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Biennial Review of Infertility pp 223–233Cite as

Are Dietary Supplements Beneficial for IVF Patients?

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Abstract

The use of assisted reproductive technologies including in vitro fertilization is increasing globally, and modifiable factors that can improve success rates would have enormous public health significance. We review the literature on the effect of dietary supplementation on IVF outcomes including pregnancy and live birth. The main dietary factors for which there is some evidence of a relationship with these outcomes are folic acid, phytoestrogens, antioxidants, and vitamin D. Although several studies report a significant association between dietary supplementation and improved IVF outcomes, the number of large, high-quality, well-controlled, and randomized trials is limited. As a result, current evidence is not supportive of a change in practice towards routine recommendation of specific dietary supplements for the purpose of improving IVF outcomes. However, given the strength and consistency of the association between folic acid supplementation and IVF outcomes, it would be ideal if this relation were further evaluated in a large randomized controlled trial.

Keywords

  • Dietary supplements
  • In vitro fertilization
  • Infertility
  • Folic acid
  • Epidemiology

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Authors and Affiliations

  1. Boston University School of Public Health, Boston, MA, USA

    Amelia Wesselink MPH

  2. Department of Nutrition, Harvard School of Public Health, Boston, MA, USA

    Jorge E. Chavarro MD, ScD

  3. Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

    Jorge E. Chavarro MD, ScD

  4. Department of Obstetrics and Gynecology, Boston Medical Center, Boston University, Boston, MA, USA

    Shruthi Mahalingaiah MD

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  1. Jorge E. Chavarro MD, ScD
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Correspondence to Shruthi Mahalingaiah MD .

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Editors and Affiliations

  1. Professor, Departments of Surgery (Urology), Obstetrics and Gynecology, and Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah, USA

    Douglas T. Carrell

  2. James J. Colt Professor of Urology, Chairman, Department of Urology, Weill Cornell Medical College, New York Presbyterian Hospital, New York, New York, USA

    Peter N. Schlegel

  3. Professor, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA

    Catherine Racowsky

  4. Scientific Director, Reproductive Medicine Unit, S.I.S.M.E.R. s.r.l., Day Surgery Clinic della Riproduzione (SISMeR), Bologna, Bologna, Italy

    Luca Gianaroli

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Wesselink, A., Chavarro, J.E., Mahalingaiah, S. (2015). Are Dietary Supplements Beneficial for IVF Patients?. In: Carrell, D., Schlegel, P., Racowsky, C., Gianaroli, L. (eds) Biennial Review of Infertility. Springer, Cham. https://doi.org/10.1007/978-3-319-17849-3_16

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