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Development of Fimbrolides, Halogenated Furanones and their Derivatives as Antimicrobial Agents

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Antibacterial Surfaces

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Abstract

Traditional treatment for bacterial infection is based on compounds that target bacterial viability or growth. However, a major concern with this approach is the frequent development of drug-resistant mutants. The discovery of bacterial quorum sensing (QS) systems, which control fundamental processes involved in bacterial physiology and virulence, has opened new avenues for the development of antimicrobial agents for the control of bacterial infections. Fimbrolides isolated from Australian native marine alga Delisea pulchra are excellent examples of QS inhibitors provided by nature. Fimbrolides and their analogues exhibit excellent QS inhibitory activity without interfering with bacterial growth, and thus offer promising targets for development of new strategies to control microbial colonisation of surfaces. This chapter describes the types of natural fimbrolides, their biosynthesis, and synthesis of related halogenated furanone and dihydropyrrolone analogues, as well as their biological activities and applications as antimicrobial coatings for the prevention of bacterial infections.

* Author contributed equally with all other contributors.

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    Authors and Affiliations

    1. School of Chemistry, University of New South Wales, Sydney, NSW, 2052, Australia

      Kitty K. K. Ho, Samuel K. Kutty, Daniel Chan, Renxun Chen & Naresh Kumar

    2. School of Optometry and Vision Science, University of New South Wales, Sydney, NSW, 2052, Australia

      Mark D. P. Willcox

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    1. School of Science, Faculty of Science, Engineering and Technology, Swinburne University of Technology, Hawthorn, Australia

      Elena Ivanova

    2. School of Science, Faculty of Science, Engineering and Technology, Swinburne University of Technology, Hawthorne, Australia

      Russell Crawford

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    Ho, K.K.K., Kutty, S.K., Chan, D., Chen, R., Willcox, M.D.P., Kumar, N. (2015). Development of Fimbrolides, Halogenated Furanones and their Derivatives as Antimicrobial Agents. In: Ivanova, E., Crawford, R. (eds) Antibacterial Surfaces. Springer, Cham. https://doi.org/10.1007/978-3-319-18594-1_8

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