• Danya Reich
  • Corinna Eleni Psomadakis
  • Bobby Buka


Vitiligo is a cutaneous disorder of depigmentation that occurs due to autoimmune destruction of the skin’s pigment-producing melanocytes. The exact cause is unknown and thought to be influenced by multiple genes and environment factors. Vitiligo is characterized by chalk-white macules that show uniform loss of pigment of the affected skin and hair (leukotrichia). There is an association between vitiligo and other autoimmune disorders, such as diabetes, Addison’s disease, and autoimmune thyroiditis. Treatment of vitiligo concentrates on modifying the body’s immune response. This is achieved primarily with topical corticosteroids, vitamin D analogues, calcineurin inhibitors, and phototherapy.


Vitiligo Idiopathic Depigmentation Hypopigmentation Generalized Segmental Non-segmental Autoimmune Diabetes Addison’s disease Hypothyroid Hyperthyroid Macules Leukotrichia Repigmentation Phototherapy Vitamin D analogues Calcipotriene Calcineurin inhibitors Topical corticosteroids Melanin Ultraviolet light 


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© Springer International Publishing Switzerland 2017

Open Access This chapter is distributed under the terms of the Creative Commons Attribution Noncommercial License, which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.

Authors and Affiliations

  • Danya Reich
    • 1
  • Corinna Eleni Psomadakis
    • 2
  • Bobby Buka
    • 3
  1. 1.Department of Family MedicineMount Sinai School of Medicine Attending Mount Sinai Doctors/Beth Israel Medical Group-WilliamsburgBrooklynUSA
  2. 2.School of Medicine Imperial College LondonLondonUK
  3. 3.Department of DermatologyMount Sinai School of MedicineNew YorkUSA

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