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Cutaneous Amyloidosis

  • Oana Madalina Mereuta
  • Ahmet DoganEmail author
Chapter
Part of the Current Clinical Pathology book series (CCPATH)

Abstract

Skin involvement by amyloid commonly indicates a systemic form of amyloidosis, but a localized process may also occur. The spectrum of primary localized cutaneous amyloidosis (PLCA) includes keratinic primary localized amyloidosis (kPLCA), due to deposition of cytokeratins (CKs) and nodular localized primary cutaneous amyloidosis (NLPCA) which is associated with a local B-cell/plasma cell disorder responsible for the local production of amyloidogenic light chains. The distinction between these two skin-restricted forms of amyloidosis relies on the accurate typing of the amyloid deposits. Immunohistochemistry (IHC) and mass spectrometry-based proteomics are fundamental for diagnostic confirmation and provide valuable information regarding the etiology and clinicopathological features of cutaneous amyloidosis.

Keywords

Skin Pruritus Lichen and macular amyloidosis Nodular localized primary cutaneous amyloidosis Cytokeratins Immunoglobulin 

References

  1. 1.
    Schreml S, Szeimies RM, Vogt T, et al. Cutaneous amyloidoses and systemic amyloidoses with cutaneous involvement. Eur J Dermatol. 2010;20:152–60.PubMedGoogle Scholar
  2. 2.
    Brownstein MH, Helwig EB. The cutaneous amyloidoses. II. systemic forms. Arch Dermatol. 1970;102:20–8.PubMedGoogle Scholar
  3. 3.
    Rubinow A, Cohen AS. Skin involvement in generalized amyloidosis: a study of clinically involved and uninvolved skin in 50 patients with primary and secondary amyloidosis. Ann Intern Med. 1978;88:781–5.PubMedGoogle Scholar
  4. 4.
    Barth WF, Willerson JT, Waldmann TA, et al. Primary amyloidosis. Clinical, immunochemical and immunoglobulin metabolism. studies in fifteen patients. Am J Med. 1969;47:259–73.PubMedGoogle Scholar
  5. 5.
    Fernandez-Flores A. Cutaneous amyloidosis: a concept review. Am J Dermatopathol. 2012;34:1–17.PubMedGoogle Scholar
  6. 6.
    Hoshii Y, Takahashi M, Ishihara T, et al. Immunohistochemical classification of 140 autopsy cases with systemic amyloidosis. Pathol Int. 1994;44:352–8.PubMedGoogle Scholar
  7. 7.
    Strege RJ, Saeger W, Linke RP. Diagnosis and immunohistochemical classification of systemic amyloidoses. Report of 43 cases in an unselected autopsy series. Virchows Arch. 1998;433:19–27.PubMedGoogle Scholar
  8. 8.
    Fujimoto N, Yajima M, Ohnishi Y, et al. Advanced glycation end product-modified beta2-microglobulin is a component of amyloid fibrils of primary localized cutaneous nodular amyloidosis. J Invest Dermatol. 2002;118:479–84.PubMedGoogle Scholar
  9. 9.
    Kaiserling E, Krober S. Lymphatic amyloidosis, a previously unrecognized form of amyloid deposition in generalized amyloidosis. Histopathology. 1994;24:215–21.PubMedGoogle Scholar
  10. 10.
    Harkany T, Garzuly F, Csanaky G, et al. Cutaneous lymphatic amyloid deposits in “Hungarian-type” familial transthyretin amyloidosis: a case report. Br J Dermatol. 2002;146:674–9.PubMedGoogle Scholar
  11. 11.
    Rona G. Primary systemic amyloidosis associated with purpura. Can Med Assoc J. 1961;84:1386–9.PubMedCentralPubMedGoogle Scholar
  12. 12.
    Kyle RA, Bayrd ED. Amyloidosis: review of 236 cases. Medicine (Baltimore). 1975;54:271–99.Google Scholar
  13. 13.
    Levine N. Bluish discoloration of periorbital area. Eyelid purpura and patient’s medical history lead to diagnosis. Geriatrics. 2004;59:20.Google Scholar
  14. 14.
    Lee HJ, Chang SE, Lee MW, et al. Systemic amyloidosis associated with multiple myeloma presenting as periorbital purpura. J Dermatol. 2008;35:371–2.PubMedGoogle Scholar
  15. 15.
    Gamba G, Montani N, Anesi E, et al. Clotting alterations in primary systemic amyloidosis. Haematologica. 2000;85:289–92.PubMedGoogle Scholar
  16. 16.
    Takahashi T, Suzukawa M, Akiyama M, et al. Systemic AL amyloidosis with disseminated intravascular coagulation associated with hyperfibrinolysis. Int J Hematol. 2008;87:371–4.PubMedGoogle Scholar
  17. 17.
    Schmidt CP. Purpuric halos around hemangiomas in systemic amyloidosis. Cutis. 1991;48:141–3.PubMedGoogle Scholar
  18. 18.
    Lee DD, Huang CY, Wong CK. Dermatopathologic findings in 20 cases of systemic amyloidosis. Am J Dermatopathol. 1998;20:438–42.PubMedGoogle Scholar
  19. 19.
    Rigdon RH, Noblin FE. Macroglossia accompanying primary systemic amyloidosis. Ann Otol Rhinol Laryngol. 1949;58:470–8.PubMedGoogle Scholar
  20. 20.
    Wheeler GE, Barrows GH. Alopecia universalis. A manifestation of occult amyloidosis and multiple myeloma. Arch Dermatol. 1981;117:815–6.PubMedGoogle Scholar
  21. 21.
    Hunt SJ, Caserio RJ, Abell E. Primary systemic amyloidosis causing diffuse alopecia by telogen arrest. Arch Dermatol. 1991;127:1067–8.PubMedGoogle Scholar
  22. 22.
    Lutz ME, Pittelkow MR. Progressive generalized alopecia due to systemic amyloidosis. J Am Acad Dermatol. 2002;46:434–6.PubMedGoogle Scholar
  23. 23.
    Yoneda K, Kanoh T, Nomura S, et al. Elastolytic cutaneous lesions in myeloma-associated amyloidosis. Arch Dermatol. 1990;126:657–60.PubMedGoogle Scholar
  24. 24.
    Dicker TJ, Morton J, Williamson RM, et al. Myeloma-associated systemic amyloidosis presenting with acquired digital cutis laxa-like changes. Australas J Dermatol. 2002;43:144–6.PubMedGoogle Scholar
  25. 25.
    Johnson TM, Rapini RP, Hebert AA, et al. Bullous amyloidosis. Cutis. 1989;43:346–52.PubMedGoogle Scholar
  26. 26.
    Robert C, Aractingi S, Prost C, et al. Bullous amyloidosis. Report of 3 cases and review of the literature. Medicine (Baltimore). 1993;72:38–44.Google Scholar
  27. 27.
    Grundmann JU, Bonnekoh B, Gollnick H. Extensive haemorrhagic bullous skin manifestation of systemic AA-amyloidosis associated with IgGlambda-myeloma. Eur J Dermatol. 2000;10:139–42.PubMedGoogle Scholar
  28. 28.
    Stoopler ET, Alawi F, Laudenbach JM, et al. Bullous amyloidosis of the oral cavity: a rare clinical presentation and review. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101:734–40.PubMedGoogle Scholar
  29. 29.
    Wang XD, Shen H, Liu ZH. Diffuse haemorrhagic bullous amyloidosis with multiple myeloma. Clin Exp Dermatol. 2008;33:94–6.PubMedGoogle Scholar
  30. 30.
    Alhaddab M, Srolovitz H, Rosen N. Primary systemic amyloidosis presenting as extensive cutaneous ulceration. J Cutan Med Surg. 2006;10:253–6.PubMedGoogle Scholar
  31. 31.
    Mancuso G, Fanti PA, Berdondini RM. Nail changes as the only skin abnormality in myeloma-associated systemic amyloidosis. Br J Dermatol. 1997;137:471–2.PubMedGoogle Scholar
  32. 32.
    Fujita Y, Tsuji-Abe Y, Sato-Matsumura KC, et al. Nail dystrophy and blisters as sole manifestations in myeloma-associated amyloidosis. J Am Acad Dermatol. 2006;54:712–4.PubMedGoogle Scholar
  33. 33.
    Magy N, Liepnieks JJ, Gil H, et al. A transthyretin mutation (Tyr78Phe) associated with peripheral neuropathy, carpal tunnel syndrome and skin amyloidosis. Amyloid. 2003;10:29–33.PubMedGoogle Scholar
  34. 34.
    Ohnishi A, Yamamoto T, Murai Y, et al. Denervation of eccrine glands in patients with familial amyloidotic polyneuropathy type I. Neurology. 1998;51:714–21.PubMedGoogle Scholar
  35. 35.
    Mochizuki H, Kamakura K, Masaki T, et al. Nodular cutaneous amyloidosis and carpal tunnel syndrome due to the amyloidogenic transthyretin His 114 variant. Amyloid. 2001;8:105–10.PubMedGoogle Scholar
  36. 36.
    Miyata T, Nakano T, Masuzawa M, et al. Beta2-microglobulin-induced cutaneous amyloidosis in a patient with long-term hemodialysis. J Dermatol. 2005;32:410–2.PubMedGoogle Scholar
  37. 37.
    Sato KC, Kumakiri M, Koizumi H, et al. Lichenoid skin lesions as a sign of beta 2-microglobulin-induced amyloidosis in a long-term haemodialysis patient. Br J Dermatol. 1993;128:686–9.PubMedGoogle Scholar
  38. 38.
    Uenotsuchi T, Imafuku S, Nagata M, et al. Cutaneous and lingual papules as a sign of beta 2 microglobulin-derived amyloidosis in a longterm hemodialysis patient. Eur J Dermatol. 2003;13:393–5.PubMedGoogle Scholar
  39. 39.
    Albers SE, Fenske NA, Glass LF, et al. Atypical beta 2-microglobulin amyloidosis following short-term hemodialysis. Am J Dermatopathol. 1994;16:179–84.PubMedGoogle Scholar
  40. 40.
    Sethi D, Hutchison AJ, Cary NR, et al. Macroglossia and amyloidoma of the buttock: evidence of systemic involvement in dialysis amyloid. Nephron. 1990;55:312–5.PubMedGoogle Scholar
  41. 41.
    Fernandez-Alonso J, Rios-Camacho C, Valenzuela-Castano A, et al. Pseudotumoral amyloidosis of beta 2-microglobulin origin in the buttock of a patient receiving long term haemodialysis. J Clin Pathol. 1993;46:771–2.PubMedCentralPubMedGoogle Scholar
  42. 42.
    Tom Y, Htwe M, Chandra R, et al. Bilateral beta 2-microglobulin amyloidomas of the buttocks in a long-term hemodialysis patient. Arch Pathol Lab Med. 1994;118:651–3.PubMedGoogle Scholar
  43. 43.
    Lipner HI, Minkowitz S, Neiderman G, et al. Dialysis-related amyloidosis manifested as masses in the buttocks. South Med J. 1995;88:876–8.PubMedGoogle Scholar
  44. 44.
    Shimizu S, Yasui C, Yasukawa K, et al. Subcutaneous nodules on the buttocks as a manifestation of dialysis-related amyloidosis: a clinicopathological entity? Br J Dermatol. 2003;149:400–4.PubMedGoogle Scholar
  45. 45.
    Kiuru-Enari S, Keski-Oja J, Haltia M. Cutis laxa in hereditary gelsolin amyloidosis. Br J Dermatol. 2005;152:250–7.PubMedGoogle Scholar
  46. 46.
    Benedikz E, Blondal H, Gudmundsson G. Skin deposits in hereditary cystatin C amyloidosis. Virchows Arch A Pathol Anat Histopathol. 1990;417:325–31.PubMedGoogle Scholar
  47. 47.
    Hamidi Asl L, Liepnieks JJ, Hamidi Asl K, et al. Hereditary amyloid cardiomyopathy caused by a variant apolipoprotein A1. Am J Pathol. 1999;154:221–7.PubMedCentralPubMedGoogle Scholar
  48. 48.
    Haas N, Kuster W, Zuberbier T, et al. Muckle-Wells syndrome: clinical and histological skin findings compatible with cold air urticaria in a large kindred. Br J Dermatol. 2004;151:99–104.PubMedGoogle Scholar
  49. 49.
    Claes K, Bammens B, Delforge M, et al. Another devastating complication of the Schnitzler syndrome: AA amyloidosis. Br J Dermatol. 2008;158:182–4.PubMedGoogle Scholar
  50. 50.
    Barzilai A, Langevitz P, Goldberg I, et al. Erysipelas-like erythema of familial Mediterranean fever: clinicopathologic correlation. J Am Acad Dermatol. 2000;42:791–5.PubMedGoogle Scholar
  51. 51.
    Danar DA, Kwan TH, Stern RS, et al. Panniculitis in familial Mediterranean fever. Case report with histopathologic findings. Am J Med. 1987;82:829–32.PubMedGoogle Scholar
  52. 52.
    Alonso R, Cistero-Bahima A, Enrique E, et al. Recurrent urticaria as a rare manifestation of familial Mediterranean fever. J Investig Allergol Clin Immunol. 2002;12:60–1.PubMedGoogle Scholar
  53. 53.
    Krishnamurthy S, Job CK. Secondary amyloidosis in leprosy. Int J Lepr Other Mycobact Dis. 1966;34:155–8.PubMedGoogle Scholar
  54. 54.
    Anders EM, McAdam KP, Anders RF. Cell-mediated immunity in amyloidosis secondary to lepromatous leprosy. Clin Exp Immunol. 1977;27:111–7.PubMedCentralPubMedGoogle Scholar
  55. 55.
    Jayalakshmi P, Looi LM, Lim KJ, et al. Autopsy findings in 35 cases of leprosy in Malaysia. Int J Lepr Other Mycobact Dis. 1987;55:510–4.PubMedGoogle Scholar
  56. 56.
    Anand S, Singh R, Aurora AL, et al. Systemic amyloidosis in psoriasis, lepromatous leprosy & cutaneous tuberculosis. Indian J Dermatol. 1976;21:45–51.PubMedGoogle Scholar
  57. 57.
    Sharma SC, Mortimer G, Kennedy S, et al. Secondary amyloidosis affecting the skin in arthropathic psoriasis. Br J Dermatol. 1983;108:205–10.PubMedGoogle Scholar
  58. 58.
    Powell AM, Albert S, Bhogal B, et al. Discoid lupus erythematosus with secondary amyloidosis. Br J Dermatol. 2005;153:746–9.PubMedGoogle Scholar
  59. 59.
    Yi S, Naito M, Takahashi K, et al. Complicating systemic amyloidosis in dystrophic epidermolysis bullosa, recessive type. Pathology. 1988;20:184–7.PubMedGoogle Scholar
  60. 60.
    Arita K, South AP, Hans-Filho G, et al. Oncostatin M receptor-beta mutations underlie familial primary localized cutaneous amyloidosis. Am J Hum Genet. 2008;82:73–80.PubMedCentralPubMedGoogle Scholar
  61. 61.
    LaChance A, Phelps A, Finch J, et al. Nodular localized primary cutaneous amyloidosis: a bullous variant. Clin Exp Dermatol. 2014;39:344–7.PubMedGoogle Scholar
  62. 62.
    Tanaka A, Arita K, Lai-Cheong JE, et al. New insight into mechanisms of pruritus from molecular studies on familial primary localized amyloidosis. Br J Dermatol. 2009;161:1217–24.PubMedGoogle Scholar
  63. 63.
    Kumakiri M, Hashimoto K. Histogenesis of primary localized cutaneous amyloidosis: sequential change of epidermal keratinocytes to amyloid via filamentous degeneration. J Invest Dermatol. 1979;73:150–62.PubMedGoogle Scholar
  64. 64.
    Kobayashi H, Hashimoto K. Amyloidogenesis in organ-limited cutaneous amyloidosis: an antigenic identity between epidermal keratin and skin amyloid. J Invest Dermatol. 1983;80:66–72.PubMedGoogle Scholar
  65. 65.
    Schepis C, Siragusa M, Gagliardi M, et al. Primary macular amyloidosis: an ultrastructural approach to diagnosis. Ultrastruct Pathol. 1999;23:279–84.PubMedGoogle Scholar
  66. 66.
    Apaydin R, Gurbuz Y, Bayramgurler D, et al. Cytokeratin expression in lichen amyloidosus and macular amyloidosis. J Eur Acad Dermatol Venereol. 2004;18:305–9.PubMedGoogle Scholar
  67. 67.
    Hashimoto K, Brownstein MH. Localized amyloidosis in basal cell epitheliomas. Acta Derm Venerel. 1973;53:331–9.Google Scholar
  68. 68.
    Weedon D, Shand E. Amyloid in basal cell carcinomas. Br J Dermatol. 1979;101:141–6.PubMedGoogle Scholar
  69. 69.
    Looi LM. Localized amyloidosis in basal cell carcinoma. A pathologic study. Cancer. 1983;52:1833–6.PubMedGoogle Scholar
  70. 70.
    Zhuang L, Zhu W. Inflammatory linear verrucose epidermal nevus coexisting with lichen amyloidosus. J Dermatol. 1996;23:415–8.PubMedGoogle Scholar
  71. 71.
    MacDonald DM, Black MM. Secondary localized cutaneous amyloidosis in melanocytic naevi. Br J Dermatol. 1980;103:553–6.PubMedGoogle Scholar
  72. 72.
    Hashimoto K, King Jr LE. Secondary localized cutaneous amyloidosis associated with actinic keratosis. J Invest Dermatol. 1973;61:293–9.PubMedGoogle Scholar
  73. 73.
    Speight EL, Milne DS, Lawrence CM. Secondary localized cutaneous amyloid in Bowen’s disease. Clin Exp Dermatol. 1993;18:286–8.PubMedGoogle Scholar
  74. 74.
    Romero LS, Kantor GR, Levin MW, et al. Localized cutaneous amyloidosis associated with mycosis fungoides. J Am Acad Dermatol. 1997;37:124–7.PubMedGoogle Scholar
  75. 75.
    Azon-Masoliver A. Widespread primary localized cutaneous amyloidosis (macular form) associated with systemic sclerosis. Br J Dermatol. 1995;132:163–5.PubMedGoogle Scholar
  76. 76.
    Yoneyama K, Tochigi N, Oikawa A, et al. Primary localized cutaneous nodular amyloidosis in a patient with Sjögren’s syndrome: a review of the literature. J Dermatol. 2005;32:120–3.PubMedGoogle Scholar
  77. 77.
    Ogiyama Y, Hayashi Y, Kou C, et al. Cutaneous amyloidosis in patients with progressive systemic sclerosis. Cutis. 1996;57:28–32.PubMedGoogle Scholar
  78. 78.
    Orihara T, Yanase S, Furuya T. A case of sclerodermatomyositis with cutaneous amyloidosis. Br J Dermatol. 1985;112:213–9.PubMedGoogle Scholar
  79. 79.
    Fujiwara K, Kono T, Ishii M, et al. Primary localized cutaneous amyloidosis associated with autoimmune cholangitis. Int J Dermatol. 2000;39:768–71.PubMedGoogle Scholar
  80. 80.
    Naldi L, Marchesi L, Locati F, et al. Unusual manifestations of primary cutaneous amyloidosis in association with Raynaud’s phenomenon and livedo reticularis. Clin Exp Dermatol. 1992;17:117–20.PubMedGoogle Scholar
  81. 81.
    Verga U, Fugazzola L, Cambiaghi S, et al. Frequent association between MEN 2A and cutaneous lichen amyloidosis. Clin Endocrinol (Oxf). 2003;59:156–61.Google Scholar
  82. 82.
    Breathnach SM. Amyloid and the amyloidosis of the skin. In: Burns T, Breathnach S, Cox C, Griffiths C, editors. Rook’s textbook of dermatology, vol. 3. Oxford: Blackwell; 2004. p. 57.36–51.Google Scholar
  83. 83.
    Venkataram MN, Bhushnurmath SR, Muirhead DE, et al. Frictional amyloidosis: a study of 10 cases. Australas J Dermatol. 2001;42:176–9.PubMedGoogle Scholar
  84. 84.
    Iwasaki K, Mihara M, Nishiura S, et al. Biphasic amyloidosis arising from friction melanosis. J Dermatol. 1991;18:86–91.PubMedGoogle Scholar
  85. 85.
    Salim T, Shenoi SD, Balachandran C, et al. Lichen amyloidosus: a study of clinical, histopathologic and immunofluorescence findings in 30 cases. Indian J Dermatol Venereol Leprol. 2005;71:166–9.PubMedGoogle Scholar
  86. 86.
    Ramirez-Santos A, Labandiera J, Monteagudo B, et al. Lichen amyloidosus without itching indicates that it is not secondary to chronic scratching. Acta Derm Venereol (Stockh). 2006;86:561–2.Google Scholar
  87. 87.
    Wood AC, Hsu S. Pruritic papules on the shins. Lichen amyloidosis. Postgrad Med. 2000;107:249–50.PubMedGoogle Scholar
  88. 88.
    Jhingan A, Lee JS, Kumarasinghe SP. Lichen amyloidosis in an unusual location. Singapore Med J. 2007;48:E165–7.PubMedGoogle Scholar
  89. 89.
    Wenson SF, Jessup CJ, Johnson MM, et al. Primary cutaneous amyloidosis of the external ear: a clinicopathological and immunohistochemical study of 17 cases. J Cutan Pathol. 2012;39:263–9.PubMedGoogle Scholar
  90. 90.
    Lee DD, Huang JY, Wong CK, et al. Genetic heterogeneity of familial primary cutaneous amyloidosis: lack of evidence for linkage with the chromosome 10 pericentromeric region in Chinese families. J Invest Dermatol. 1996;107:30–3.PubMedGoogle Scholar
  91. 91.
    Lin MW, Lee DD, Lin CH, et al. Suggestive linkage of familial primary cutaneous amyloidosis to a locus on chromosome 1q23. Br J Dermatol. 2005;152:29–36.PubMedGoogle Scholar
  92. 92.
    Lee DD, Lin MW, Chen IC, et al. Genome-wide scan identifies a susceptibility locus for familial primary cutaneous amyloidosis on chromosome 5p13.1–q11.2. Br J Dermatol. 2006;155:1201–8.PubMedGoogle Scholar
  93. 93.
    Saeedi M, Ebrahim-Habibi A, Haghighi A, et al. A novel missense mutation in oncostatin M receptor beta causing primary localized cutaneous amyloidosis. Biomed Res Int. 2014;2014:653724.PubMedCentralPubMedGoogle Scholar
  94. 94.
    Wang WH, Li LF, Huang ES, et al. A new c.1845A→T of oncostatin M receptor-β mutation and slightly enhanced oncostatin M receptor-β expression in a Chinese family with primary localized cutaneous amyloidosis. Eur J Dermatol. 2012;22:29–33.PubMedGoogle Scholar
  95. 95.
    Schreml S, Weber BH, Schroder J, et al. Familial primary localized cutaneous amyloidosis with an oncostatin M receptor-β mutation, Pro694Leu. Clin Exp Dermatol. 2013;38:932–5.PubMedGoogle Scholar
  96. 96.
    Arita K, Abe R, Baba K, et al. A novel OSMR mutation in familial primary localized cutaneous amyloidosis in a Japanese family. J Dermatol Sci. 2009;55:64–5.PubMedGoogle Scholar
  97. 97.
    Heinrich PC, Behrmann I, Haan S, et al. Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochem J. 2003;374:1–20.PubMedCentralPubMedGoogle Scholar
  98. 98.
    Chattopadhyay S, Tracy E, Liang P, et al. Interleukin-31 and oncostatin-M mediate distinct signaling reactions and response patterns in lung epithelial cells. J Biol Chem. 2007;282:3014–26.PubMedGoogle Scholar
  99. 99.
    Moriwaki S, Nishigori C, Horiguchi Y, et al. Amyloidosis cutis dyschromica: DNA repair reduction in the cellular response to UV light. Arch Dermatol. 1992;128:966–70.PubMedGoogle Scholar
  100. 100.
    Garg T, Chander R, Jabeen M, et al. Amyloidosis cutis dyschromica: a rare pigmentary disorder. J Cutan Pathol. 2011;38:823–6.PubMedGoogle Scholar
  101. 101.
    Chang YT, Liu HN, Wang WJ, et al. A study of cytokeratin profiles in localized cutaneous amyloids. Arch Dermatol Res. 2004;296:83–8.PubMedGoogle Scholar
  102. 102.
    Borowicz J, Gillespie M, Miller R. Cutaneous amyloidosis. Skinmed. 2011;9:96–100.PubMedGoogle Scholar
  103. 103.
    Irvine AD, McLean WHI. Human keratin diseases: the increasing spectrum of disease and subtlety of the phenotype-genotype correlation. Br J Dermatol. 1999;140:815–28.PubMedGoogle Scholar
  104. 104.
    Steinert PM. Structure, function, and dynamics of keratin intermediate filaments. J Invest Dermatol. 1993;100:729–34.PubMedGoogle Scholar
  105. 105.
    Borowicz J, Shama L, Miller R. Nodular cutaneous amyloidosis. Skinmed. 2011;9:316–8.PubMedGoogle Scholar
  106. 106.
    Hagari Y, Mihara M, Hagari S. Nodular localized cutaneous amyloidosis: detection of monoclonality of infiltrating plasma cells by polymerase chain reaction. Br J Dermatol. 1996;135:630–3.PubMedGoogle Scholar
  107. 107.
    Hagari Y, Mihara M, Konohana I, et al. Nodular localized cutaneous amyloidosis: further demonstration of monoclonality of infiltrating plasma cells in four additional Japanese patients. Br J Dermatol. 1998;138:652–4.PubMedGoogle Scholar
  108. 108.
    Moon AO, Calamia KT, Walsh JS. Nodular amyloidosis: review and long-term follow-up of 16 cases. Arch Dermatol. 2003;139:1157–9.PubMedGoogle Scholar
  109. 109.
    Santos-Juanes J, Galache C, Curto JR, et al. Nodular primary cutaneous amyloidosis. J Eur Acad Dermatol Venereol. 2004;18:224–6.PubMedGoogle Scholar
  110. 110.
    Evers M, Baron E, Zaim MT, et al. Papules and plaques on the nose. Nodular localized primary cutaneous amyloidosis. Arch Dermatol. 2007;143:535–40.PubMedGoogle Scholar
  111. 111.
    Summers EM, Kendrick CG. Primary localized cutaneous nodular amyloidosis and CREST syndrome: a case report and review of the literature. Cutis. 2008;82:55–9.PubMedGoogle Scholar
  112. 112.
    Brownstein MH, Helwig EB. The cutaneous amyloidoses. I. localized forms. Arch Dermatol. 1970;102:8–19.PubMedGoogle Scholar
  113. 113.
    Woollons A, Black MM. Nodular localized primary cutaneous amyloidosis: a long-term follow-up study. Br J Dermatol. 2001;145:105–9.PubMedGoogle Scholar

Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  1. 1.Department of PathologyMemorial Sloan Kettering Cancer CenterNew YorkUSA
  2. 2.Departments of Pathology and Laboratory MedicineMemorial Sloan Kettering Cancer CenterNew YorkUSA

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