Abstract
The perinatal postmortem examination is one investigation offered to parents after they experience the death of their child. From both the parents’ and clinicians’ perspective, the postmortem examination aims to determine what was or was not the cause of death and to identify any relevant associated factors. For parents, appropriate explanation of these findings can facilitate the process of grieving and aid in planning future pregnancies. For professionals, in addition to information for the parents, these data can provide population-level information about why babies die, which are key components of audit and ensuring safety of care. Despite these benefits the rate of perinatal postmortem examination is decreasing in many settings. We review the evidence for perinatal postmortem (and associated) examination in cases of stillbirth and neonatal deaths. We consider the consent process and feedback of information to parents and how this affects whether parents give consent for a postmortem examination. Finally, we consider what the likely developments in perinatal postmortem examination may be and how these will affect clinicians and parents.
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References
Cousens S, Blencowe H, Stanton C, Chou D, Ahmed S, Steinhardt L, et al. National, regional, and worldwide estimates of stillbirth rates in 2009 with trends since 1995: a systematic analysis. Lancet. 2011;377:1319–30.
UNICEF, World Health Organization, The World Bank, United Nations. Levels and trends in child mortality report: 2013. New York: UNICEF; 2013.
Flenady V, Middleton P, Smith GC, Duke W, Erwich JJ, Khong TY, et al. Stillbirths: the way forward in high-income countries. Lancet. 2011;377:1703–17.
Bhutta ZA, Das JK, Bahl R, Lawn JE, Salam RA, Paul VK, et al. Can available interventions end preventable deaths in mothers, newborn babies, and stillbirths, and at what cost? Lancet. 2014;384:347–70.
Alderliesten ME, Stronks K, Bonsel GJ, Smit BJ, van Campen MM, van Lith JM, et al. Design and evaluation of a regional perinatal audit. Eur J Obstet Gynecol Reprod Biol. 2008;137:141–5.
Dahl LB, Berge LN, Dramsdahl H, Vermeer A, Huurnink A, Kaaresen PI, et al. Antenatal, neonatal and post neonatal deaths evaluated by medical audit. A population-based study in northern Norway – 1976 to 1997. Acta Obstet Gynecol Scand. 2000;79:1075–82.
Pattinson R, Kerber K, Waiswa P, Day LT, Mussell F, Asiruddin SK, et al. Perinatal mortality audit: counting, accountability, and overcoming challenges in scaling up in low- and middle-income countries. Int J Gynaecol Obstet. 2009;107:S113–21, S121–112.
Belizan M, Bergh AM, Cilliers C, Pattinson RC, Voce A. Stages of change: a qualitative study on the implementation of a perinatal audit programme in South Africa. BMC Health Serv Res. 2011;11:243.
Pattinson RC, Bergh AM. Implementing recommendations arising from confidential enquiries into maternal deaths. Best Pract Res. 2008;22:477–87.
Royal College of Obstetricians and Gynaecologists. Green-top guideline 55 – late intrauterine fetal death and stillbirth. London: Royal College of Obstetricians and Gynaecologists; 2010.
American College of Obstetricians and Gynecologists. ACOG practice bulletin no. 102: management of stillbirth. Obstet Gynecol. 2009;113:748–61.
Flenady V, King J, Charles A, Gardener G, Ellwood D, Day K, et al. PSANZ clinical practice guideline for perinatal mortality. Version 2.22009.
Heinonen S, Kirkinen P. Pregnancy outcome after previous stillbirth resulting from causes other than maternal conditions and fetal abnormalities. Birth. 2000;27:33–7.
Reddy UM. Prediction and prevention of recurrent stillbirth. Obstet Gynecol. 2007;110:1151–64.
Rankin J, Wright C, Lind T. Cross sectional survey of parents’ experience and views of the postmortem examination. BMJ. 2002;324:816–8.
Heazell A, McLaughlin MJ, Schmidt E, Cox P, Flenady V, Khong T, et al. A difficult conversation? The views and experiences of parents and professionals on the consent process for perinatal postmortem after stillbirth. BJOG. 2012;119:987–97.
Stock SJ, Goldsmith L, Evans MJ, Laing IA. Interventions to improve rates of post-mortem examination after stillbirth. Eur J Obstet Gynecol Reprod Biol. 2010;153:148–50.
Ptacek I, Sebire NJ, Man JA, Brownbill P, Heazell AE. Systematic review of placental pathology reported in association with stillbirth. Placenta. 2014;35:552–62.
Faye-Petersen OM, Guinn DA, Wenstrom KD. Value of perinatal autopsy. Obstet Gynecol. 1999;94:915–20.
Kock KF, Vestergaard V, Hardt-Madsen M, Garne E. Declining autopsy rates in stillbirths and infant deaths: results from Funen County, Denmark, 1986–96. J Matern Fetal Neonatal Med. 2003;13:403–7.
Cartlidge PH, Dawson AT, Stewart JH, Vujanic GM. Value and quality of perinatal and infant postmortem examinations: cohort analysis of 400 consecutive deaths. BMJ. 1995;310:155–8.
Cernach MC, Patricio FR, Galera MF, Moron AF, Brunoni D. Evaluation of a protocol for postmortem examination of stillbirths and neonatal deaths with congenital anomalies. Pediatr Dev Pathol. 2004;7:335–41.
Saller Jr DN, Lesser KB, Harrel U, Rogers BB, Oyer CE. The clinical utility of the perinatal autopsy. JAMA. 1995;273:663–5.
Gordijn SJ, Erwich JJ, Khong TY. Value of the perinatal autopsy: critique. Pediatr Dev Pathol. 2002;5:480–8.
Rodriguez MM, Chaves F, Romaguera RL, Ferrer PL, de la Guardia C, Bruce JH. Value of autopsy in nonimmune hydrops fetalis: series of 51 stillborn fetuses. Pediatr Dev Pathol. 2002;5:365–74.
Alderliesten ME, Peringa J, van der Hulst VP, Blaauwgeers HL, van Lith JM. Perinatal mortality: clinical value of postmortem magnetic resonance imaging compared with autopsy in routine obstetric practice. BJOG. 2003;110:378–82.
Peres LC. Review of pediatric autopsies performed at a university hospital in Ribeirao Preto, Brazil. Arch Pathol Lab Med. 2006;130:62–8.
Hefler LA, Hersh DR, Moore PJ, Gregg AR. Clinical value of postnatal autopsy and genetics consultation in fetal death. Am J Med Genet. 2001;104:165–8.
Hickey L, Murphy A, Devaney D, Gillan J, Clarke T. The value of neonatal autopsy. Neonatology. 2012;101:68–73.
Elder DE, Zuccollo JM. Autopsy after death due to extreme prematurity. Arch Dis Child Fetal Neonatal Ed. 2005;90:F270–2.
Becher JC, Bell JE, Keeling JW, McIntosh N, Wyatt B. The Scottish perinatal neuropathology study: clinicopathological correlation in early neonatal deaths. Arch Dis Child Fetal Neonatal Ed. 2004;89:F399–407.
Elder DE, Zuccollo JM, Stanley TV. Neonatal death after hypoxic ischaemic encephalopathy: does a postmortem add to the final diagnoses? BJOG. 2005;112:935–40.
Boyd PA, Tondi F, Hicks NR, Chamberlain PF. Autopsy after termination of pregnancy for fetal anomaly: retrospective cohort study. BMJ. 2014;328:137.
Rodriguez MA, Prats P, Rodriguez I, Cusi V, Comas C. Concordance between prenatal ultrasound and autopsy findings in a tertiary center. Prenat Diagn. 2014;34:784–9.
Johns N, Al-Salti W, Cox P, Kilby MD. A comparative study of prenatal ultrasound findings and post-mortem examination in a tertiary referral centre. Prenat Diagn. 2004;24:339–46.
Kumari N, Pradhan M, Shankar VH, Krishnani N, Phadke SR. Post-mortem examination of prenatally diagnosed fatal renal malformation. J Perinatol. 2008;28:736–42.
Hayati AR, Khong TY, Zainul R. The usefulness of limited placental sampling in stillbirths. Malays J Pathol. 1998;20:99–102.
Horn LC, Langner A, Stiehl P, Wittekind C, Faber R. Identification of the causes of intrauterine death during 310 consecutive autopsies. Eur J Obstet Gynecol Reprod Biol. 2004;113:134–8.
Heazell AE, Martindale EA. Can post-mortem examination of the placenta help determine the cause of stillbirth? J Obstet Gynaecol. 2009;29:225–8.
Rayburn W, Sander C, Barr Jr M, Rygiel R. The stillborn fetus: placental histologic examination in determining a cause. Obstet Gynecol. 1985;65:637–41.
Tellefsen CH, Vogt C. How important is placental examination in cases of perinatal deaths? Pediatr Dev Pathol. 2011;14:99–104.
Ogunyemi D, Jackson U, Buyske S, Risk A. Clinical and pathologic correlates of stillbirths in a single institution. Acta Obstet Gynecol Scand. 1998;77:722–8.
Incerpi MH, Miller DA, Samadi R, Settlage RH, Goodwin TM. Stillbirth evaluation: what tests are needed? Am J Obstet Gynecol. 1998;178:1121–5.
VanderWielen B, Zaleski C, Cold C, McPherson E. Wisconsin stillbirth services program: a multifocal approach to stillbirth analysis. Am J Med Genet. 2011;155A:1073–80.
Bonetti LR, Ferrari P, Trani N, Maccio L, Laura S, Giuliana S, et al. The role of fetal autopsy and placental examination in the causes of fetal death: a retrospective study of 132 cases of stillbirths. Arch Gynecol Obstet. 2011;283:231–41.
Heazell AEP, Byrd LM, Cockerill R, Whitworth MK. Investigations following stillbirth – which tests are most valuable? Arch Dis Child Fetal Neonatal Ed. 2011;96:Fa135.
Vergani P, Cozzolino S, Pozzi E, Cuttin MS, Greco M, Ornaghi S, et al. Identifying the causes of stillbirth: a comparison of four classification systems. Am J Obstet Gynaecol. 2008;199:319.e311–4.
Flenady V, Froen JF, Pinar H, Torabi R, Saastad E, Guyon G, et al. An evaluation of classification systems for stillbirth. BMC Pregnancy Childbirth. 2009;9:24.
Michalski ST, Porter J, Pauli RM. Costs and consequences of comprehensive stillbirth assessment. Am J Obstet Gynecol. 2002;186:1027–34.
Gold KJ, Sen A, Xu X. Hospital costs associated with stillbirth delivery. Matern Child Health J. 2013;17:1835–41.
Mistry H, Heazell AE, Vincent O, Roberts T. A structured review and exploration of the healthcare costs associated with stillbirth and a subsequent pregnancy in England and Wales. BMC Pregnancy Childbirth. 2013;13:236.
Royal College of Obstetricians and Gynaecologists, Royal College of Pathologists. Joint working party report on fetal and perinatal pathology. London; 1988.
Royal College of Obstetricians and Gynaecologists, Royal College of Pathologists. Fetal and perinatal pathology: report of a joint working party. London; 2001.
Khong TY. A review of perinatal autopsy rates worldwide, 1960s to 1990s. Paediatr Perinat Epidemiol. 1996;10:97–105; discussion 106–9.
Omoniyi-Esan GO, Omonisi AE, Bakare B, Kuti O, Adejuyigbe E. Perinatal autopsies in a tertiary health facility in southwestern Nigeria: a retrospective evaluation of 14 consecutive cases. Niger J Med. 2014;23:153–6.
Confidential enquiry into maternal and child health. Perinatal mortality 2008: England, Wales and northern Ireland. London: Centre for Enquiries into Maternal and Child Health; 2010.
Bishop KL, Dupuis C, Nanton P, Clarke K, Bolt C, Chin-See C. Perinatal autopsy rates at the university hospital of the West Indies: 2002–2008. West Indian Med J. 2013;62:35–8.
Swinton CH, Weiner J, Okah FA. The neonatal autopsy: can it be revived? Am J Perinatol. 2013;30:739–44.
Confidential enquiry into maternal and child health. Perinatal mortality 2009: England, Wales and northern Ireland. London: Centre for Enquiries into Maternal and Child Health; 2011.
Holste C, Pilo C, Pettersson K, Radestad I, Papadogiannakis N. Mothers’ attitudes towards perinatal autopsy after stillbirth. Acta Obstet Gynecol Scand. 2011;90:1287–90.
Breeze AC, Statham H, Hackett GA, Jessop FA, Lees CC. Perinatal postmortems: what is important to parents and how do they decide? Birth. 2012;39:57–64.
Meaney S, Gallagher S, Lutomski JE, O’Donoghue K. Parental decision making around perinatal autopsy: a qualitative investigation. Health Expect. 2014. DOI: 10.1111/hex.12305
Downe S, Kingdon C, Kennedy R, Norwell H, McLaughlin MJ, Heazell AE. Post-mortem examination after stillbirth: views of uk-based practitioners. Eur J Obstet Gynecol Reprod Biol. 2012;162:33–7.
Horey D, Flenady V, Heazell AE, Khong TY. Interventions for supporting parents’ decisions about autopsy after stillbirth. Cochrane Database Syst Rev (Online). 2013;(2):CD009932.
Downe S, Schmidt E, Kingdon C, Heazell AE. Bereaved parents’ experience of stillbirth in uk hospitals: a qualitative interview study. BMJ Open. 2013;3:e002237.
Rose C, Evans M, Tooley J. Falling rates of perinatal postmortem examination: are we to blame? Arch Dis Child Fetal Neonatal Ed. 2006;91:F465.
Henley A, Schott J. The sands audit tool for maternity services – caring for parents whose baby has died. London: Sands – Stillbirth and Neonatal Death Charity; 2011.
Sebire NJ, Weber MA, Thayyil S, Mushtaq I, Taylor A, Chitty LS. Minimally invasive perinatal autopsies using magnetic resonance imaging and endoscopic postmortem examination (“keyhole autopsy”): feasibility and initial experience. J Matern Fetal Neonatal Med. 2012;25:513–8.
Cohen MC, Paley MN, Griffiths PD, Whitby EH. Less invasive autopsy: benefits and limitations of the use of magnetic resonance imaging in the perinatal postmortem. Pediatr Dev Pathol. 2008;11:1–9.
Taylor AM, Sebire NJ, Ashworth MT, Schievano S, Scott RJ, Wade A, et al. Postmortem cardiovascular magnetic resonance imaging in fetuses and children: a masked comparison study with conventional autopsy. Circulation. 2014;129:1937–44.
Thayyil S, Sebire NJ, Chitty LS, Wade A, Chong W, Olsen O, et al. Post-mortem mri versus conventional autopsy in fetuses and children: a prospective validation study. Lancet. 2013;382:223–33.
Ben-Sasi K, Chitty LS, Franck LS, Thayyil S, Judge-Kronis L, Taylor AM, et al. Acceptability of a minimally invasive perinatal/paediatric autopsy: healthcare professionals’ views and implications for practice. Prenat Diagn. 2013;33:307–12.
Reddy UM, Page GP, Saade GR, Silver RM, Thorsten VR, Parker CB, et al. Karyotype versus microarray testing for genetic abnormalities after stillbirth. N Engl J Med. 2012;367:2185–93.
Harris RA, Ferrari F, Ben-Shachar S, Wang X, Saade G, Van Den Veyver I, et al. Genome-wide array-based copy number profiling in human placentas from unexplained stillbirths. Prenat Diagn. 2011;31:932–44.
Crotti L, Tester DJ, White WM, Bartos DC, Insolia R, Besana A, et al. Long qt syndrome-associated mutations in intrauterine fetal death. JAMA. 2013;309:1473–82.
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Heazell, A., Fenton, A. (2015). The Perinatal Postmortem from a Clinician’s Viewpoint. In: Khong, T.Y., Malcomson, R.D.G. (eds) Keeling’s Fetal and Neonatal Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-19207-9_1
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DOI: https://doi.org/10.1007/978-3-319-19207-9_1
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