Theories on Endometriosis

  • Sajal Gupta
  • Avi Harlev
  • Ashok Agarwal
  • Elizabeth Pandithurai
Part of the SpringerBriefs in Reproductive Biology book series (BRIEFSREPROBIO)


There are several theories as to how endometriosis develops, but the most widely accepted one is Sampson’s theory. First hypothesized in 1927, Sampson’s theory [1] states that three elements are required to cause endometriosis: retrograde menstruation, the presence of viable cells within the retrograde menstruation, and the implantation of these viable endometrial cells, which continue to grow and form peritoneal lesions [1].


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Copyright information

© The Author(s) 2015

Authors and Affiliations

  • Sajal Gupta
    • 1
  • Avi Harlev
    • 3
    • 4
  • Ashok Agarwal
    • 2
  • Elizabeth Pandithurai
    • 5
  1. 1.Assistant Professor, Lerner College of Medicine and Case Western Reserve University, American Center for Reproductive MedicineCleveland ClinicClevelandUSA
  2. 2.Professor, Lerner College of Medicine and Case Western Reserve University, American Center for Reproductive MedicineCleveland ClinicClevelandUSA
  3. 3.American Center for Reproductive MedicineClevelandUSA
  4. 4.Lecturer, Soroka University Medical Center, Fertility and IVF UnitBen-Gurion University of the NegevBeer-ShevaIsrael
  5. 5.American Center for Reproductive MedicineCleveland ClinicClevelandUSA

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