Leukocyte Cell-Derived Chemotaxin 2 Amyloidosis (ALECT2)

  • Oana Madalina Mereuta
  • Chris P. Larsen
  • Ahmet DoganEmail author
Part of the Current Clinical Pathology book series (CCPATH)


Leukocyte cell-derived chemotaxin 2 amyloidosis (ALECT2) represents the third most common form of renal amyloidosis and has been recently recognized as a frequent cause of hepatic amyloidosis in the USA. The disease shows a restricted geographical and ethnic distribution, and the amyloid deposition in the kidney and liver commonly presents with characteristic pathological features. Nevertheless, ALECT2 amyloidosis has a relatively indolent clinical course which makes the diagnosis difficult. Therefore, an accurate typing of amyloid deposits is required for the appropriate treatment of these patients. We address in this chapter some aspects regarding the pathogenesis of the disease as well as recent advances in the diagnosis of ALECT2 amyloidosis by immunohistochemistry (IHC) and mass spectrometry (MS)-based proteomic analysis.


Leukocyte cell-derived chemotaxin 2 (LECT2) Renal and hepatic amyloidosis Hispanic Globular amyloid Mass spectrometry (MS) 


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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  • Oana Madalina Mereuta
    • 1
  • Chris P. Larsen
    • 2
  • Ahmet Dogan
    • 3
    Email author
  1. 1.Department of PathologyMemorial Sloan Kettering Cancer CenterNew YorkUSA
  2. 2.NephropathLittle RockUSA
  3. 3.Departments of Pathology and Laboratory MedicineMemorial Sloan Kettering Cancer CenterNew YorkUSA

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