Abstract
Skin involvement by amyloid commonly indicates a systemic form of amyloidosis, but a localized process may also occur. The spectrum of primary localized cutaneous amyloidosis (PLCA) includes keratinic primary localized amyloidosis (kPLCA), due to deposition of cytokeratins (CKs) and nodular localized primary cutaneous amyloidosis (NLPCA) which is associated with a local B-cell/plasma cell disorder responsible for the local production of amyloidogenic light chains. The distinction between these two skin-restricted forms of amyloidosis relies on the accurate typing of the amyloid deposits. Immunohistochemistry (IHC) and mass spectrometry-based proteomics are fundamental for diagnostic confirmation and provide valuable information regarding the etiology and clinicopathological features of cutaneous amyloidosis.
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Mereuta, O.M., Dogan, A. (2015). Cutaneous Amyloidosis. In: Picken, M., Herrera, G., Dogan, A. (eds) Amyloid and Related Disorders. Current Clinical Pathology. Humana Press, Cham. https://doi.org/10.1007/978-3-319-19294-9_34
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