Subcutaneous Panniculitis-Like T-Cell Lymphoma

  • Amrita Goyal
  • Joi B. Carter
  • Lyn McDivitt DuncanEmail author


Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a cytotoxic T-cell lymphoma with an excellent prognosis. Patients present with recurrent, generally painless, erythematous subcutaneous tumors on the trunk and extremities, often followed by lipoatrophy. Of note, this diagnosis previously encompassed two different diseases: lymphomas composed of alpha/beta-type T cells and lymphomas of gamma/delta T cells [1]. In the most recent WHO-EORTC guidelines, these have now been separated into SPTCL and primary cutaneous gamma/delta T-cell lymphoma (pcGDTCL), respectively [2]. Older studies, which lumped together both the alpha/beta and gamma/delta lymphomas, may report lower 5-year survival rates and poorer prognosis, reflecting the more aggressive course of pcGDTCL. This chapter discusses the clinical presentation, prognosis, and treatment of SPTCL, as well as its histopathology and immunohistochemistry. The chapter closes with a differential diagnosis and a clinical case.


Subcutaneous panniculitis-like T-cell lymphoma SPTCL CD8+ cytotoxic T-cell lymphoma Alpha/beta TCR Hemophagocytic syndrome Primary cutaneous gamma-delta T-cell lymphoma Erythema nodosum Lupus profundus Lupus panniculitis 


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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  • Amrita Goyal
    • 1
  • Joi B. Carter
    • 2
  • Lyn McDivitt Duncan
    • 3
    Email author
  1. 1.Harvard-MIT Division of Health Sciences and TechnologyHarvard Medical SchoolBostonUSA
  2. 2.Department of DermatologyMassachusetts General Hospital, Harvard Medical SchoolBostonUSA
  3. 3.Dermatopathology Service, Department of PathologyMassachusetts General Hospital, Harvard Medical SchoolBostonUSA

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