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Pyoderma Gangrenosum

  • Danya Reich
  • Corinna Eleni Psomadakis
  • Bobby Buka
Chapter

Abstract

Pyoderma gangrenosum is a rare inflammatory skin condition that causes painful, non-healing ulcers. The exact cause is unknown, but it is thought to be mediated by autoimmune processes, particularly involving dysregulated neutrophils. Over half the cases are associated with other autoimmune conditions, especially inflammatory bowel disease and rheumatoid arthritis. The ulcers of pyoderma gangrenosum develop rapidly, often at the site of a minor injury, and are characterized by a distinct purple border. Pyoderma gangrenosum is not infectious and antibiotics play no role in treatment. The mainstays of treatment are topical or systemic corticosteroids and analgesia. Recurrences are possible but may be prevented by controlling any underlying disease and avoiding injuries.

Keywords

Pyoderma gangrenosum Violaceous borders Inflammatory bowel disease Crohn’s disease Inflammation Inflammatory disorder Neutrophilic infiltration Ulcer Ulceration Necrosis Non-healing ulcer 

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Copyright information

© Springer International Publishing Switzerland 2017

Open Access This chapter is distributed under the terms of the Creative Commons Attribution Noncommercial License, which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.

Authors and Affiliations

  • Danya Reich
    • 1
  • Corinna Eleni Psomadakis
    • 2
  • Bobby Buka
    • 3
  1. 1.Department of Family MedicineMount Sinai School of Medicine Attending Mount Sinai Doctors/Beth Israel Medical Group-WilliamsburgBrooklynUSA
  2. 2.School of Medicine Imperial College LondonLondonUK
  3. 3.Department of DermatologyMount Sinai School of MedicineNew YorkUSA

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