Amyloid Typing: Experience from a Large Referral Centre
Amyloidosis is caused by the deposition in tissues of abnormal protein in a characteristic fibrillar form. There are many types of amyloidoses, which are classified according to the soluble protein precursor from which the amyloid fibrils are derived. Accurate identification of amyloid type is critical in every case since therapy for systemic amyloidosis is type-specific. Here we present experience from the UK National Amyloidosis Centre (NAC) histopathological service highlighting some of the important difficulties encountered and limitations of the available techniques for amyloid typing.
KeywordsBiopsies Congo red Immunohistochemistry Proteomics Laser capture microdissection and mass spectrometry NAC Amyloid
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