How Should Patients with Recurrent Disease Be Treated Actually?
It was the unsatisfactory results of conventional-dose chemotherapy at the time of relapse, that led to HDCT being introduced into clinical practice. Even today, the combination of carboplatin and etoposide (CE) remains the mainstay of all salvage regimens with HDCT. The use of HDCT has resulted in long-term remission being achieved even in patients with unfavorable prognoses or multiple relapses. What remains controversial, however, is the role of HDCT as first-line salvage therapy in relapsed patients with highly favorable risk profiles. In order to avoid overtreatment, HDCT should only be administered at specialist centres with the necessary expertise.
KeywordsGerm cell tumor Relapse High-dose chemotherapy Prognosis
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