Clinica en Medicina SCMonterreyMexico
  4. 4.Research Studies Coordinator, Centro de Investigacion Basica y Transferencia, Hospital Zambrano-Hellion, Escuela de Medicina y Ciencias de la SaludTecnológico de MonterreyMonterreyMexico

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