Skip to main content

Ocular Manifestations of Vitamin Disorders

  • Chapter
  • First Online:
The Eye in Pediatric Systemic Disease

Abstract

Vitamins are essential micronutrients that must be obtained from the diet. Deficiencies of vitamins A, B complex, C, D, E, and K can cause nutritional disorders associated with ophthalmic manifestations. Signs of deficiency can occur in the cornea, retina, or optic nerve, and may result in vision loss if no appropriate treatment is given. The ocular signs of vitamin deficiency are seen predominantly in developing countries, but patients with absorptive defects and/or severely restricted diets are also at risk for developing the symptoms. The systemic and ocular effects of deficiencies and excesses of specific vitamins, as well as the diagnosis and treatment of each vitamin disorder, are discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 189.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 249.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 329.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Marks J. The vitamins: their role in medical practice. Lancaster, England: MTP Press; 1985.

    Book  Google Scholar 

  2. Chan GH. Nutritional deficiency disorders. In: Harley RD, editor. Pediatric ophthalmology. 2nd ed. Philadelphia: W. B. Saunders Company; 1983. p. 957–67.

    Google Scholar 

  3. Hoyt 3rd CS. Vitamin metabolism and therapy in ophthalmology. Surv Ophthalmol. 1979;24(3):177–90.

    Article  CAS  PubMed  Google Scholar 

  4. Wolf G. A historical note on the mode of administration of vitamin A for the cure of night blindness. Am J Clin Nutr. 1978;31(2):290–2.

    CAS  PubMed  Google Scholar 

  5. Snell S. On nyctalopia with peculiar appearances on the conjunctiva. Trans Ophthalmol Soc U K. 1896;18:55–102.

    Google Scholar 

  6. Hubbenet M. Observations sur l’hemeralopie. Ann Ocul (Paris). 1860;44:293.

    Google Scholar 

  7. Bitot C. Sur une lesion conjunctivale non encore decrite, coincident avec l’hemeralopie. Gaz Hebd Med Paris. 1863;10:284–8.

    Google Scholar 

  8. Sommer A. Vitamin A, deficiency and clinical disease: an historical overview. J Nutr. 2008;138(10):1835–9.

    CAS  PubMed  Google Scholar 

  9. Hopkins FG. Feeding experiments illustrating the importance of accessory factors in normal dietaries. J Physiol. 1912;44(5–6):425–60.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. McCollum EV, Davis M. The necessity of certain lipins in the diet during growth. J Biol Chem. 1913;15:167–75.

    CAS  Google Scholar 

  11. Bloch CE. Blindness and other diseases in children arising from deficient nutrition (lack of fat-soluble A factor). Am J Dis Child. 1924;27:139–48.

    Google Scholar 

  12. Sommer A, Tarwotjo I, Djunaedi E, West KP, Loeden AA, Tilden R, Mele L, Aceh Study Group. Impact of vitamin A supplementation on childhood mortality. A randomised controlled community trial. Lancet. 1986;327(8491):1169–73.

    Article  Google Scholar 

  13. West KP, Pokhrel RP, Katz J, LeClerq SC, Khatry SK, Shrestha SR, et al. Efficacy of vitamin A in reducing preschool child mortality in Nepal. Lancet. 1991;338(8759):67–71.

    Article  PubMed  Google Scholar 

  14. Rahmathullah L, Underwood BA, Thulasiraj RD, Milton RC, Ramaswamy K, Rahmathullah R, et al. Reduced mortality among children in Southern India receiving a small weekly dose of vitamin A. N Engl J Med. 1990;323(14):929–35.

    Article  CAS  PubMed  Google Scholar 

  15. Akhtar S, Ahmed A, Randhawa MA, Atukorala S, Arlappa N, Ismail T, et al. Prevalence of vitamin A deficiency in South Asia: causes, outcomes, and possible remedies. J Health Popul Nutr. 2013;31(4):413–23.

    PubMed  PubMed Central  Google Scholar 

  16. WHO. Global prevalence of vitamin A deficiency in populations at risk 1995–2005. WHO global database on vitamin A deficiency. Geneva: World Health Organization; 2009.

    Google Scholar 

  17. Sommer A. Vitamin A, deficiency and its consequences: a field guide to detection and control. 3rd ed. Geneva: World Health Organization; 1995.

    Google Scholar 

  18. Sommer A, Katz J, Tarwotjo I. Increased risk of respiratory disease and diarrhea in children with preexisting vitamin A deficiency. Am J Clin Nutr. 1984;40(5):1090–5.

    CAS  PubMed  Google Scholar 

  19. Sommer A. Mortality associated with mild, untreated xerophthalmia. Trans Am Ophthalmol Soc. 1983;81:825–53.

    CAS  PubMed  PubMed Central  Google Scholar 

  20. Imdad A, Herzer K, Mayo-Wilson E, Yakoob MY, Bhutta ZA. Vitamin A supplementation for preventing morbidity and mortality in children from 6 months to 5 years of age. Cochrane Database Syst Rev. 2010, Issue 12. Art. No.: CD008524. doi: 10.1002/14651858.CD008524.pub2.

  21. Brooks HL, Driebe WT, Schemmer GG. Xerophthalmia and cystic fibrosis. Arch Ophthalmol. 1990;108(3):354–7.

    Article  PubMed  Google Scholar 

  22. Rana M, Wong-See D, Katz T, Gaskin K, Whitehead B, Jaffe A, Coakley J, Lochhead A. Fat-soluble vitamin deficiency in children and adolescents with cystic fibrosis. J Clin Pathol. 2014;67(7):605–8.

    Article  PubMed  Google Scholar 

  23. Khan AO. Xerophthalmia occurring after strabismus surgery. J AAPOS. 2004;8(2):192–3.

    Article  PubMed  Google Scholar 

  24. Cella W, Urbano AP, Vinhadelli WS, Donatti M, Rocha EM. Xerophthalmia secondary to short bowel syndrome. J Pediatr Ophthalmol Strabismus. 2002;39(2):125–7.

    PubMed  Google Scholar 

  25. Lee WB, Hamilton SM, Harris JP, Schwab IR. Ocular complications of hypovitaminosis A after bariatric surgery. Ophthalmology. 2005;112(6):1031–4.

    Article  PubMed  Google Scholar 

  26. Tripathi RC, Tripathi BJ, Raja SC, Partamian LS. Iatrogenic ocular complications in patients after jejunoileal bypass surgery. Int Surg. 1993;78(1):68–72.

    CAS  PubMed  Google Scholar 

  27. Quaranta L, Nascimbeni G, Semeraro F, Quaranta CA. Severe corneoconjunctival xerosis after biliopancreatic bypass for obesity (Scopinaro’s operation). Am J Ophthalmol. 1994;118(6):817–8.

    Article  CAS  PubMed  Google Scholar 

  28. Brown KH, Gaffar A, Alamgir SM. Xerophthalmia, protein-calorie malnutrition, and infections in children. J Pediatr. 1979;95(4):651–6.

    Article  CAS  PubMed  Google Scholar 

  29. Blackfan KD, Wolbach SB. Vitamin A deficiency in infants: A clinical and pathological study. J Pediatr. 1933;3(5):679–706.

    Article  Google Scholar 

  30. Wolbach SB, Howe PR. Tissue changes following deprivation of fat-soluble A vitamin. J Exp Med. 1925;42(6):753–77.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. West KP, LeClerq SC, Shrestha SR, Wu LS, Pradhan EK, Khatry SK, et al. Effects of vitamin A on growth of vitamin A-deficient children: field studies in Nepal. J Nutr. 1997;127(10):1957–65.

    CAS  PubMed  Google Scholar 

  32. Semba RD, Bloem MW. The anemia of vitamin A deficiency: epidemiology and pathogenesis. Eur J Clin Nutr. 2002;56(4):271–81.

    Article  CAS  PubMed  Google Scholar 

  33. Walsh FB, Hoyt WF. Clinical neuro-ophthalmology. 3rd ed. Baltimore: Lippincott, Williams & Wilkins; 1969. Chapter 8, Metabolic and toxic diseases; p. 1026–241.

    Google Scholar 

  34. Kemp CM, Jacobson SG, Faulkner DJ, Walt RW. Visual function and rhodopsin levels in humans with vitamin A deficiency. Exp Eye Res. 1988;46(2):185–97.

    Article  CAS  PubMed  Google Scholar 

  35. Semba RD, Wirasasmita S, Natadisastra G, Muhilal, Sommer A. Response of Bitot’s spots in preschool children to vitamin A treatment. Am J Ophthalmol. 1990;110(4):416–20.

    Article  CAS  PubMed  Google Scholar 

  36. Rustgi AK, Camp MW, Marcus DM. Gastrointestinal and nutritional disorders. In: Albert DM, Jakobiec FA, editors. Principles and practice of ophthalmology. 2nd ed. Philadelphia: W. B. Saunders Company; 2000. p. 4653–64.

    Google Scholar 

  37. Tielsch JM, Sommer A. The epidemiology of vitamin A deficiency and xerophthalmia. Annu Rev Nutr. 1984;4:183–205.

    Article  CAS  PubMed  Google Scholar 

  38. Carlier C, Coste J, Etchepare M, Amédée-Manesme O. Conjunctival impression cytology with transfer as a field-applicable indicator of vitamin A status for mass screening. Int J Epidemiol. 1992;21(2):373–80.

    Article  CAS  PubMed  Google Scholar 

  39. Rahman MM, Mahalanabis D, Wahed MA, Islam M, Habte D, Khaled MA, et al. Conjunctival impression cytology fails to detect subclinical vitamin A deficiency in young children. J Nutr. 1995;125(7):1869–74.

    CAS  PubMed  Google Scholar 

  40. Chowdhury S, Kumar R, Ganguly NK, Kumar L, Nain CK, Walia BN. Conjunctival impression cytology with transfer (CICT) to detect pre-clinical vitamin A deficiency among slum children in India. Br J Nutr. 1996;75(5):785–90.

    Article  CAS  PubMed  Google Scholar 

  41. Fuchs GJ, Ausayakhun S, Ruckphaopunt S, Tansuhaj A, Suskind RM. Relationship between vitamin A deficiency, malnutrition, and conjunctival impression cytology. Am J Clin Nutr. 1994;60(2):293–8.

    CAS  PubMed  Google Scholar 

  42. WHO; UNICEF; IVACG Task Force. Vitamin A supplements: a guide to their use in the treatment and prevention of vitamin A deficiency and xerophthalmia. 2nd ed. Geneva: World Health Organization; 1997.

    Google Scholar 

  43. WHO. Guideline: Vitamin A supplementation in infants and children 6–59 months of age. Geneva: World Health Organization; 2011.

    Google Scholar 

  44. Bauernfeind JC. The safe use of vitamin A: a report of the International Vitamin A Consultative Group (IVACG). Washington, DC: International Vitamin A Consultative Group; 1980.

    Google Scholar 

  45. Sommer A, Emran N. Topical retinoic acid in the treatment of corneal xerophthalmia. Am J Ophthalmol. 1978;86(5):615–7.

    Article  CAS  PubMed  Google Scholar 

  46. Berson EL, Rosner B, Sandberg MA, Hayes KC, Nicholson BW, Weigel-DiFranco C, et al. A randomized trial of vitamin A and vitamin E supplementation for retinitis pigmentosa. Arch Ophthalmol. 1993;111(6):761–72.

    Article  CAS  PubMed  Google Scholar 

  47. NEI statement: Update on vitamin A as a treatment for retinitis pigmentosa. Optom Vis Sci. 2008;85(9):E790–1.

    Google Scholar 

  48. Lanska DJ. Historical aspects of the major neurological vitamin deficiency disorders: the water-soluble B vitamins. Handb Clin Neurol. 2010;95:445–76.

    Article  PubMed  Google Scholar 

  49. Crandall BF, Corson VL, Evans MI, Goldberg JD, Knight G, Salafsky IS. American College of Medical Genetics statement on folic acid: fortification and supplementation. Am J Med Genet. 1998;78(4):381.

    Article  CAS  PubMed  Google Scholar 

  50. FAO; WHO. Human vitamin and mineral requirements. Report of a joint FAO/WHO expert consultation. Bangkok, Thailand. Rome: FAO; 2001.

    Google Scholar 

  51. Kerns JC, Arundel C, Chawla LS. Thiamin deficiency in people with obesity. Adv Nutr. 2015;6(2):147–53.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  52. Aasheim ET. Wernicke encephalopathy after bariatric surgery: a systematic review. Ann Surg. 2008;248(5):714–20.

    PubMed  Google Scholar 

  53. Coats D, Shelton-Dodge K, Ou K, Khun V, Seab S, Sok K, et al. Thiamine deficiency in Cambodian infants with and without beriberi. J Pediatr. 2012;161(5):843–7.

    Article  CAS  PubMed  Google Scholar 

  54. Fattal-Valevski A, Kesler A, Sela BA, Nitzan-Kaluski D, Rotstein M, Mesterman R, et al. Outbreak of life-threatening thiamine deficiency in infants in Israel caused by a defective soy-based formula. Pediatrics. 2005;115(2):e233–8.

    Article  PubMed  Google Scholar 

  55. Katsura E, Oiso T. Beriberi. In: Beaton GH, Bengoa JM, editors. World Health Organization monograph series no. 62: nutrition in preventive medicine. Geneva: World Health Organization; 1976. p. 136–45.

    Google Scholar 

  56. Stallings VA, Mascarenhas MR. Vitamin deficiencies and excesses. In: Burg FD, Ingelfinger JR, Wald ER, Polin RA, editors. Gellis & Kagan’s current pediatric therapy. 15th ed. Philadelphia: W. B. Saunders Company; 1996. p. 15–20.

    Google Scholar 

  57. Koike H, Takahashi M, Ohyama K, Hashimoto R, Kawagashira Y, Iijima M, et al. Clinicopathologic features of folate-deficiency neuropathy. Neurology. 2015;84(10):1026–33.

    Article  CAS  PubMed  Google Scholar 

  58. Black MM. Effects of vitamin B12 and folate deficiency on brain development in children. Food Nutr Bull. 2008;29(2 Suppl):S126–31.

    Article  PubMed  PubMed Central  Google Scholar 

  59. Pott JW, Wong KH. Leber’s hereditary optic neuropathy and vitamin B12 deficiency. Graefes Arch Clin Exp Ophthalmol. 2006;244(10):1357–9.

    Article  CAS  PubMed  Google Scholar 

  60. Van Noort BA, Bos PJ, Klopping C, Wilmink JM. Optic neuropathy from thiamine deficiency in a patient with ulcerative colitis. Doc Ophthalmol. 1987;67(1–2):45–51.

    Article  PubMed  Google Scholar 

  61. Hoyt 3rd CS, Billson FA. Low-carbohydrate diet optic neuropathy. Med J Aust. 1977;1(3):65–6.

    PubMed  Google Scholar 

  62. Golnik KC, Schaible ER. Folate-responsive optic neuropathy. J Neuroophthalmol. 1994;14(3):163–9.

    Article  CAS  PubMed  Google Scholar 

  63. Hsu CT, Miller NR, Wray ML. Optic neuropathy from folic acid deficiency without alcohol abuse. Ophthalmologica. 2002;216(1):65–7.

    Article  PubMed  Google Scholar 

  64. Damodaran M, Rameshwar Sarma KV, Tiar A, Nadamuni NA. Vitamin B-complex deficiency and visual acuity. Br J Nutr. 1979;41(1):27–30.

    Article  CAS  PubMed  Google Scholar 

  65. Akdal G, Yener GG, Ada E, Halmagyi GM. Eye movement disorders in vitamin B12 deficiency: two new cases and a review of the literature. Eur J Neurol. 2007;14(10):1170–2.

    Article  CAS  PubMed  Google Scholar 

  66. Venkataswamy G. Ocular manifestations of vitamin B-complex deficiency. Br J Ophthalmol. 1967;51(11):749–54.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  67. Bietti G. Ocular Manifestations of vitamin deficiencies and disordered vitamin metabolism. Metab Ophthalmol. 1977;1:81–9.

    CAS  Google Scholar 

  68. Lee OS, Hart WM. The metabolism of the cornea: Studies on the oxygen consumption of corneas of riboflavin and vitamin-A-deficient rats. Am J Ophthalmol. 1944;27(5):488–500.

    Article  CAS  Google Scholar 

  69. Irinoda K, Mikami H. Angular blepharoconjunctivitis and pyridoxine (vitamin B6) deficiency. Arch Ophthalmol. 1958;60(2):303–11.

    Article  CAS  Google Scholar 

  70. Lind J. A treatise of the scurvy. In three parts. Containing an inquiry into the nature, causes and cure, of that disease. Together with a critical and chronological view of what has been published on the subject. Edinburgh: Printed by Sands, Murray and Cochran for A Kincaid and A Donaldson; 1753.

    Google Scholar 

  71. Schleicher RL, Carroll MD, Ford ES, Lacher DA. Serum vitamin C and the prevalence of vitamin C deficiency in the United States: 2003–2004 National Health and Nutrition Examination Survey (NHANES). Am J Clin Nutr. 2009;90(5):1252–63.

    Article  CAS  PubMed  Google Scholar 

  72. Mosdøl A, Erens B, Brunner EJ. Estimated prevalence and predictors of vitamin C deficiency within UK’s low-income population. J Public Health (Oxf). 2008;30(4):456–60.

    Article  Google Scholar 

  73. Khouri LM, Kersten RC, Kulwin DR. Bilateral subperiosteal orbital hematomas in a child with sickle cell disease. J Pediatr Ophthalmol Strabismus. 2002;39(3):182–4.

    PubMed  Google Scholar 

  74. Sloan B, Kulwin DR, Kersten RC. Scurvy causing bilateral orbital hemorrhage. Arch Ophthalmol. 1999;117(6):842–3.

    Article  CAS  PubMed  Google Scholar 

  75. Dunnington J. Exophthalmos in infantile scurvy. Trans Am Ophthalmol Soc. 1931;29:37–47.

    CAS  PubMed  PubMed Central  Google Scholar 

  76. Food and Nutrition Board, Institute of Medicine. Dietary reference intakes for vitamin C, vitamin E, selenium, and carotenoids. Washington, DC: National Academy Press; 2000.

    Google Scholar 

  77. Misra M, Pacaud D, Petryk A, Collett-Solberg PF, Kappy M, Drug and Therapeutics Committee of the Lawson Wilkins Pediatric Endocrine Society. Vitamin D deficiency in children and its management: review of current knowledge and recommendations. Pediatrics. 2008;122(2):398–417.

    Article  PubMed  Google Scholar 

  78. Rosenblum JL, Keating JP, Prensky AL, Nelson JS. A progressive neurologic syndrome in children with chronic liver disease. N Engl J Med. 1981;304(9):503–8.

    Article  CAS  PubMed  Google Scholar 

  79. Guggenheim MA, Ringel SP, Silverman A, Grabert BE. Progressive neuromuscular disease in children with chronic cholestasis and vitamin E deficiency: Diagnosis and treatment with alpha tocopherol. J Pediatr. 1982;100(1):51–8.

    Article  CAS  PubMed  Google Scholar 

  80. Guggenheim MA, Jackson V, Lilly J, Silverman A. Vitamin E deficiency and neurologic disease in children with cholestasis: A prospective study. J Pediatr. 1983;102(4):577–9.

    Article  CAS  PubMed  Google Scholar 

  81. Machlin LJ, Filipski R, Nelson J, Horn LR, Brin M. Effects of a prolonged vitamin E deficiency in the rat. J Nutr. 1977;107(7):1200–8.

    CAS  PubMed  Google Scholar 

  82. Pentschew A, Schwarz K. Systemic axonal dystrophy in vitamin E deficient adult rats. Acta Neuropathol. 1962;1(4):313–34.

    Article  Google Scholar 

  83. Oski FA, Barness LA. Hemolytic anemia in vitamin E deficiency. Am J Clin Nutr. 1968;21(1):45–50.

    CAS  PubMed  Google Scholar 

  84. Goss-Sampson M, Vivian AJ, Kelly FJ. Free radicals, inflammation and eye diseases. In: Blake D, Winyard PG, editors. Immunopharmacology of free radical species. London: Academic Press; 1995. p. 127–42,I.

    Google Scholar 

  85. Ko ML, Peng PH, Hsu SY, Chen CF. Dietary deficiency of vitamin E aggravates retinal ganglion cell death in experimental glaucoma of rats. Curr Eye Res. 2010;35(9):842–9.

    Article  CAS  PubMed  Google Scholar 

  86. Hayes KC. Retinal degeneration in monkeys induced by deficiencies of vitamin E or A. Invest Ophthalmol. 1974;13(7):499–510.

    CAS  PubMed  Google Scholar 

  87. Muller DP. Vitamin E, and neurological function. Mol Nutr Food Res. 2010;54(5):710–8.

    Article  CAS  PubMed  Google Scholar 

  88. Berger AS, Tychsen L, Rosenblum JL. Retinopathy in human vitamin E deficiency. Am J Ophthalmol. 1991;111(6):774–5.

    Article  CAS  PubMed  Google Scholar 

  89. Greenbaum LA. Vitamin E deficiency. In: Kliegman RM, Stanton BF, St. Geme JW, Schor NF, Behrman RE, editors. Nelson textbook of pediatrics. 19th ed. Philadelphia: Saunders; 2011. p. 209.

    Google Scholar 

  90. Brion LP, Bell EF, Raghuveer TS. Vitamin E supplementation for prevention of morbidity and mortality in preterm infants. Cochrane Database Syst Rev. 2003, Issue 4. Art. No.: CD003665. doi: 10.1002/14651858.CD003665.

  91. American Academy of Pediatrics, Committee on Nutrition. Vitamin K compounds and the water-soluble analogues: use in therapy and prophylaxis in pediatrics. Pediatrics.1961;28:501–7

    Google Scholar 

  92. Miller C, Newborn Co Fa, Pediatrics AAO. American Academy of Pediatrics Policy Statement: Controversies concerning vitamin K and the newborn. Pediatrics. 2003;112:191–2.

    Article  Google Scholar 

  93. Lane PA, Hathaway WE. Vitamin K in infancy. J Pediatr. 1985;106(3):351–9.

    Article  CAS  PubMed  Google Scholar 

  94. Behrmann B, Chan W, Finer N. Resurgence of hemorrhagic disease of the newborn: a report of three cases. Can Med Assoc J. 1985;133:884–5.

    CAS  PubMed Central  Google Scholar 

  95. Appendini M, Gastalso E, Moresco W, Peisino M, Torta L. L’emorragia da deficit di vitamina K in epoca post-neonatale. Minerva Pediatr. 1989;41:77–83.

    CAS  PubMed  Google Scholar 

  96. Brousseau TJ, Kissoon N, McIntosh B. Vitamin K deficiency mimicking child abuse. The Journal of emergency medicine. 2005;29(3):283–8.

    Article  PubMed  Google Scholar 

  97. Hathaway W. Vitamin K, deficiency. Southeast Asian J Trop Med Public Health. 1993;24 Suppl 1:5–9.

    PubMed  Google Scholar 

  98. Soylu H, Aslan Y, Sari A, Erduran E. Intracerebral hemorrhage: a rare late manifestation of vitamin-K deficiency in a breastfed infant. Turkish J Pediatr. 1997;39:265–9.

    CAS  Google Scholar 

  99. Van Winckel M, De Bruyne R, Van de Velde S, Biervliet V. Vitamin K, an update for the paediatrician. European journal of pediatrics. 2008.

    Google Scholar 

  100. Carpenter SL, Abshire TC, Anderst JD. Evaluating for suspected child abuse: conditions that predispose to bleeding. Pediatrics. 2013;131(4):e1357–73. Epub 2013/03/27.

    Article  PubMed  Google Scholar 

  101. Sutor A, Dagres N, Niederhoff H. Late form of vitamin K deficiency bleeding in Germany. Klin Padiatr. 1995;207:89–97.

    Article  CAS  PubMed  Google Scholar 

  102. Auerswald G, Sutor A, editors. Thirteen cases of alpha 1-antitrypsin deficiency presenting as a bleeding diathesis with intracranial hemorrhage in the newborn. Vitamin K in infancy: International Symposium; 1995; Basel. Switzerland: Schauttauer; 1994.

    Google Scholar 

  103. Payne NR, Hasegawa DK. Vitamin K deficiency in newborns: a case report in alpha-1-antitrypsin deficiency and a review of factors predisposing to hemorrhage. Pediatrics. 1984;73(5):712–6.

    CAS  PubMed  Google Scholar 

  104. Hoyt CS. Therapeutic review. Vitamin metabolism and therapy in ophthalmology. Surv Ophthalmol. 1979;24:185.

    Article  Google Scholar 

  105. Shemie S, Cutz E. Late hemorrhagic disease of the newborn: a fatal presentation of hepatobiliary disease masquerading as shaken baby syndrome. Intensive Care Med. 1995;10:315–8.

    Article  Google Scholar 

  106. Sutor AH, von Kries R, Cornelissen EA, et al. Vitamin K deficiency bleeding (VKDB) in infancy. ISTH Pediatric/Perinatal Subcommittee. International Society on Thrombosis and Haemostasis. Thromb Haemost. 1999;81:456–61.

    CAS  PubMed  Google Scholar 

  107. Miyasaka M, Nosaka S, Sakai H, Tsutsumi Y, Kitamura M, Miyazaki O, et al. Vitamin K deficiency bleeding with intracranial hemorrhage: focus on secondary form. Emerg Radiol. 2007.

    Google Scholar 

  108. Wille H. Investigation in the influence of K avitaminosis in the occurrence of retinal hemorrhages in the newborn. A preliminary report. Acta Ophthalmologica. 1944;22:61–9.

    Google Scholar 

  109. Danielsson N, Hoa D, Thang N, Vos T, Loughnan P. Intracranial haemorrhage due to late onset vitamin K deficiency bleeding in Hanoi province, Vietnam. Arch Dis Child Fetal Neonatal Ed. 2004;89:F546–50.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  110. Chaou W, Chou M, Eitzman D. Intracranial hemorrhage and vitamin K deficiency in early infancy. J Pediatr. 1984;105(6):880–4.

    Article  CAS  PubMed  Google Scholar 

  111. Matsuzaka T, Yoshinaga M, Tsuji Y, Yasunaga A, Mori K. Incidence and causes of intracranial hemorrhage in infancy: a prospective surveillance study after vitamin K prophylaxis. Brain & development. 1989;11(6):384–408.

    Article  CAS  Google Scholar 

  112. Bor O, Akgun N, Yakut A, Sarhus F, Kose S. Late hemorrhagic disease of the newborn. Pediatr Int. 2000;42(1):64–6. Epub 2000/03/07.

    Article  CAS  PubMed  Google Scholar 

  113. Demiroren K, Yavuz H, Cam L. Intracranial hemorrhage due to vitamin K deficiency after the newborn period. Pediatr Hematol Oncol. 2004;21(7):585–92. Epub 2005/01/01.

    Article  PubMed  CAS  Google Scholar 

  114. Rutty G, Smith G, Malia R. Late-form hemorrhagic disease of the newborn: a fatal case report with illustration of investigations that may assist in avoiding the mistaken diagnosis of child abuse. The American journal of forensic medicine and pathology. 1999;20(1): 48–51.

    Article  CAS  PubMed  Google Scholar 

  115. Cekinmez M, Cemil T, Cekinmez EK, Altinors N. Intracranial hemorrhages due to late-type vitamin K deficiency bleeding. Child’s Nervous Syst. 2007.

    Google Scholar 

  116. Yilmaz C, Yuca SA, Yilmaz N, Bektas MS, Caksen H. Intracranial hemorrhage due to vitamin K deficiency in infants: a clinical study. Int J Neurosci. 2009;119(12):2250–6. Epub 2009/11/18.

    Article  CAS  PubMed  Google Scholar 

  117. Van den Anker J, Sinaasappel M. Bleeding as a presenting symptom of cholestasis. J Perinatol. 1993;13(4):322–4.

    PubMed  Google Scholar 

  118. Wetzel R, Slater A, Dover G. Fatal intramuscular bleeding misdiagnosed as suspected nonaccidental injury. Pediatrics. 1995;95:771–3.

    CAS  PubMed  Google Scholar 

  119. Lane P, Hathaway W, Githens J, Krugman R, Rosenberg D. Fatal intracranial hemorrhage in a normal infant secondary to vitamin K deficiency. Pediatrics. 1983;72:562–4.

    CAS  PubMed  Google Scholar 

  120. Goldman HI, Deposito F. Hypoprothrombinemic bleeding in young infants. Association with diarrhea, antibiotics, and milk substitutes. Am J Dis Child. 1966;111(4):430–2.

    Article  CAS  PubMed  Google Scholar 

  121. Anderst JD, Carpenter SL, Abshire TC. Evaluation for bleeding disorders in suspected child abuse. Pediatrics. 2013;131(4):e1314–22. Epub 2013/03/27.

    Article  PubMed  Google Scholar 

  122. Per H, Kumandas S, Ozdemir MA, Gumus H, Karakukcu M. Intracranial hemorrhage due to late hemorrhagic disease in two siblings. The Journal of emergency medicine. 2006;31(1):49–52.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to David S. Walton M.D. .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Choi, E.Y., Neustein, R.F., Krebs, N.F., Walton, D.S. (2017). Ocular Manifestations of Vitamin Disorders. In: Levin, A., Enzenauer, R. (eds) The Eye in Pediatric Systemic Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-18389-3_22

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-18389-3_22

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-18388-6

  • Online ISBN: 978-3-319-18389-3

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics