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Molecular Characterization of Macrophage-Biomaterial Interactions

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Book cover Immune Responses to Biosurfaces

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 865))

Abstract

Implantation of biomaterials in vascularized tissues elicits the sequential engagement of molecular and cellular elements that constitute the foreign body response. Initial events include the non-specific adsorption of proteins to the biomaterial surface that render it adhesive for cells such as neutrophils and macrophages. The latter undergo unique activation and in some cases undergo cell-cell fusion to form foreign body giant cells that contribute to implant damage and fibrotic encapsulation. In this review, we discuss the molecular events that contribute to macrophage activation and fusion with a focus on the role of the inflammasome, signaling pathways such as JAK/STAT and NF-κB, and the putative involvement of micro RNAs in the regulation of these processes.

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Authors and Affiliations

  1. Department of Genetics, Yale University, New Haven, CT, USA

    Laura Beth Moore

  2. Vascular Biology and Therapeutics Program, Yale University, New Haven, CT, USA

    Laura Beth Moore & Themis R. Kyriakides Ph.D.

  3. Biomedical Engineering, Yale University, New Haven, CT, USA

    Themis R. Kyriakides Ph.D.

  4. Department of Pathology, Yale University School of Medicine, New Haven, CT, 06519, USA

    Themis R. Kyriakides Ph.D.

Authors
  1. Laura Beth Moore
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Correspondence to Themis R. Kyriakides Ph.D. .

Editor information

Editors and Affiliations

  1. Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

    John D. Lambris

  2. Immunology, Genetics and Pathology, University of Uppsala, Uppsala, Sweden

    Kristina N. Ekdahl

  3. Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

    Daniel Ricklin

  4. Immunology, Genetics and Pathology, University of Uppsala, Uppsala, Sweden

    Bo Nilsson

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Moore, L.B., Kyriakides, T.R. (2015). Molecular Characterization of Macrophage-Biomaterial Interactions. In: Lambris, J., Ekdahl, K., Ricklin, D., Nilsson, B. (eds) Immune Responses to Biosurfaces. Advances in Experimental Medicine and Biology, vol 865. Springer, Cham. https://doi.org/10.1007/978-3-319-18603-0_7

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