The Reticuloendothelial System

  • T. Yee KhongEmail author


The development of the spleen and the thymus is described. Developmental abnormalities of the spleen include polyasplenia, a term that encompasses the spectrum of disorders of asplenia and polysplenia. Splenogonadal fusion and splenopancreatic fusion are two uncommon anomalies that are associated with other anomalies. Developmental abnormalities of the thymus include ectopia, aplasia, and hypoplasia, the last two of which may be related to DiGeorge syndrome, itself mainly due to deletion of chromosome 22q11. Intrauterine stress leads to involution of the thymus.


Spleen Thymus Polyasplenia Asplenia Polysplenia Thymus aplasia DiGeorge syndrome 22q11.2 deletion syndrome 


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Copyright information

© Springer International Publishing 2015

Authors and Affiliations

  1. 1.Department of Pathology and Department of Obstetrics and GynaecologyUniversity of AdelaideNorth AdelaideAustralia
  2. 2.Department of HistopathologyWomen’s & Children’s HospitalNorth AdelaideAustralia

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