Fischmann presents an interdisciplinary combination of psychoanalysis and neuroscience, in which she focuses on different approaches towards dreams, the dreaming mind, and the brain from a psychoanalytical, neuropsychoanalytical and neurobiological stance. The current FRED study continues to investigate changes in brain functions in chronically depressed patients after long-term therapies, looking for multi-modal neurobiological changes in the course of psychotherapy. Data from both neurobiology and psychoanalysis suggest that emotionally meaningful life experiences are encoded in memory by sensory percepts. These encoded memories will then recur in dreams. Therefore, dreaming can no longer be considered as random and meaningless. The author further links dreams and unconscious fantasies with epigenetics. The fact that epigenetic regulation, that is, chromatin remodeling in neurons, not only occurs in the developing brain but also in the mature, fully differentiated brain, raises questions about psychodynamic interactions in the developing mind that we are just now beginning to understand.


Dreams FRED study Epigenetics Mind-brain relationship Nachträglichkeit Nodal images REM sleep “Dream of the botanical monograph” 


  1. Arlow, J. A., & Brenner, C. (1964). Psychoanalytic concepts and the structural theory. Oxford: International Universities Press.Google Scholar
  2. Belmaker, R. H., & Agam, G. (2008). Major depressive disorder. New England Journal of Medicine, 358(1), 55–68.CrossRefGoogle Scholar
  3. Bion, W. (1963). Elements of psycho-analysis. London: Heinemann.Google Scholar
  4. Bonomi, C. (2003). Between symbol and antisymbol – The meaning of trauma reconsidered. International Forum of Psychoanalysis, 12(1), 17–21.CrossRefGoogle Scholar
  5. Botvinick, M. M., Cohen, J. D., & Carter, C. S. (2004). Conflict monitoring and anterior cingulate cortex: An update. Trends in Cognitive Sciences, 8(12), 539–546.CrossRefGoogle Scholar
  6. Braun, A. R., Balkin, T. J., Wesensten, N. J., Gwadry, F., Carson, R. E., Varga, M., Baldwin, P., Belenky, G., & Herscovitch, P. (1998). Dissociated patterns of activity in visual cortices and their projections during human rapid eye movement sleep. Science, 279, 91–95.CrossRefGoogle Scholar
  7. Cartwright, R. D. (1977). Night life: Explorations in dreaming. Oxford: Prentice-Hall.Google Scholar
  8. Cartwright, R. D. (1991). Dreams that work: The relation of dream incorporation to adaptation to stressful events. Dreaming, 1(1), 3–9.CrossRefGoogle Scholar
  9. Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H. L., McClay, J., Mill, J., Martin, J., Braithwaite, A., & Poulton, R. (2003). Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene. Science, 301(5631), 386–389.CrossRefGoogle Scholar
  10. Collins, W. A., Maccoby, E. E., Steinberg, L., Hetherington, E. M., & Bornstein, M. H. (2000). Contemporary research on parenting: The case for nature and nurture. American Psychologist, 55(2), 218–232.CrossRefGoogle Scholar
  11. Critchley, H. (2003). Emotion and its disorders. British Medical Bulletin, 65, 33–47.CrossRefGoogle Scholar
  12. Dewan, E. M. (1970). The programing (P) hypothesis for REM sleep. International Psychiatry Clinics, 7(2), 295–307.Google Scholar
  13. Freud, S. (1895). Project for a scientific psychology. S.E. I.Google Scholar
  14. Freud, S. (1900). Interpretation of dreams. S.E. IV.Google Scholar
  15. Freud, S. (1916). Introductory lectures on psychoanalysis. S.E. XV.Google Scholar
  16. Freud, S. (1920). Beyond the pleasure principle. S.E. XVIII.Google Scholar
  17. Greenberg, R., & Pearlman, C. (1974). REM sleep and the analytic process: A psychophysiologic bridge. Psychoanalytic Quarterly, 44, 392–402.Google Scholar
  18. Greenberg, R., Pearlman, C., Blacher, R., Katz, H., Sashin, J., & Gottlieb, P. (1990). Depression: Variability of intrapsychic and sleep parameters. The Journal of the American Academy of Psychoanalysis, 18, 233–246.Google Scholar
  19. Hobson, J. A. (1999). The new neuropsychology of sleep: Implications for psychoanalysis. Neuropsychoanalysis, 1, 157–183.CrossRefGoogle Scholar
  20. Hobson, J. A., & McCarley, R. W. (1977). The brain as a dream state generator: An activation-synthesis hypothesis of the dream process. American Journal of Psychiatry, 134(12), 1335–1348.CrossRefGoogle Scholar
  21. Hopkins, J. (1992). Psychoanalysis interpretation and science. In J. Hopkins & A. Saville (Eds.), Psychoanalysis mind and art. Oxford: Blackwell.Google Scholar
  22. Kandel, E. R. (1999). Biology and the future of psychoanalysis: A new intellectual framework for psychiatry revisited. American Journal of Psychiatry, 156(4), 505–524.Google Scholar
  23. Kellermann, N. P. F. (2011). Geerbtes Trauma: Die Konzeptualisierung der trans-generationalen Weitergabe von Traumata. In Tel Aviver Jahrbuch für Deutsche Geschichte (Vol. 39). Göttingen: Wallstein Verlag.Google Scholar
  24. Klein, M. (1948). Contributions to psychoanalysis 1921–1945. London: Hogarth Press.Google Scholar
  25. Laub, D. (2005). Traumatic shutdown of narrative and symbolization: A death instinct derivative? Contemporary Psychoanalysis, 41(2), 307–326.CrossRefGoogle Scholar
  26. Lester, B. M., Tronick, E., Nestler, E., Abel, T., Kosofsky, B., Kuzawa, C. W., Marsit, C. J., Maze, I., Meaney, M. J., Monteggia, L. M., Reul, J. M. H. M., Skuse, D. H., Sweatt, J. D., & Wood, M. A. (2011). Behavioral epigenetics. Annals of the New York Academy of Sciences (Issue: Annals Meeting Reports), 1226(1), 14–33.CrossRefGoogle Scholar
  27. Maquet, P., Peters, J.-M., Aerts, J., Delfiore, G., Degueldre, C., Luxen, A., & Franck, G. (1996). Functional neuroanatomy of human rapid-eye-movement sleep and dreaming. Nature, 383, 163–166.CrossRefGoogle Scholar
  28. Matsumoto, K., Suzuki, W., & Tanaka, K. (2003). Neuronal correlates of goal-based motor selection in the prefrontal cortex. Science, 301, 229–232.CrossRefGoogle Scholar
  29. McGowan, P. O., & Szyf, M. (2010). The epigenetics of social adversity in early life: Implications for mental health outcomes. Neurobiology of Disease, 39, 66–72.CrossRefGoogle Scholar
  30. McGowan, P. O., Sasaki, A., D’Alessio, A. C., Dimov, S., Labonté, B., Szyf, M., Turecki, G., & Meaney, M. J. (2009). Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nature Neuroscience, 12(3), 342–348.CrossRefGoogle Scholar
  31. Mishkin, M., & Appenzeller, T. (1987). The anatomy of memory. Scientific American, 256(6), 80–89.CrossRefGoogle Scholar
  32. Nofzinger, E. A., Mintun, M. A., Wiseman, M. B., Kupfer, D. J., & Moore, R. Y. (1997). Forebrain activation in REM sleep: An FDG PET study. Brain Research, 770, 192–201.CrossRefGoogle Scholar
  33. Northoff, G., & Hayes, D. J. (2011). Is our self nothing but reward? Biological Psychiatry, 69, 1019–1025.CrossRefGoogle Scholar
  34. Northoff, G., Wiebking, C., Feinberg, T., & Panksepp, J. (2011). The ‘resting-state hypothesis’ of major depressive disorder—A translational subcortical–cortical framework for a system disorder. Neuroscience and Biobehavioral Reviews, 35(9), 1929–1945. doi: 10.1016/j.neubiorev.2010.12.007.CrossRefGoogle Scholar
  35. Palombo, S. R. (1973). The associative memory tree. Psychoanalysis and Contemporary Science, 2, 205–219.Google Scholar
  36. Palombo, S. R. (1978). Dreaming and memory: A new information processing model. New York: Basic Books.Google Scholar
  37. Panksepp, J. (1998). Affective neuroscience: The foundations of human and animal emotions. New York: Oxford University Press.Google Scholar
  38. Piaget, J. (1928). Judgment and reasoning in the child. London: Routledge. (Original work published 1924)Google Scholar
  39. Posner, M. I., & DiGirolamo, G. J. (1998). Executive attention: Conflict, target detection, and cognitive control. In R. Parasuraman (Ed.), The attentive brain (pp. 401–423). Cambridge, MA: MIT Press.Google Scholar
  40. Reiser, M. F. (1984). Mind, brain, body: Toward a convergence of psychoanalysis and neurobiology. New York: Basic Books.Google Scholar
  41. Reiser, M. F. (1990). Memory in mind and brain: What dream imagery reveals. New York: Basic Books.Google Scholar
  42. Risch, N., Herrell, R., Lehner, T., Liang, K.-Y., Eaves, L., Hoh, J., Griem, A., Kovacs, M., Ott, J., & Merikangas, K. R. (2009). Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: A meta-analysis. The Journal of the American Medical Association, 301(23), 2462–2471.CrossRefGoogle Scholar
  43. Roelofs, A., van Turennout, M., & Coles, M. G. H. (2006). Anterior cingulate cortex activity can be independent of response conflict in Stroop-like tasks. Proceedings of the National Academy of Sciences, 103, 13884–13889.CrossRefGoogle Scholar
  44. Solms, M. (2000). Dreaming and REM sleep are controlled by different brain mechanisms. Behavioral Brain Sciences, 23(6), 843–850.CrossRefGoogle Scholar
  45. Stuphorn, V., & Schall, J. D. (2006). Executive control of countermanding saccades by the supplementary eye field. Nature Neuroscience, 9, 925–931.CrossRefGoogle Scholar
  46. Winson, J. (1985). Brain and psyche: The biology of the unconscious. New York: Anchor.Google Scholar
  47. Wollheim, R. (1999). On the emotions. New Haven: Yale University Press.Google Scholar

Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Sigmund-Freud-InstitutFrankfurt am MainGermany

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