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Amyloidosis of the Lung

  • Chapter
Amyloid and Related Disorders

Part of the book series: Current Clinical Pathology ((CCPATH))

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Abstract

Amyloidosis involving the lung may represent a systemic disease or a localized process. Despite the common etiology (i.e., deposition of abnormal immunoglobulin proteins designated as AL type), each condition is characterized by distinct clinicopathological features as well as specific treatment and prognosis. Three main histologic presentations are described: nodular pulmonary amyloidosis (NPA), tracheobronchial amyloidosis, both forms limited to the lung, and diffuse alveolar septal amyloidosis which is commonly associated with systemic disease. Detailed biochemical composition of the amyloid deposits involving the lung obtained by proteomic analysis and correlation with immunohistochemistry (IHC) may provide new insights into pathogenesis of the localized pulmonary amyloidosis. Therefore, we highlight herein that most of the NPA cases show codeposition of heavy and light chain immunoglobulins (AL/AH type) and are associated with a lymphoplasmacytic neoplasm in the spectrum of mucosa-associated lymphoid tissue (MALT) lymphoma.

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Author information

Authors and Affiliations

  1. Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA

    Karen L. Grogg MD

  2. Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA

    Oana Madalina Mereuta MD, PhD

  3. Departments of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA

    Ahmet Dogan MD, PhD

Authors
  1. Karen L. Grogg MD
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  2. Oana Madalina Mereuta MD, PhD
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  3. Ahmet Dogan MD, PhD
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Corresponding author

Correspondence to Ahmet Dogan MD, PhD .

Editor information

Editors and Affiliations

  1. Department of Pathology, Loyola University Medical Center, Maywood, Illinois, USA

    Maria M. Picken

  2. Department of Pathology, LSU Health Shreveport, Shreveport, Louisiana, USA

    Guillermo A. Herrera

  3. Department of Pathology and Laboratory Medicine, Department of Pathology and Laboratory Medicine, New York, New York, USA

    Ahmet Dogan

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Grogg, K.L., Mereuta, O.M., Dogan, A. (2015). Amyloidosis of the Lung. In: Picken, M., Herrera, G., Dogan, A. (eds) Amyloid and Related Disorders. Current Clinical Pathology. Humana Press, Cham. https://doi.org/10.1007/978-3-319-19294-9_33

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  • DOI: https://doi.org/10.1007/978-3-319-19294-9_33

  • Publisher Name: Humana Press, Cham

  • Print ISBN: 978-3-319-19293-2

  • Online ISBN: 978-3-319-19294-9

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