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Neuronal Genes and Developmental Neuronal Pathways in Drosophila Life Span Control

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Book cover Life Extension

Part of the book series: Healthy Ageing and Longevity ((HAL,volume 3))

Abstract

The nervous system has long been suggested as a key tissue that defines life span. The identity of neuronal cell types is established during development and maintained throughout adulthood due to the expression of specific neuronal genes coding for ion channels, neurotransmitters and neuropeptides, G-protein-coupled receptors, motor proteins, recognition and adhesion molecules. In this paper, we review data on the role of neuronal genes in Drosophila melanogaster life span control. Several pathways responsible for life span regulation are also important for the development of the nervous system. Genes involved in insulin-like, Target of Rapamycin, Janus Kinase/Signal Transducer and Activator of Transcription and cell polarity pathways, a number of global regulators and transcription factors play key roles both in aging and longevity control and in shaping the nervous system as a network of specialized neuronal cells in early development. Is their impact on life span related, at least partially, to their developmental functions or is it explained by other pleiotropic influences later in life? In this paper, we address this question based on the published data and our own findings.

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Acknowledgments

Authors are supported by the Presidium of the Russian Academy of Sciences Program “Biodiversity of natural systems” and the Russian Foundation for Basic Research grants #14-04-01464-a and #15-04-05797-a.

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Authors and Affiliations

  1. Institute of Molecular Genetics of RAS, Moscow, Russia

    Elena Pasyukova, Alexander Symonenko, Natalia Roshina, Mikhail Trostnikov, Ekaterina Veselkina & Olga Rybina

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  1. Elena Pasyukova
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  2. Alexander Symonenko
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  3. Natalia Roshina
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  4. Mikhail Trostnikov
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  5. Ekaterina Veselkina
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  6. Olga Rybina
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Correspondence to Elena Pasyukova .

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Editors and Affiliations

  1. Laboratory of Epigenetics, Institute of Gerontology, Kiev, Kievs'ka, Ukraine

    Alexander M. Vaiserman

  2. Laboratory of Molecular Radiobiology and Gerontology, Institute of Biology of Komi Science Center of Ural Branch of RAS, Syktyvkar, Komi Republic, Russia

    Alexey A. Moskalev

  3. Laboratory of Genome Variation, Institute of Molecular Genetics of RAS, Moscow, Russia

    Elena G. Pasyukova

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Pasyukova, E., Symonenko, A., Roshina, N., Trostnikov, M., Veselkina, E., Rybina, O. (2015). Neuronal Genes and Developmental Neuronal Pathways in Drosophila Life Span Control. In: Vaiserman, A., Moskalev, A., Pasyukova, E. (eds) Life Extension. Healthy Ageing and Longevity, vol 3. Springer, Cham. https://doi.org/10.1007/978-3-319-18326-8_1

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