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Are Dietary Supplements Beneficial for IVF Patients?

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Abstract

The use of assisted reproductive technologies including in vitro fertilization is increasing globally, and modifiable factors that can improve success rates would have enormous public health significance. We review the literature on the effect of dietary supplementation on IVF outcomes including pregnancy and live birth. The main dietary factors for which there is some evidence of a relationship with these outcomes are folic acid, phytoestrogens, antioxidants, and vitamin D. Although several studies report a significant association between dietary supplementation and improved IVF outcomes, the number of large, high-quality, well-controlled, and randomized trials is limited. As a result, current evidence is not supportive of a change in practice towards routine recommendation of specific dietary supplements for the purpose of improving IVF outcomes. However, given the strength and consistency of the association between folic acid supplementation and IVF outcomes, it would be ideal if this relation were further evaluated in a large randomized controlled trial.

Keywords

  • Dietary supplements
  • In vitro fertilization
  • Infertility
  • Folic acid
  • Epidemiology

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Wesselink, A., Chavarro, J.E., Mahalingaiah, S. (2015). Are Dietary Supplements Beneficial for IVF Patients?. In: Carrell, D., Schlegel, P., Racowsky, C., Gianaroli, L. (eds) Biennial Review of Infertility. Springer, Cham. https://doi.org/10.1007/978-3-319-17849-3_16

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  • DOI: https://doi.org/10.1007/978-3-319-17849-3_16

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