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The Skeletal System

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Keeling’s Fetal and Neonatal Pathology

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Abstract

Skeletal dysplasias are a group of disorders with a disturbance in development and/or growth of cartilage and/or bone. Epiphysis, metaphysis, and diaphysis of long bones are affected in a generalized manner with or without involvement of membranous bone of the skull. A dysostosis affects one or some skeletal elements, while the other bones remain normal. There are approximately 450 different disorders known with involvement of the skeleton. Some 50 dysplasias are lethal. Lethality is usually based on thoracic underdevelopment and lung hypoplasia. The overall frequency among stillbirths and liveborns has been estimated to be 1 per 4000 to 1 per 6000 births and the frequency among perinatal deaths to be 1 per 110 deaths.

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Authors and Affiliations

  1. Department of Pathology, University Hospital Utrecht, Utrecht, The Netherlands

    Peter G. J. Nikkels MD, PhD

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  1. Peter G. J. Nikkels MD, PhD
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Correspondence to Peter G. J. Nikkels MD, PhD .

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Editors and Affiliations

  1. Department of Pathology Department of Obstetrics and Gynaecology, University of Adelaide, North Adelaide, South Australia, Australia

    T. Yee Khong

  2. Department of Histopathology, Women’s & Children’s Hospital, North Adelaide, South Australia, Australia

    T. Yee Khong

  3. Department of Histopathology, University Hospitals of Leicester NHS Trust Leicester Royal Infirmary, Leicester, UK

    Roger D. G. Malcomson

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Nikkels, P.G.J. (2015). The Skeletal System. In: Khong, T.Y., Malcomson, R.D.G. (eds) Keeling’s Fetal and Neonatal Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-19207-9_31

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  • DOI: https://doi.org/10.1007/978-3-319-19207-9_31

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-19206-2

  • Online ISBN: 978-3-319-19207-9

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