Urosepsis-Pathogenesis and Treatment
Urosepsis is a life-threatening infection that results from the interaction of bacteria and bacterial products with the host immune system, resulting in a clinically unstable patient. Pathogen factors include the virulence of particular bacterial strains/subtypes which produce toxins, most commonly components of the bacterial cell wall, that amplify and exaggerate the host immune response. Patient factors that contribute to the development of urosepsis include a compromised immune system incapable of effectively clearing infection, as seen in patients with uncontrolled HIV or patients taking chronic immunosuppression (i.e. chronic steroid use). Certain urologic conditions, specifically the obstruction of urinary flow secondary to urolithiasis or benign prostatic hyperplasia (BPH), can result in the rapid development of urosepsis. Successful management of sepsis requires early identification of clinical sepsis, prompt fluid resuscitation and administration of antibiotics, and relief of obstruction.
KeywordsSource Control Renal Abscess Sepsis Mortality Emphysematous Pyelonephritis Acute Bacterial Prostatitis
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