Cutaneous Amyloidosis

  • Oana Madalina Mereuta
  • Ahmet DoganEmail author
Part of the Current Clinical Pathology book series (CCPATH)


Skin involvement by amyloid commonly indicates a systemic form of amyloidosis, but a localized process may also occur. The spectrum of primary localized cutaneous amyloidosis (PLCA) includes keratinic primary localized amyloidosis (kPLCA), due to deposition of cytokeratins (CKs) and nodular localized primary cutaneous amyloidosis (NLPCA) which is associated with a local B-cell/plasma cell disorder responsible for the local production of amyloidogenic light chains. The distinction between these two skin-restricted forms of amyloidosis relies on the accurate typing of the amyloid deposits. Immunohistochemistry (IHC) and mass spectrometry-based proteomics are fundamental for diagnostic confirmation and provide valuable information regarding the etiology and clinicopathological features of cutaneous amyloidosis.


Skin Pruritus Lichen and macular amyloidosis Nodular localized primary cutaneous amyloidosis Cytokeratins Immunoglobulin 


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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  1. 1.Department of PathologyMemorial Sloan Kettering Cancer CenterNew YorkUSA
  2. 2.Departments of Pathology and Laboratory MedicineMemorial Sloan Kettering Cancer CenterNew YorkUSA

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