Amyloidosis of the Lymph Nodes and the Spleen

  • Filiz Sen
  • Ahmet DoganEmail author
Part of the Current Clinical Pathology book series (CCPATH)


Lymph node and spleen involvement is frequent in systemic amyloidosis. AL amyloidosis is the most common and clinically most important cause of lymph node amyloidosis. In most cases, the lymph node AL amyloidosis is systemic and caused by an underlying systemic plasma cell or B-cell neoplasm. For this reason, immunophenotypic analysis of the lymphoid component is required in these cases for management decisions. Other etiologies of lymph node amyloidosis include AA amyloidosis and rarely hereditary amyloidoses such as AAPOA1 or ATTR amyloidosis. By imaging studies, the spleen is involved in most cases of systemic AL and AA amyloidosis. Clinically splenic involvement may lead to hyposplenism, and occasionally, splenic rupture. In addition to AL and AA, amyloidosis and other systemic amyloidoses such as ALECT2 amyloidosis can also affect the spleen.


Amyloidosis Lymph node Spleen Plasma cell neoplasms Myeloma Lymphoplasmacytic lymphoma LECT2 AA SAA 


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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  1. 1.Department of PathologyMemorial Sloan Kettering Cancer CenterNew YorkUSA
  2. 2.Departments of Pathology and Laboratory MedicineMemorial Sloan Kettering Cancer CenterNew YorkUSA

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