Acquired Diseases of the Nervous System

  • Colin SmithEmail author
  • Thomas S. Jacques


Acquired disorders of the nervous system are responsible for considerable perinatal mortality and for devastating chronic handicap in children, usually manifesting as cerebral palsy. Data from the Centers for Disease Control and Prevention (CDC) suggest a prevalence of cerebral palsy of between 1.5 and more than 4 per 1000 live births ( Identification of acquired lesions and their distinction from genetic disorders can be difficult because damage to the fetal brain disrupts the normal sequence of development and can lead to malformations. Furthermore, a number of genetic disorders can cause destructive lesions in the fetal and perinatal brain that resemble acquired insults. This chapter describes the more common acquired conditions likely to be encountered in routine postmortem examinations of neonates and fetuses.


Brain Spinal cord Fetus Neonate Pathological reaction Injury Trauma Intracranial hemorrhage Subdural hemorrhage Hypoxia Ischemia Infection Metabolic disorder 


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Copyright information

© Springer International Publishing 2015

Authors and Affiliations

  1. 1.Department of Academic Neuropathology, Centre for Clinical Brain SciencesUniversity of EdinburghEdinburgh, MidlothianUK
  2. 2.Developmental Biology and Cancer Programme and Department of HistopathologyUCL Institute of Child Health and Great Ormond Street HospitalLondonUK

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