Congenital Tumors

  • Adrian K. CharlesEmail author


Congenital tumors are rare and intriguing, and they are challenging, diagnostically, scientifically, therapeutically, and sometimes ethically. For many years, since at least when Willis wrote a book on the subject, there has been study of The Borderline of Embryology and Pathology. Congenital tumors certainly fit this space and this is reflected in their appearances and more in their molecular biology. They probably have a lot more to teach us.

There has not been the time for multiple mutations to develop as for adult tumors. These tumors are often genomically and chromosomally similar to the host, and morphologically they often appear to recapitulate differentiation. The genetic revolution has taken us further into understanding this close association, showing important pathways in cellular differentiation genes, imprinting, chromatin remodeling, and noncoding RNA. This may explain the issues related to whether these are tumors, or maldevelopment, or both sharing similar largely epigenetic pathways.

This chapter is a review of the major tumor types with some discussion of new entities and some of the pathogenetic factors. There are too many tumors and too many new discoveries to cover all the entities in detail, but this is to give a general guide to the topic.


Neonatal tumors Congenital Neoplasia Oncogenesis Inherited tumors Inherited syndromes Teratogenesis 


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© Springer International Publishing 2015

Authors and Affiliations

  1. 1.Department of PathologySidra Medical and Research Center & Weill Cornell Medical College in QatarDohaQatar

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