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Hormonal Regulation and Systemic Signals of Skin Aging

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Advances in Geriatric Dermatology

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Abstract

Tissues throughout the body share a common systemic environment comprising the multitude of circulating factors transported within the vasculature. These circulating factors, including hormones and nutrients, represent many key determinants of cell growth and function. As animals age, the balance of factors in the systemic circulation shifts and thus alters the cellular environment. The age-dependent changes in the systemic circulation exposes tissues, including skin, to a distinct combination of factors that is reflected by alterations in cell and tissue phenotypes with age. This chapter discusses our current understanding of the changes to the systemic milieu that occur as mammals grow old, the influence of these changes on skin health and disease in aged individuals, and the efforts to therapeutically modulate circulating factors to prevent or reverse aging phenotypes.

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Authors and Affiliations

  1. Departments of Dermatology and Pathology, Stanford University School of Medicine, 450 Broadway St., Redwood City, CA, 94063, USA

    Gregory W. Charville

  2. Department of Dermatology, Stanford University School of Medicine, 450 Broadway Street, MC5334, Redwood City, CA, 94063, USA

    Anne Lynn S. Chang M.D. (Assistant Professor)

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  1. Gregory W. Charville
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Correspondence to Gregory W. Charville .

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  1. Standford University School of Medicine, Redwood City, California, USA

    Anne Lynn S. Chang

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Charville, G.W., Chang, A.L.S. (2015). Hormonal Regulation and Systemic Signals of Skin Aging. In: Chang, A. (eds) Advances in Geriatric Dermatology. Springer, Cham. https://doi.org/10.1007/978-3-319-18380-0_4

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  • DOI: https://doi.org/10.1007/978-3-319-18380-0_4

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