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Amyloidosis of the Lung

  • Karen L. Grogg
  • Oana Madalina Mereuta
  • Ahmet DoganEmail author
Part of the Current Clinical Pathology book series (CCPATH)

Abstract

Amyloidosis involving the lung may represent a systemic disease or a localized process. Despite the common etiology (i.e., deposition of abnormal immunoglobulin proteins designated as AL type), each condition is characterized by distinct clinicopathological features as well as specific treatment and prognosis. Three main histologic presentations are described: nodular pulmonary amyloidosis (NPA), tracheobronchial amyloidosis, both forms limited to the lung, and diffuse alveolar septal amyloidosis which is commonly associated with systemic disease. Detailed biochemical composition of the amyloid deposits involving the lung obtained by proteomic analysis and correlation with immunohistochemistry (IHC) may provide new insights into pathogenesis of the localized pulmonary amyloidosis. Therefore, we highlight herein that most of the NPA cases show codeposition of heavy and light chain immunoglobulins (AL/AH type) and are associated with a lymphoplasmacytic neoplasm in the spectrum of mucosa-associated lymphoid tissue (MALT) lymphoma.

Keywords

Lung amyloidosis Nodular pulmonary amyloidosis Immunoglobulins light and heavy chains Mucosa-associated lymphoid tissue lymphoma Proteomic analysis 

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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  • Karen L. Grogg
    • 1
  • Oana Madalina Mereuta
    • 2
  • Ahmet Dogan
    • 3
    Email author
  1. 1.Department of Laboratory Medicine and PathologyMayo ClinicRochesterUSA
  2. 2.Department of PathologyMemorial Sloan Kettering Cancer CenterNew YorkUSA
  3. 3.Departments of Pathology and Laboratory MedicineMemorial Sloan Kettering Cancer CenterNew YorkUSA

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