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Salivary Gland Diseases

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Genomics, Personalized Medicine and Oral Disease

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Abstract

Salivary gland diseases, which have a heterogeneous etiology, share a reduction or loss of saliva production and clinical xerostomia. These ailments may be monogenic, neoplastic, autoimmune, infectious, environmental, or multifactorial in origin, and based on that origin, the genetic contribution to their development varies. In the current chapter we focus on the genetics of Sjögren’s syndrome as a model of a multifactorial disease. We also discuss the genetic mutations that underlie autosomal dominant, autosomal recessive, and X-linked salivary gland abnormalities, as well as the role of genetic factors on the predisposition and phenotypic variation of other autoimmune and granulomatous disorders.

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Authors and Affiliations

  1. Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, MS#5, 73104, Oklahoma City, OK, USA

    Astrid Rasmussen

  2. Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, MS#24, 73104, Oklahoma City, OK, USA

    Christopher J. Lessard

  3. Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, MS#57, 73104, Oklahoma City, OK, USA

    Kathy L. Sivils

  4. Department of Pathology, University of Oklahoma Health Sciences Center, 825 NE 13th Street, MS#24, 73104, Oklahoma City, OK, USA

    Christopher J. Lessard

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  1. Astrid Rasmussen
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Correspondence to Astrid Rasmussen .

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  1. Brigham and Women’s Hospital, Boston, Massachusetts, USA

    Stephen T. Sonis, DMD, DMSc

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Rasmussen, A., Lessard, C., Sivils, K. (2015). Salivary Gland Diseases. In: Sonis, DMD, DMSc, S. (eds) Genomics, Personalized Medicine and Oral Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-17942-1_11

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